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Department of Laboratory Medicine

David B. Sacks, MB ChB, FACP, FRCPath, Curriculum Vitae

Dr. David B. Sacks is the Senior Investigator.

Work Address

NIH Clinical Center
Department of Laboratory Medicine
Bldg 10, Rm 2C306
10 Center Drive
Bethesda, MD 20892
Phone: 301-496-3386
Fax: 301-402-1885
Email: sacksdb@mail.nih.gov

Selected Bibliography

Research Investigations

  • Hedman AC, Li Z, Gorissse L, Parvathaneni S, Morgan CJ, Sacks DB. IQGAP1 binds AMPK and is required for maximum AMPK activation. J Biol Chem 2021, in the press.
  • Dalal PJ, Sullivan DP, Weber E, Sacks DB, Gunzer M, Grumbach I, Brown JH, Muller WA. Spatiotemporal restriction of calcium signaling in endothelial cells during leukocyte transmigration. J Exp Med 2021; 218(1):e20192378.
  • Hedman AC, McNulty DE, Li Z, Gorisse L, Annan RS, Sacks DB. Tyrosine phosphorylation of the scaffold protein IQGAP1 in the MET pathway alters function. J Biol Chem 2020; 295:18105-18121.
  • Wang H, Ramshekar A, Kunz E, Sacks DB, Hartnett ME. IQGAP1 causes choroidal neovascularization by sustaining VEGFR2-mediated Rac1 activation. Angiogenesis 2020; 23:685-698.
  • Sayedyahossein S, Hedman AC, Sacks DB. Insulin supresses transcriptional activity of yes-associated protein in insulin target cells. Mol Biol Cell 2020; 31:131-141.
  • Gorisse L, Li Z, Wagner CD, Worthylake DK, Zappacosta F, Hedman AC, Annan RS, Sacks DB. Ubiquitination of the scaffold protein IQGAP1 diminishes its interaction with and activation of the Rho GTPase CDC42. J Biol Chem 2020; 295:4822-4835.
  • Arora PD, Nakajima K, Nanda A, Plaha A, Wilde A, Sacks DB, McCulloch CA. Flightless anchors IQGAP1 and R-ras to mediate cell extension formation and matrix remodeling. Mol Biol Cell 2020; 31:1595-1610
  • Morgan CJ, Hedman AC, Li Z, Sacks DB. Endogenous IQGAP1 and IQGAP3 do not functionally interact with Ras. Sci Rep. 2019 Jul 30;9(1):11057. doi: 10.1038/s41598-019-46677-9.
  • Sullivan DP, Dalal PJ, Jaulin F, Sacks DB, Kreitzer G, Muller WA. Endothelial IQGAP1 regulates leukocyte transmigration by directing the LRBC to the site of diapedesis. J Exp Med 2019; 216:2582-2601.
  • Zhang M, Li Z, Jang H, Hedman AC, Sacks DB, Nussinov R. Ca2+-dependent switch of calmodulin interaction mode with tandem IQ motifs in the scaffolding protein IQGAP1. Biochemistry 2019; 58:4903-4911.
  • Ozdemir ES, Jang H, Gursoy A, Keskin O, Li Z, Sacks DB, Nussinov R. Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2. J Biol Chem 2018; 293:3685-3699.
    [Selected as the representative ‘Computational biology’ article for the 2018 retrospective collection “The year in JBC: 2018.”]
  • Alves G, Wang G, Ogurtsov AY, Drake SK, Gucek M, Suffredini AF, Sacks DB, Yu YK. Rapid classification and identification of multiple microorganism with accurate statistical significance via high-resolution tandem mass spectrometry. J Am Soc Mass Spectrom 2018; 29:1721-1737.
  • Zhang M, Li Z, Wang G, Jang H, Sacks DB, Zhang J, Gaponenko V, Nussinov R. Calmodulin (CaM) activates PI3K⍺ by targeting the “soft” CaM-binding motifs in both the nSH2 and cSH2 domains of p85⍺. J Phys Chem B 2018; 122:11137-11146.
  • Gorisse L, Li Z, Hedman AC, Sacks DB. IQGAP1 binds the Axl receptor kinase and inhibits its signaling. Biochem J 2018; 475:3073-3086.
