Skip to main content

Patient Recruitment

The Use of 124-I-PET/CT Whole Body and Lesional Dosimetry in Differentiated Thyroid Cancer

Thyroid Cancer Research Study

medical illustration of a human throat highlighting thyroid cancer cells

Doctors at the National Institutes of Health (NIH) seek patients with thyroid cancer that spread outside the thyroid – to the lymph nodes, lungs or bones. The standard treatment in such situation is therapy with radioactive iodine (RAI). In this study, doctors will assess a new imaging tool - 124I PET/CT, which enables evaluation of how much iodine goes into the tumor. The study goal is to compare how much iodine goes into cancer cells after two different methods of stimulation of RAI uptake:

  • A shot of a recombinant human thyroid stimulating hormone (TSH) called Thyrogen
  • Stimulation with your own TSH, which is achieved by stopping thyroid hormone medication for 4 weeks.

The imaging will be followed by therapy with RAI dose individualized to each patient, based on the tumor uptake measured by 124I PET/CT.

Who Can Participate?

  • 18 or older who have thyroid cancer that has spread outside the thyroid

Participation Includes:

  • Two admissions to the NIH Clinical Center, about 4 weeks apart
  • A low iodine diet for two weeks before each admission, to make cancer cells "hungry" for iodine
  • Therapy with radioactive iodine, if indicated, and evaluation of response to treatment at least yearly for the next 5 years

Study-related procedures and medications are provided at no cost.

Location: The NIH Clinical Center, America's Research Hospital is located in Bethesda, Maryland, on the Metro red line (Medical Center ).

For more information, contact:
NIH Clinical Center Office of Patient Recruitment
1-800-411-1222 (refer to study # 19-DK-0050)
TTY users call via MD Relay 7-1-1
Se habla español

Or go online:

Department of Health and Human Services
National Institutes of Health Clinical Center (CC)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NOTE: PDF documents require the free Adobe Reader.

This page last updated on 10/22/2021

You are now leaving the NIH Clinical Center website.

This external link is provided for your convenience to offer additional information. The NIH Clinical Center is not responsible for the availability, content or accuracy of this external site.

The NIH Clinical Center does not endorse, authorize or guarantee the sponsors, information, products or services described or offered at this external site. You will be subject to the destination site’s privacy policy if you follow this link.

More information about the NIH Clinical Center Privacy and Disclaimer policy is available at