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Featured Studies

This web page makes it easy to search for featured research studies at the NIH Clinical Center. You can search for specific studies by entering keywords related to your symptoms in the search box or by using the sort and filter options.


To view a full list of all studies conducted at the NIH Clinical Center, visit Search the Studies.

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48 results
A father checking his child's forehead temperature for a fever

Evaluating the Genetics and Immunology of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome and Other Tonsil Disorders

Do you or your child experience recurring fever with mouth sores (canker sores), sore throat, or swollen neck glands? These could be symptoms of PFAPA, the most common periodic fever syndrome in children.

Dr. Manthiram and her team at the National Institute of Allergy and Infectious Diseases (NIAID) seek volunteers who are one month and older (parental consent required for minors) to participate in a research study to better understand PFAPA. Compensation provided. Participants can join from home anywhere in the USA or internationally.

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Woman having her thyroid/neck imaged

The Use of 124-I-PET/CT Whole Body and Lesional Dosimetry in Differentiated Thyroid Cancer

Researchers at @NIDDKgov are studying new methods in treating thyroid cancer that has spread outside the thyroid – to the lymph nodes, lungs, or bones We are now enrolling patients age 18 years and older with thyroid cancer that spread outside the thyroid. All study tests and procedures are provided at no cost. 

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CAR-T Cell Treatment for Patients with Glypican-3 (GPC3) Positive HCC (A Type of Liver Cancer)

CAR-T Cell Treatment for Patients with Glypican-3 (GPC3) Positive HCC (A Type of Liver Cancer)

Investigators at the National Cancer Institute (NCI) are enrolling patients with advanced hepatocellular cancers (HCC), in a clinical trial using engineered immune cells, also known as chimeric antigen receptor T-cells or CAR-T cells. In this study, your immune T-cells are collected and modified to target Glypican-3 (GPC3), a protein marker found on the surface of HCC tumors. Researchers hope the altered cells will help identify and fight the cancer cells.
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Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies

Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies

NIH study # 000479-H investigates the impact of treatments intended to cure sickle cell disease (SCD) on organ function. If you or your loved one has SCD, we invite you to call us to learn more about this observational study.
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Studies on Tumors of the Thyroid

Studies on Tumors of the Thyroid

Doctors at the National Institutes of Health (NIH) are conducting a research study for thyroid cancer. Researchers are using a novel imaging technique called 68Gallium DOTATATE PET/CT, which has been proven safe and effective in patients with other tumors - neuroendocrine tumors.
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Viral Load in Blood and Lymph Tissues of HIV-Infected Individuals

Viral Load in Blood and Lymph Tissues of HIV-Infected Individuals

Doctors at the National Institutes of Health (NIH) are conducting a research study to learn more about the immune system and its response to HIV infection in lymph nodes. All study-related tests and procedures are provided at no cost to the study participant.
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Treatment of Patients With Cysticercosis With Praziquantel or Albendazole

Treatment of Patients With Cysticercosis With Praziquantel or Albendazole

Are you from Mexico, Central or South America, or India with hydrocephalus, seizures, or an inflammatory condition of the central nervous system without a diagnosis? The National Institutes of Health (NIH) is studying people with cysticercosis and those likely to have cysticercosis. All study related tests and procedures are provided at no cost to you. Travel to and from NIH may be reimbursed.

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Investigation of the Natural Progression of Clonal Hematopoiesis of Indeterminate Potential and Clonal Cytopenia of Undetermined Significance

Investigation of the Natural Progression of Clonal Hematopoiesis of Indeterminate Potential and Clonal Cytopenia of Undetermined Significance

Doctors at the National Institutes of Health (NIH) are conducting a study on patients with Clonal Cytopenia of Uncertain Significance (CCUS). Patients with CCUS have low blood counts and a normal bone marrow exam but more advanced genetic testing shows the presence of a genetic mutation that is likely causing the low counts. The study will look at CCUS and try to determine its relationship to blood cancers and heart disease. The study will also try to discover other new organs or diseases it may be linked with.
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A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue

A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue

The National Institute of Nursing Research (NINR), at the National Institutes of Health (NIH) is seeking people who are cancer survivors or have a chronic illness such as myalgic encephalomyelitis (ME), chronic fatigue syndrome (CFS), Sjogren's disease, or Lupus to participate in a research study on fatigue. Fatigue is a common side effect of various illnesses. Researchers want to test if a one-time dose of the medication Ketamine or a similar drug can reduce fatigue. This is not a treatment study for fatigue, cancer, ME, CFS, Sjogren's disease, or Lupus. Study procedures and medications are provided at no cost. Travel costs for study visits will be reimbursed in accordance with NIH guidelines.
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Phase II Trial Evaluating Nivolumab in Patients with IDH-Mutant Gliomas with and without Hypermutator Phenotype

Phase II Trial Evaluating Nivolumab in Patients with IDH-Mutant Gliomas with and without Hypermutator Phenotype

National Cancer Institute (NCI) researchers are conducting a study of patients with IDH-mutated gliomas. This study will test whether stimulating the immune system using the drug nivolumab can shrink recurrent IDH-mutant gliomas with and without hypermutator phenotype or increase the time it takes for them to grow or spread.

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