Featured Studies

Researchers at the National Institutes of Health (NIH) seek participants age five and older with childhood-onset brain injury (e.g.,cerebral palsy) to join a research study. Near-infrared spectroscopy (NIRS) and/or electroencephalography (EEG) may be used to study brain activity. Learning how the brain controls muscles may help design treatments to help patients with brain injury to move better.

Researchers at the National Institutes of Health (NIH) Clinical Center are testing if spironolactone can be used to treat PAH. Spironolactone is a medication that can help with fluid retention, however it may also be beneficial to adults with PAH by controlling inflammation and improving blood vessel function in the lungs.

Researchers want to see if they can measure the amount of anti-cancer drug, Abemaciclib in a brain tumor and brain fluid after a patient has taken this drug for a few days. These findings can help explain how much drug gets into the brain and how drugs work to shrink high grade gliomas to improve outcomes for these patients.

Myelodysplastic syndromes (MDS) are disorders caused by abnormal blood cell production, potentially leading to low cell counts and increased susceptibility to clotting and infections. Past research suggests that inflammation may trigger these abnormalities, and this study seeks to further understand and improve treatment strategies for MDS by investigating the role of inflammation in bone marrow cell development.

Researchers from the National Cancer Institute at the NIH Clinical Center are currently looking for patients who have HER2-expressing endometrial cancer. The purpose of the study is to test two investigational study drugs, a vaccine that targets HER2 (AdHER2DC) and a drug that is expected to improve immune cell function (N-803). These study drugs will be used with pembrolizumab and lenvatinib which are FDA approved to treat endometrial cancer.

The risk of heart disease among African Americans is still common despite a greater understanding of the disease and better approaches to managing it. Healthy cooking and eating patterns can help reduce the risk of heart disease. But things like access to grocery stores and knowledge of good nutrition can affect these healthy patterns. Researchers at The National Institutes of Health want to see if community-based programs can help.