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Featured Studies

Office of Patient Recruitment

This web page makes it easy to search for featured research studies at the NIH Clinical Center. You can search for specific studies by entering keywords related to your symptoms in the search box or by using the sort and filter options.


To view a full list of all studies conducted at the NIH Clinical Center, visit Search the Studies.

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17 results
Close-up portrait of a woman with a sorrowful expression, illuminated against a dark background, evoking feelings of loneliness and mental distress

A Feasibility Study of Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)

Dr. Regenold and his team at the National Institutes of Health (NIH) are leading a study to explore an investigational new, non-invasive brain stimulation technique to see if it can safely support people experiencing symptoms of depression.

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3D medical illustration depicting human kidneys and blood vessels, rendered in a polygonal, interconnected design

A Study of an Investigational Drug for Focal Segmental Glomerulosclerosis (FSGS)

Dr. Gahl and his team at the National Human Genome Research Institute are seeking volunteers aged 18 and older with primary FSGS to participate in a research study on the effects of an experimental drug, ManNAc, on this disease. The study aims to assess the long-term safety and tolerability of ManNAc and determine whether it can reduce protein in the urine of people with FSGS.

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Close-up of a woman looking out a window, reflecting a sense of loneliness

An Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

Researchers at the National Institute of Mental Health (NIMH) are studying an investigational drug, HNK, to see if it is effective in treating major depression. If you're 18–70 years old and have major depressive disorder (MDD), you may qualify for this 12- to 14-week inpatient research study.

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A doctor consulting a patient

Phase 1 Study with Dose Expansion of the Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants with Mesothelin-Expressing Solid Tumors Including Mesothelioma

Researchers at NCI are developing a new investigational treatment known as TNhYP218 CAR T cells to target and kill tumor cells in people with solid tumors and with those that have high levels of mesothelin (MSLN) including mesothelioma. The study team collects immune cells (T cells); the T cells are genetically modified to target and kill tumor cells to potentially shrink the tumor.

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A doctor examining a patient's throat

An Open-Label Study of Zemaira (Alpha 1-Trypsin Inhibitor) in Subjects with Eosinophilic Esophagitis

Research Study #001854-I to explore the effects of Zemaira® for individuals with eosinophilic esophagitis (EoE). This study aims to understand how people with EoE feel while taking Zemaira® and whether it provides any benefits. By joining this research, you'll have the opportunity to contribute to medical advancements that could improve care for those with EoE. Every patient plays a key role in shaping future treatments and expanding knowledge about this condition. 

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A male patient having his thyroid/neck examined by a doctor

The Role of 68-Gallium-DOTATATE-PET/CT in the Imaging of Metastatic Thyroid Cancer

Did you know your thyroid gland produces hormones that regulate body temperature, heart rate and metabolism? Physicians want to explore a better method to detect thyroid tumors by using a compound called 68Gallium-DOTATATE. This compound may bind to a tumor and make it visible during a PET/CT scan. This information will help guide future research and treatment.

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Evaluation for NCI Surgery Branch Clinical Research Protocols

Evaluation for NCI Surgery Branch Clinical Research Protocols

Doctors at the National Cancer Institute (NCI) are looking for volunteers with metastatic cancers, including breast, ovarian, endometrial, gastrointestinal, genitourinary, hepatobiliary, pancreatic, melanoma, non-small cell lung cancer (NSCLC), and multiple myeloma with solid masses. Potential participants will be evaluated with new immunotherapy treatments utilizing cell transfer immunotherapies in a research trial.

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Role of Genetic Factors in the Development of Lung Disease

Role of Genetic Factors in the Development of Lung Disease

Researchers at the National Institutes of Health (NIH) are studying if low dose CT scans are as effective as regular CT scans to monitor your disease status. Very low-dose scanning uses about 1/30th the amount of radiation as a regular CT scan.
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Role of Genetic Factors in the Development of Lung Disease

Role of Genetic Factors in the Development of Lung Disease

Cystic fibrosis (CF) is a progressive, genetic disease that causes persistent lung infections and over time limits the ability of individuals to breathe. Researchers at the National Institutes of Health (NIH) are studying the infection, disease progression, and abnormal genes responsible for cystic fibrosis to better understand the disease process and its effects on breathing.

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The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment with Beta-3-Adrenergic Receptor Agonists

The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment with Beta-3-Adrenergic Receptor Agonists

Women diagnosed with polycystic ovary syndrome (PCOS) needed for a research study at the National Institutes of Health (NIH). Researchers want to learn more about how a medication may be used to help your body's insulin work better and if this can improve your overall metabolic health.
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