  • Chawla B, Hedman AC, Sayedyahossein S, Erdemir HH, Li Z, Sacks DB. Absence of IQGAP1 protein leads to insulin resistance. J Biol Chem 2017; 292:3273-3289.
  • Li Z, Zhang Y, Hedman AC, Ames JB, Sacks DB. Calmodulin lobes facilitate dimerization and activation of estrogen receptor-. J Biol Chem 2017; 292:4614-4622.
  • Li Z, Zhang Y, Hedman AC, Ames JB, Sacks DB. Calmodulin lobes facilitate dimerization and activation of estrogen receptor-α. J Biol Chem 2017; 292:4614-4622.
  • Chawla B, Hedman AC, Sayedyahossein S, Erdemir HH, Li Z, Sacks DB. Absence of IQGAP1 protein leads to insulin resistance. J Biol Chem 2017; 292:3273-3289.
  • Choi S, Hedman A, Sayedyahossein S, Thapa S, Sacks DB, Anderson R. Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases. Nature Cell Biol 2016; 18:1324-1335.
  • LeCour L, Boyapati VK, Liu J, Li Z, Sacks DB, Worthylake DK. The structural basis for Cdc42-induced dimerization of IQGAPs. Structure 2016; 24:1499-1508.
  • Bessede E, Molina S, Amador LA, Dubus P, Staedel C, Chambonnier L, Buissoniere A, Sifre E, Giese A, Benejat L, Rousseau B, Costet P, Sacks DB, Megraud F, Varon C. Deletion of IQGAP1 promotes Helicobacter pylori-induced gastric dysplasia in mice and acquisition of cancer stem cell properties in vitro. Oncotarget 2016; 7:80688-80699.
  • Sayedyahossein S, Li Z, Hedman AC, Morgan CJ, Sacks DB. IQGAP1 binds to Yes-associated protein (YAP) and modulates its transcriptional activity. J Biol Chem 2016; 291:19261-19273.
  • Tian Y, Tian X, Gawlak G, Sarich N, Sacks DB, Birukova AA, Birukov KG. Role of IQGAP1 in endothelial barrier enhancement caused by OxPAPC. Am J Physiol Lung Cell Mol Physiol 2016; 311:L800-L809.
  • Choi S, Hedman A, Sayedyahossein S, Thapa S, Sacks DB, Anderson R. Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases. Nature Cell Biol 2016; 18:1324-1335.
    [Highlighted in News and Views]
  • LeCour L, Boyapati VK, Liu J, Li Z, Sacks DB, Worthylake DK. The structural basis for Cdc42-induced dimerization of IQGAPs. Structure 2016; 24:1499-1508.
  • Sayedyahossein S, Li Z, Hedman AC, Morgan CJ, Sacks DB. IQGAP1 binds to Yes-associated protein (YAP) and modulates its transcriptional activity. J Biol Chem 2016; 291:19261-19273.
  • Bessede E, Molina S, Amador LA, Dubus P, Staedel C, Chambonnier L, Buissoniere A, Sifre E, Giese A, Benejat L, Rousseau B, Costet P, Sacks DB, Megraud F, Varon C. Deletion of IQGAP1 promotes Helicobacter pylori-induced gastric dysplasia in mice and acquisition of cancer stem cell properties in vitro. Oncotarget 2016; 7:80688-80699.
  • Lu R, Herrera BB, Eshleman H, Fu Y, Bloom A, Li Z, Sacks DB, Goldberg MB. Shigella effector OspB activates mTORC1 in a manner that depends on IQGAP1 and promotes cell proliferation. PLoS Pathog 2015; 11(10): e1005200. doi: 10.1371/journal.ppat.1005200
  • Tian Y, Gawlak G, Shah AS, Higginbotham K. Tian X, Kawasaki Y, Akiyama T, Sacks DB, Birukova AA. HGF-induced Asef-IQGAP1complex controls cytoskeletal remodeling and endothelial barrier. J Biol Chem 2015; 290:4097-4109.
  • Tanos BE, Perez Bay AE, Salvarezza S, Vivanco I, Mellinghoff I, Osman M, Sacks DB, Rodriguez-Boulan E. IQGAP1 controls tight junction formation through differential regulation of claudin recruitment. J Cell Sci 2015; 128:853-862. [Highlighted on cover and “In This Issue”]
  • Erdemir HH, Li Z, Sacks DB. IQGAP1 binds to estrogen receptor-α and modulates its function. J Biol Chem 2014; 289:9100-9112.
