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Astute Clinician Lecture

An NIH Director's Wednesday Afternoon Lecture Series Event

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"Gaucher Disease: How a Rare Disease Provides a Window into Common Neurodegenerative Disorders"

Speaker: Ellen Sidransky, MD
Branch Chief, Medical Genetics Branch, National Human Genome Research Institute, NIH

Wednesday, November 4, 2020 – Remote Only
3:00-4:00 p.m.

Ellen Sidransky, MD will present the 23rd annual Astute Clinician Lecture as part of the Wednesday Afternoon Lecture Series on November 4, 2020.

Dr. Ellen Sidransky will present the Annual Astute Clinician Lecture on November 4, 2020. Her lecture, "Gaucher Disease: How a Rare Disease Provides a Window into Common Neurodegenerative Disorders" can be viewed live via videocast at

Individuals with disabilities who need reasonable accommodation to participate in these events should contact the WALS Office,, or the Federal Relay, 800-877-8339.

For information, email

Visit the Wednesday Afternoon Lecture Series web site at

Download the Flyer

Past Astute Clinician Lectures

Flyer for the 23rd Astute Clinician Lecture on Wednesday, November 4, 2020 (Remote Only) from 3-4pm - Gaucher Disease: How a Rare Disease Provides a Window into Common Neurodegenerative Disorders presented by Ellen Sidransky, MD

The Astute Clinician Lecture Series

The Astute Clinician Lecture was established through a gift from the late Dr. Robert W. Miller and his wife, Haruko. It honors a US clinician-scientist who has observed an unusual clinical occurrence, and by investigating it, has opened an important new avenue of research.

Continuing Medical Education (CME) activities offered by NIH are jointly sponsored in partnership with The Johns Hopkins University School of Medicine Office of CME.

The WALS is intended for advanced students and practitioners in biomedical fields, healthcare professionals, and doctoral-level scientists who seek to update and broaden their understanding of contemporary biomedical research and the environment in which it is conducted.

Activity Description: The Wednesday Afternoon Lecture Series provides a mechanism to stay abreast of state-of-the-art biomedical and health research.

Intended Audience: All physicians, allied health professionals and non-clinical scientists, as well as the general public, are invited to attend the Wednesday Afternoon Lecture Series.

Objectives: After attending the activity, participants will be able to: (1) define options, alternatives, and new practices that will guide the conduct of research; (2) evaluate practical information presented about laboratory, clinical, and population-based research principles based on state-of-the-art scientific discovery and achievements; and (3) analyze information and opportunities to increase and improve collaboration among investigators and move scientific frontiers forward, especially to bridge areas of laboratory, translational, and clinical research.

Accreditation Statement: This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Johns Hopkins University School of Medicine and the National Institutes of Health. The Johns Hopkins University School of Medicine is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation Statement: The Johns Hopkins University School of Medicine designates this live activity for a maximum of 39 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Policy on Speaker and Provider Disclosure: It is the policy of The Johns Hopkins University School of Medicine that the speaker and provider disclose real or apparent conflicts of interest relating to the topics of this educational activity, and also disclose discussions of unlabeled/unapproved uses of drugs or devices during their presentation(s). The Johns Hopkins University School of Medicine OCME has established policies in place that will identify and resolve all conflicts of interest prior to this educational activity. Detailed disclosure will be made in the activity handout materials.

Past Astute Clinician Lectures

"We Are What We Eat: Nutrition, Genes, Cognition and Deep Learning in Age-related Macular Degeneration"
December 11, 2019 - Dr. Emily Chew

"What Makes America Great"
November 7, 2018 - Dr. William A. Gahl

"Sugar and the Beating Heart: The Conundrum of Heart Failure in Diabetes"
February 7, 2018 - Dr. E. Dale Abel

"Perspective on Autoimmunity: A View from the ANCA Vasculitis Looking Glass"
November 2, 2016 - Dr. Ronald J. Falk

"Relief from Severe Depression and Suicidal Ideation Within Hours: from Synapses to Symptoms"
November 4, 2015 - Dr. Carlos A. Zarate

"Past and Future Therapy of Hepatitis C"
November 12, 2014 - Dr. Jay H. Hoofnagle

"The Genetic Basis of Kidney Cancer: Targeting the Metabolic Basis of Disease"
November 20, 2013 - Dr. W. Marston Linehan

"The Value of Clinical Clues in Solving Neurogenetic Riddles"
November 7, 2012 - Dr. Huda Y. Zoghbi

"Developing Treatment for Hereditary Neuromuscular Disease"
November 2, 2011 - Dr. Kenneth H. Fischbeck

"Genes versus Fast Food: Eat, Drink and Be Wary"
November 17, 2010 - Dr. Helen Hobbs

"Fevers, Genes, and Histories: Adventures in the Genomics of Inflammation"
November 18, 2009 - Dr. Daniel Kastner

"Marfan Syndrome and Releated Disorders: from Molecules to Medicines"
January 14, 2009 - Dr. Harry Dietz

"From the Rivers of Babylon to the Coronary Blood Stream"
November 7, 2007 - Dr. Barry S. Coller

"Listening to Patients: Lessons Learned in the Development of Cancer Immunotherapy"
November 1, 2006 - Dr. Steven A. Rosenberg

"Inflammation, CRP and Cardiovascular Risk: Is It Time to Change the Framingham Risk Score?"
November 2, 2005 - Dr. Paul M. Ridker

"Insulin Resistance and Metabolic Syndromes: Different Names, Different Concepts, Different Goals"
November 3, 2004 - Dr. Gerald M. Reaven

"Cochlear Implants, Past, Present, and Future"
November 5, 2003 - Dr. Richard T. Miyamoto

"AIDS: A Window on Infectious Diseases"
November 06, 2002 - Dr. Henry Masur

"STI571: A Tyrosine Kinase Inhibitor for the Treatment of Chronic Myelogenous Leukemia (CML) Validating the Promise of Molecularly Targeted Therapy"
November 07, 2001 - Dr. Brian Druker

"The Patients Who Taught Me and Led to My Discoveries in Congenital Adrenal Hyperplasia"
December 13, 2000 - Dr. Maria I. New

"The Elucidation of Lyme Arthritis"
November 3, 1999 - Dr. Allen C. Steere

"The Link Between Teratogenesis and Carcinogenesis: Lessons from the Wilms Tumor Model"
October 15, 1998 - Dr. J. Bruce Beckwith

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This page last updated on 10/27/2020

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