Hormone Replacement Therapy in Adolescents with Premature Ovarian Insufficiency
Are you or someone you know affected by Premature Ovarian Insufficiency (POI)? POI happens when the ovaries stop working properly in young females, causing lower estrogen levels.
A Phase I Study of Autologous T Cells Transduced with Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients with Acute Myeloid Leukemia, Myelodysplastic Syndrome, and other Hematologic Malignancies
Dr. James Kochenderfer and team with the National Cancer Institute at the National Institutes of Health (NIH) are conducting a clinical research study evaluating an investigational immune cell (T-cell) therapy for adults with certain blood cancers that have not responded to standard treatments. Our goal is to see if this approach is safe for people with blood cancers.
Advancing Treatment Options for Recurrent Glioblastoma
Adults with recurrent glioblastoma may be eligible for an NIH research study evaluating LMP744, an investigational drug with FDA orphan drug designation for gliomas. The study aims to assess the drug's safety and both its short- and long-term treatment effects.
Prospective Cross-Over Study of the Effects of Meal Macronutrients on Postprandial Lipids
NIH researchers need volunteers with a health condition that affects how their body handles fats. Adults 18+ with conditions that affect how the body handles fats, like obesity, lipodystrophy, nephrotic syndrome, type 2 diabetes, and fatty liver, may be eligible to participate in a research study looking at how different fats in meals affect fat levels in the blood.
Prospective Cross-Over Study of the Effects of Meal Macronutrients on Postprandial Lipids
Healthy Volunteers Needed for Nutrition & Heart Health Research. Researchers at the National Institutes of Health are studying how meals with different nutrient levels affect fats in the blood, which may play a role in heart disease and other health conditions.
THREAT: Testing Harms Related to Exposure to Allergenic and Epithelial Toxins
Dr. Komarow and his team at the National Institutes of Health (NIH) are conducting a clinical research study to better understand how everyday environmental exposures may affect allergic and inflammatory responses in healthy adults. With allergic and inflammatory conditions increasing over time, this study aims to explore how common substances in air, food, and personal care products influence human health.
Is Your Child Struggling To Sleep Through the Night? It Could Be Sleep Apnea, and NIH Researchers Are Working on New Ways To Help
The NIH Clinical Center is studying an investigational wearable device, not approved by the FDA, that children wear during sleep to measure oxygen levels and collect important information about their health. Your child's participation could help advance pediatric sleep research while receiving a no-cost research evaluation. Compensation provided.
A Feasibility Study of Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)
Dr. Regenold and his team at the National Institutes of Health (NIH) are leading a study to explore an investigational new, non-invasive brain stimulation technique to see if it can safely support people experiencing symptoms of depression.
A Study of an Investigational Drug for Focal Segmental Glomerulosclerosis (FSGS)
Dr. Gahl and his team at the National Human Genome Research Institute are seeking volunteers aged 18 and older with primary FSGS to participate in a research study on the effects of an experimental drug, ManNAc, on this disease. The study aims to assess the long-term safety and tolerability of ManNAc and determine whether it can reduce protein in the urine of people with FSGS.
An Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
Researchers at the National Institute of Mental Health (NIMH) are studying an investigational drug, HNK, to see if it is effective in treating major depression. If you're 18–70 years old and have major depressive disorder (MDD), you may qualify for this 12- to 14-week inpatient research study.