  • Tian Y, Tian X, Gawlak G, O'Donnell J, Sacks DB, Birukova AA. IQGAP1 regulates endothelial barrier function via EB1-cortactin cross talk. Mol Cell Biol 2014; 34:3456-3558.
  • Fram S, King H, Sacks DB, Wells CM. A PAK6:IQGAP1 complex promotes disassembly of cell:cell adhesions. Cell Mol Life Sci 2014; 71:2759-2773.
  • Witze ES, Houel S, Schwartz MP, Morphew MK, Reaid L, Sacks DB, Anseth KS, Ahn NG. Wnt5a directs polarized calcium gradients by recruiting cortical endoplasmic reticulum to the cell trailing edge. Dev Cell 2013; 26:645-657.
  • Choi S, Thapa N, Hedman AC, Li Z, Sacks DB, Anderson RA. IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration. EMBO J 2013; 32:2617-2630.
  • Cheung KL, Lee JH, Shu L. Kim JH, Sacks DB, Kong AN. The Ras GTPase-activating-like protein IQGAP1 mediates Nrf2 protein activation via the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)-ERK pathway. J Biol Chem 2013; 288:22378-22386.
  • Kim JH, Xu EY, Sacks DB, Lee J, Shu L, B Xia B, Kong AN. Identification and functional studies of a new Nrf2 partner IQGAP1: A critical role in the stability and transactivation of Nrf2. Antioxid Redox Signal 2013; 19:89-101.
  • Lee GS, Subramanian N, Kim A, Aksentijevich I, Goldbach-Mansky R, Sacks DB, Germain RN, Kastner DL, Chae JJ. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 2012, 492:123-127.
  • Zhang Y, Li Z, Sacks DB, Ames JB. Structural basis for Ca2+-induced activation and dimerization of estrogen receptor α by calmodulin. J Biol Chem 2012; 287:9336-9344. [Journal of Biological Chemistry Paper of the Week] [Recommended by the Faculty of 1000]
  • Logue JS, Whiting JL, Tunquist B, Sacks DB, Langeberg LK, Wordeman L, Scott JD. AKAP220 protein organizes signaling elements that impact cell migration. J Biol Chem 2011; 286:39269-39281.
  • Kim H, White CD, Li Z, Sacks DB. Salmonella enterica serotype Typhimurium usurps the scaffold protein IQGAP1 to manipulate Rac1 and MAPK signalling. Biochem J 2011; 440:309-318.
  • White CD, Li Z, Dillon DA, Sacks DB. IQGAP1 binds human epidermal growth factor receptor 2 (HER2) and modulates trastuzumab resistance. J Biol Chem 2011; 286:29734-29747. [Recommended by the Faculty of 1000]
  • Sharma S, Findlay GM, Bandukwala HS, Oberdoerffer S, Baust B, Li Z, Schmidt V, Hogan PG, Sacks DB, Rao A. Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc Natl Acad Sci USA 2011; 108:11381-11386.
  • McNulty DE, Li Z, White CD, Sacks DB, Annan RS. MAP kinase scaffold IQGAP1 binds the EGF receptor and modulates its activation. J Biol Chem 2011; 286:15010-15021.
  • McLaughlin LM, Govoni G, Gerke C, Gopinath S, Peng K, Laidlaw G, Chien Y-H, Jeong H-W, Li Z, Brown MD, Sacks DB, Monack D. The Salmonella effector SseI mediates long-term systemic systemic infection by modulating host cell migration. PLOS Pathog 2009; 5 (11):e1000671.
  • Brown MD, Bry L, Li Z, Sacks DB. Actin pedestal formation by EPEC is regulated by IQGAP1, calcium and calmodulin. J Biol Chem 2008; 283: 35212-35222.
  • Ren JG, Li Z, Sacks DB. IQGAP1 integrates Ca2+/calmodulin and B-Raf signaling. J Biol Chem 2008; 283:22972-22982.
  • Owen D, Campbell LJ, Littlefield K, Evetts KA, Li Z, Sacks DB, Lowe PN, Mott HR. The IQGAP1-Rac1 and IQGAP1-Cdc42 interactions: interfaces differ between the complexes. J Biol Chem 2008; 283:1692-1704.
