A Phase 1 Study to Evaluate the Safety and Tolerability of Escalating Doses of VAS-101 in Subjects with Stable Sickle Cell Disease
NIH researchers are seeking adults aged 18 and older with sickle cell disease for a research study evaluating VAS-101 gel, an investigational product containing curcumin, to determine whether it is safe and well-tolerated.
Advancing Treatment Options for Recurrent Glioblastoma
Adults with recurrent glioblastoma may be eligible for an NIH research study evaluating LMP744, an investigational drug with FDA orphan drug designation for gliomas. The study aims to assess the drug's safety and both its short- and long-term treatment effects.
Prospective Cross-Over Study of the Effects of Meal Macronutrients on Postprandial Lipids
NIH researchers need volunteers with a health condition that affects how their body handles fats. Adults 18+ with conditions that affect how the body handles fats, like obesity, lipodystrophy, nephrotic syndrome, type 2 diabetes, and fatty liver, may be eligible to participate in a research study looking at how different fats in meals affect fat levels in the blood.
Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjögren's Disease Phase IIa Open-Label Clinical Trial and Associated Mechanistic Studies
Dr. Blake Warner and a group of NIH researchers are testing tofacitinib, an investigational oral medication, to help better understand and treat Sjögren's symptoms. Tofacitinib is already approved by the United States Food and Drug Administration (FDA) for other autoimmune conditions and is being used investigationally in this research study.
Observational Study of Dietary Intake and Dietary Behaviors in Adults with Sickle Cell Disease
Are you living with sickle cell disease (SCD)? You may wonder how diet and nutrition affect your overall health and well-being. Researchers at the National Institutes of Health (NIH) are conducting a study to investigate how diet and nutrition impact the physical and mental health of adults with SCD.
A Feasibility Study of Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)
Dr. Regenold and his team at the National Institutes of Health (NIH) are leading a study to explore an investigational new, non-invasive brain stimulation technique to see if it can safely support people experiencing symptoms of depression.
A Study of an Investigational Drug for Focal Segmental Glomerulosclerosis (FSGS)
Dr. Gahl and his team at the National Human Genome Research Institute are seeking volunteers aged 18 and older with primary FSGS to participate in a research study on the effects of an experimental drug, ManNAc, on this disease. The study aims to assess the long-term safety and tolerability of ManNAc and determine whether it can reduce protein in the urine of people with FSGS.
An Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
Researchers at the National Institute of Mental Health (NIMH) are studying an investigational drug, HNK, to see if it is effective in treating major depression. If you're 18–70 years old and have major depressive disorder (MDD), you may qualify for this 12- to 14-week inpatient research study.
A Feasibility Multicenter Phase I Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing
Researchers are enrolling people with locally advanced or metastatic cancer who are prescribed atezolizumab (alone or with other approved treatments). The study will monitor blood levels to adjust infusion schedules, aiming to see if lower or less frequent doses can be given without reducing effectiveness, over a period of up to 2 years.
Be Part of a Study That Could Change How We Detect Helicobacter pylori
This study explores whether the Esophageal String Test (EST), a simple, less invasive procedure can accurately detect H. pylori and antibiotic resistance, compared to traditional testing that uses endoscopic biopsies.