Seeking Adults and Children With MDS or MDS/MPN
Dr. El Jurdi and her team at the National Institutes of Health (NIH) are seeking adults and children aged 12 and older with myelodysplastic syndrome (MDS) or myelodysplastic/myeloproliferative neoplasm (MDS/MPN) for a clinical research study. This clinical research study is evaluating the safety and effectiveness of an investigational drug, pacritinib. Parental consent is required for minors.
A Randomized, Double-Blind, Placebo-Controlled, Flexible Dose Phase 2 Study of Efficacy and Safety of Tirzepatide in Individuals with Alcohol Use Disorder and Metabolic Alcohol-associated Liver Disease
The National Institutes of Health (NIH) is conducting a research study to explore whether an investigational GLP1 medication called Tirzepatide can help people improve liver health. This study focuses on individuals who are overweight and drink alcohol regularly.
A Phase I Study of Autologous T Cells Transduced with Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients with Acute Myeloid Leukemia, Myelodysplastic Syndrome, and other Hematologic Malignancies
Dr. James Kochenderfer and team with the National Cancer Institute at the National Institutes of Health (NIH) are conducting a clinical research study evaluating an investigational immune cell (T-cell) therapy for adults with certain blood cancers that have not responded to standard treatments. Our goal is to see if this approach is safe for people with blood cancers.
Imaging and Biopsy of People with HIV-1 Undergoing Analytic Treatment Interruption
The National Institutes of Health is enrolling adults living with HIV who are on stable antiretroviral therapy (ART) for a clinical research study led by Chuen-Yen Lau, M.D.
A Phase 1 Study to Evaluate the Safety and Tolerability of Escalating Doses of VAS-101 in Subjects with Stable Sickle Cell Disease
NIH researchers are seeking adults aged 18 and older with sickle cell disease for a research study evaluating VAS-101 gel, an investigational product containing curcumin, to determine whether it is safe and well-tolerated.
Advancing Treatment Options for Recurrent Glioblastoma
Adults with recurrent glioblastoma may be eligible for an NIH research study evaluating LMP744, an investigational drug with FDA orphan drug designation for gliomas. The study aims to assess the drug's safety and both its short- and long-term treatment effects.
Prospective Cross-Over Study of the Effects of Meal Macronutrients on Postprandial Lipids
NIH researchers need volunteers with a health condition that affects how their body handles fats. Adults 18+ with conditions that affect how the body handles fats, like obesity, lipodystrophy, nephrotic syndrome, type 2 diabetes, and fatty liver, may be eligible to participate in a research study looking at how different fats in meals affect fat levels in the blood.
Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjögren's Disease Phase IIa Open-Label Clinical Trial and Associated Mechanistic Studies
Dr. Blake Warner and a group of NIH researchers are testing tofacitinib, an investigational oral medication, to help better understand and treat Sjögren's symptoms. Tofacitinib is already approved by the United States Food and Drug Administration (FDA) for other autoimmune conditions and is being used investigationally in this research study.
Observational Study of Dietary Intake and Dietary Behaviors in Adults with Sickle Cell Disease
Are you living with sickle cell disease (SCD)? You may wonder how diet and nutrition affect your overall health and well-being. Researchers at the National Institutes of Health (NIH) are conducting a study to investigate how diet and nutrition impact the physical and mental health of adults with SCD.
Is Your Child Struggling To Sleep Through the Night? It Could Be Sleep Apnea, and NIH Researchers Are Working on New Ways To Help
The NIH Clinical Center is studying an investigational wearable device, not approved by the FDA, that children wear during sleep to measure oxygen levels and collect important information about their health. Your child's participation could help advance pediatric sleep research while receiving a no-cost research evaluation. Compensation provided.