  • Jadeski L, Mataraza JM, Jeong HW, Li Z, Sacks DB. IQGAP1 stimulates proliferation and enhances tumourigenesis of human breast epithelial cells. J Biol Chem 2008; 283:1008-1017.\
  • Brown MD, Bry L, Li Z, Sacks DB. IQGAP1 regulates Salmonella invasion through interactions with actin, Rac1 and Cdc42. J Biol Chem 2007; 282:30265-30272.
  • Jeong HW, Li Z, Brown MD, Sacks DB. IQGAP1 binds Rap1 and modulates its activity. J Biol Chem 2007; 282:20752-20762.
  • Ren JG, Li Z, Sacks DB. IQGAP1 modulates activation of B-Raf. Proc Natl Acad Sci USA 2007; 104:10465-10469.
  • Li L, Li Z, Howley PM, Sacks DB. E6AP and calmodulin reciprocally regulate estrogen receptor stability. J Biol Chem 2006; 281:1978-1985.
  • Roy M, Li Z, Sacks DB. IQGAP1 is a scaffold for mitogen-activated protein kinase signaling. Mol Cell Biol 2005; 25:7940-7952.
  • Ren JG, Li Z, Crimmins DL, Sacks DB. Self association of IQGAP1: Characterization and functional sequelae. J Biol Chem 2005; 280:34548-34557.
  • Li Z, McNulty DE, Marler KJM, Lim L, Hall C, Annan RS, Sacks DB. IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner. J Biol Chem 2005; 280:13871-13878.
  • Li L, Li Z, Sacks DB. The transcriptional activity of estrogen receptor-α is dependent on Ca2+/calmodulin. J Biol Chem 2005; 280:13097-13104.
  • Roy M, Li Z, Sacks DB. IQGAP1 binds ERK2 and modulates its activity. J Biol Chem 2004; 279:17329-17337.
  • Mataraza JM, Briggs MW, Li Z, Entwistle A, Ridley AJ, Sacks DB. IQGAP1 promotes cell motility and invasion. J Biol Chem 2003; 278:41237-41245.
  • Li Z, Sacks DB. Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1. J Biol Chem 2003; 278:4347-4352.
  • Li L, Li Z, Sacks DB. Calmodulin regulates the transcriptional activity of estrogen receptors: selective inhibition of calmodulin function in subcellular compartments. J Biol Chem 2003; 278:1195-1200.
  • Sacks DB, Bruns DE, Goldstein DE, Maclaren NK, McDonald JM, Parrott M. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clin Chem 2002; 48:436-472. [Published concurrently in Diabetes Care 2002; 25:750-786.]
  • Swart-Mataraza JM, Li Z, Sacks DB. IQGAP1 is a component of Cdc42 signaling to the cytoskeleton. J Biol Chem 2002; 277:24753-24763.
  • Briggs MW, Li Z, Sacks DB. IQGAP1-mediated stimulation of transcriptional co-activation by β- catenin is modulated by calmodulin. J Biol Chem 2002; 277:7453-7465.
  • Sokol SY, Li Z, Sacks DB. The effect of IQGAP1 on Xenopus embryonic ectoderm requires Cdc42. J Biol Chem. 2001;276:48425-30.
  • Li Z, Joyal JL, Sacks DB. Calmodulin enhances the stability of the estrogen receptor. J Biol Chem. 2001;276:17354-60.
  • Kim SH, Li Z, Sacks DB. E-cadherin-mediated cell-cell attachment activates Cdc42. J Biol Chem 2000; 275: 36999-37005.
  • Li Z, Joyal JL, Sacks DB. Binding of IRS proteins to calmodulin is enhanced in insulin resistance. Biochemistry 2000; 39:5089-5096.
  • Li Z, Kim SH, Higgins JMG, Brenner MB, Sacks DB. IQGAP1 and calmodulin modulate E-cadherin function. J Biol Chem 1999; 274:37885-37892.
  • Ho Y-D, Joyal JL, Li Z, Sacks DB. IQGAP1 integrates Ca2+/calmodulin and Cdc42 signaling. J Biol Chem 1999; 274:464-470.
  • Joyal JL, Burks DJ, Pons S, Matter WF, Vlahos CJ, White MF, Sacks DB. Calmodulin activates phosphatidylinositol 3-kinase. J Biol Chem 1997; 272:28183-28186.
