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Patient Recruitment

Do You Have Pulmonary Arterial Hypertension?

Join NIH Research

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Researchers at the National Institutes of Health (NIH) Clinical Center are testing if spironolactone can be used to treat PAH. Spironolactone is a medication that can help with fluid retention, however it may also be beneficial to adults with PAH by controlling inflammation and improving blood vessel function in the lungs.

If you have been diagnosed with PAH talk to your doctor about joining this study.

Participation includes:

  • A medical history, physical examination, blood tests, lung function tests, exercise tests, imaging scans and quality of life questionnaires.
  • 2 to 3 visits to the NIH Clinical Center over a 6-month period.
  • Being assigned to take spironolactone or placebo (inactive pill) for 24 weeks. Neither you nor the study team will know if you are receiving the medication or placebo.

You may be eligible if you:

  • Are at least 18 years old.
  • Have been diagnosed with PAH.
  • Are not pregnant or breastfeeding.

All study-related tests and medication are provided at no cost. Travel within the U.S. and accommodations may be reimbursed by the study.

Location: The NIH Clinical Center, America's Research Hospital is located in Bethesda, Maryland in the Washington, DC metro area.

For more information:
NIH Clinical Center Office of Patient Recruitment
1-800-411-1222 (refer to study #12-CC-0211)
TTY for the deaf or hard of hearing: 1-866-411-1010
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Or go online:

Department of Health and Human Services
National Institutes of Health Clinical Center (CC)

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This page last updated on 10/22/2021

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