  • Joyal JL, Annan RA, Ho YD, Huddleston ME, Carr SA, Hart MJ, Sacks DB. Calmodulin modulates the interaction between IQGAP1 and Cdc42: Identification of IQGAP1 by nanoelectro-spray tandem mass spectrometry. J Biol Chem 1997; 272:15419-15425.
  • Munshi HG, Burks DJ, Joyal JL, White MF, Sacks DB.CA2+ regulates calmodulin binding to IQ motifs in IRS-1. Biochemistry 1996; 35:1-5883-1588-9.
  • Antman EM, Grudzien C, Sacks DB. Evaluation of a rapid bedside assay for the detection of serum cardiac tro-ponin T. JAMA 1995; 273:-1279-1282.
  • Joyal JL, Sacks DB. Insulin-dependent phosphorylation of calmodulin in rat hepatocytes. J Biol Chem 1994; 269:30039-30048.
  • Tanasijevic MJ, Myers MG Jr, Thoma RS, Crimmins DL, White MF, Sacks DB. Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II. J Biol Chem 1993; 268:18157-18166.
  • Reddy GP, Reed WC, Sheehan EL, Sacks DB. Calmodulin-specific monoclonal antibodies inhibit DNA replication in mammalian cells. Biochemistry 1992; 31:10426-10430.
  • Sacks DB, Davis HW, Crimmins DL, McDonald JM. Insulin-stimulated phosphorylation of calmodulin. Biochem J 1992; 286:211-216.
  • Sacks DB, Porter SE, Ladenson JH, McDonald JM. Monoclonal antibody to calmodulin: Development, characterization and comparison with polyclonal anti-calmodulin antibodies. Anal Biochem 1991; 194:369-377.
  • Sacks DB, Fujita-Yamaguchi Y, Gale RD, McDonald JM. Tyrosine-specific phosphoryla-tion of calmodulin by the insulin receptor kinase purified from human placenta. Biochem J 1989; 263:803-812.
  • Sacks DB, McDonald JM. Insulin-stimulated phosphorylation of calmodulin by rat liver insulin receptor preparations. J Biol Chem 1988; 263:2377-2383.

Reviews

  • Sacks DB. Carbohydrates. In: Rifai N, Chiu RW, Young IS, Burnham CA, Wittwer CT, editors. Tietz textbook of clinical chemistry and molecular diagnostics. 7th ed. St. Louis: Elsevier Saunders, 2021, in the press.
  • Sacks DB. Diabetes mellitus. In: Rifai N, Chiu RW, Young IS, Burnham CA, Wittwer CT, editors. Tietz textbook of clinical chemistry and molecular diagnostics. 7th ed. St. Louis: Elsevier Saunders, 2021, in the press.
  • Hedman AH, Sacks DB.  Cadherin signaling. In: Jez J, editor.  Encyclopedia of Biological Chemistry.  Vol. 3.  San Diego: Academic Press/Elsevier Science, 2021, in the press.
  • Hedman AH, Sacks DB.  Adaptor proteins.  In: Offermanns S, Rosenthal W, editors.  Encyclopedia of Molecular Pharmacology.  3rd ed.  Berlin: Springer, 2020.
  • Little RR, Rohlfing CL, Sacks DB. The National Glycohemoglobin Standardization Program: Over 20 years of improving hemoglobin A1c measurement [Review]. Clin Chem 2019; 65:839-848.
  • O’Brien MJ, Sacks DB. Point-of-care hemoglobin A1c. JAMA 2019; 322:1404-1405.
    [Highlighted in “In This Issue of JAMA”]
  • Sacks DB. Carbohydrates. In: Rifai N, Horvath AR, Wittwer CT, editors. Tietz textbook of clinical chemistry and molecular diagnostics. 6th ed. St. Louis: Elsevier Saunders, 2018. p.  518-538.
  • Sacks DB. Diabetes mellitus. In: Rifai N, Horvath AR, Wittwer CT, editors. Tietz textbook of clinical chemistry and molecular diagnostics. 6th ed. St. Louis: Elsevier Saunders, 2018. p.  1160-1200.
  • Hedman AC, Sacks DB. IQGAP. In Choi S, editor. Encyclopedia of Signaling Molecules. 2nd ed. Springer, 2018: 2718-2724.
  • Selvin E, Sacks DB. Variability in the relationship of HbA1c and average glucose concentrations: How much does race matter? [Editorial]. Ann Intern Med 2017; 167:131-132.
  • Welsh KJ, Kirkman MS, Sacks DB. Role of glycated proteins in the diagnosis and management of diabetes: research gaps and future directions [Perspective]. Diabetes Care 2016; 39;1299-1306.
    [Highlighted in “In This Issue”]
  • Sacks DB. Carbohydrates. In: Burtis CA, Bruns DE, editors. Tietz fundamentals of clinical chemistry and molecular diagnostics.  7th ed.  St. Louis: Elsevier Saunders, 2015. p. 376-387.
  • Sacks DB. Diabetes mellitus. In: Burtis CA, Bruns DE, editors. Tietz fundamentals of clinical chemistry and molecular diagnostics.  7th ed.  St. Louis: Elsevier Saunders, 2015. p. 608-631.
  • Hedman AC, Smith JM, Sacks DB. The biology of IQGAP proteins: beyond the cytoskeleton [Review]. EMBO reports. 2015; 16:427-446.
  • Smith JM, Hedman AC, Sacks DB. IQGAPs choreograph cellular signaling from the membrane to the nucleus [Review]. Trends Cell Biol 2015; 25:171-184.
  • Sacks DB. Diagnosis of gestational diabetes mellitus: it is time for international consensus [Opinion]. Clin Chem 2014; 60:141-143.
  • Sacks DB. Endocrine responses and testing in acute medical and critical illness. In: Matfin G, editor. Endocrine and Metabolic Medical Emergencies. Washington, DC: Endocrine Press, The Endocrine Society, 2014. p. 14-17.
  • Sacks DB, John WG. Interpretation of hemoglobin A1c values [Viewpoint]. JAMA 2014; 311:2271-2272.
  • Sacks DB. Hemoglobin A1c in diabetes: Panacea or pointless? [Commentary] Diabetes 2013; 62:41-43.
  • Sacks DB. Cadherin signaling. In: Lennarz WJ, Lane MD, editors.  Encyclopedia of Biological Chemistry, 2nd edition.  Vol. 1.  San Diego: Academic Press/Elsevier Science, 2013. p. 261-264.
  • Sacks DB. Measurement of hemoglobin A1c: A new twist on the path to harmony [Review]. Diabetes Care 2012; 35:2674-2680.
  • White CD, Erdemir HE, Sacks DB. IQGAP1 and its binding partners control diverse biological functions [Review]. Cell Signal 2012; 24:826-834.
  • Kim H, White CD, Sacks DB. IQGAP1 in microbial pathogenesis: Targeting the actin cytoskeleton [Review]. FEBS Lett 2011; 585:723-729.
  • White CD, Brown MD, Sacks DB. IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis [Review]. FEBS Lett 2009; 583:1817-1824. PMCID: PMC2743239.
  • Brown MD, Sacks DB. Protein scaffolds in MAP kinase signalling [Review]. Cell Signal 2009; 21:462-469. PMCID: PMC2668224
  • Saudek CP, Herman WH, Sacks DB, Bergenstal RM, Edelman D, Davidson MB. A new look at screening for and diagnosing diabetes mellitus [Review]. J Clin Endocrinol Metab 2008; 93:2447-2453.
  • Li L, Sacks DB. Functional interactions between calmodulin and estrogen receptor-α [Review]. Cell Signal 2007; 19:439-443.
  • Brown MD, Sacks DB. IQGAP1 in cellular signalling: bridging the GAP [Review]. Trends Cell Biol 2006; 16:242-249.
  • Goldstein DE, Little RR, Lorenz RA, Malone JI, Nathan D, Peterson CM, Sacks DB. Tests of glycemia in diabetes. Diabetes Care 2004; 27:1761-1773.
  • Briggs MW, Sacks DB. IQGAP proteins are integral components of cytoskeletal regulation [Review]. EMBO reports 2003; 4:571-574.
  • Briggs MW, Sacks DB. IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton [Review]. FEBS Lett 2003; 542:7-11.
  • Sacks DB, McDonald JM. The pathogenesis of type II diabetes mellitus: a polygenic disease [Review]. Am J Clin Pathol 1996; 105:­149-156.

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