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Department of Laboratory Medicine

David B. Sacks, MB ChB Curriculum Vitae

Dr. David B. Sacks is the Senior Investigator.

Work Address

NIH Clinical Center
Department of Laboratory Medicine
Bldg 10, Rm 2C306
10 Center Drive
Bethesda, MD 20892
Phone: 301-496-3386
Fax: 301-402-1885

Selected Bibliography

Research Investigations

  • Li Z, Zhang Y, Hedman AC, Ames JB, Sacks DB. Calmodulin lobes facilitate dimerization and activation of estrogen receptor-α. J Biol Chem 2017; 292:4614-4622.
  • Chawla B, Hedman AC, Sayedyahossein S, Erdemir HH, Li Z, Sacks DB. Absence of IQGAP1 protein leads to insulin resistance. J Biol Chem 2017; 292:3273-3289.
  • Choi S, Hedman A, Sayedyahossein S, Thapa S, Sacks DB, Anderson R. Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases. Nature Cell Biol 2016; 18:1324-1335.
  • LeCour L, Boyapati VK, Liu J, Li Z, Sacks DB, Worthylake DK. The structural basis for Cdc42-induced dimerization of IQGAPs. Structure 2016; 24:1499-1508.
  • Sayedyahossein S, Li Z, Hedman AC, Morgan CJ, Sacks DB. IQGAP1 binds to Yes-associated protein (YAP) and modulates its transcriptional activity. J Biol Chem 2016; 291:19261-19273.
  • Bessede E, Molina S, Amador LA, Dubus P, Staedel C, Chambonnier L, Buissoniere A, Sifre E, Giese A, Benejat L, Rousseau B, Costet P, Sacks DB, Megraud F, Varon C. Deletion of IQGAP1 promotes Helicobacter pylori-induced gastric dysplasia in mice and acquisition of cancer stem cell properties in vitro. Oncotarget 2016; 7:80688-80699.
  • Lu R, Herrera BB, Eshleman H, Fu Y, Bloom A, Li Z, Sacks DB, Goldberg MB. Shigella effector OspB activates mTORC1 in a manner that depends on IQGAP1 and promotes cell proliferation. PLoS Pathog 2015; 11(10): e1005200. doi: 10.1371/journal.ppat.1005200
  • Tian Y, Gawlak G, Shah AS, Higginbotham K. Tian X, Kawasaki Y, Akiyama T, Sacks DB, Birukova AA. HGF-induced Asef-IQGAP1complex controls cytoskeletal remodeling and endothelial barrier. J Biol Chem 2015; 290:4097-4109.
  • Tanos BE, Perez Bay AE, Salvarezza S, Vivanco I, Mellinghoff I, Osman M, Sacks DB, Rodriguez-Boulan E. IQGAP1 controls tight junction formation through differential regulation of claudin recruitment. J Cell Sci 2015; 128:853-862. [Highlighted on cover and “In This Issue”]
  • Erdemir HH, Li Z, Sacks DB. IQGAP1 binds to estrogen receptor-α and modulates its function. J Biol Chem 2014; 289:9100-9112.
  • Tian Y, Tian X, Gawlak G, O'Donnell J, Sacks DB, Birukova AA. IQGAP1 regulates endothelial barrier function via EB1-cortactin cross talk. Mol Cell Biol 2014; 34:3456-3558.
  • Fram S, King H, Sacks DB, Wells CM. A PAK6:IQGAP1 complex promotes disassembly of cell:cell adhesions. Cell Mol Life Sci 2014; 71:2759-2773.
  • Witze ES, Houel S, Schwartz MP, Morphew MK, Reaid L, Sacks DB, Anseth KS, Ahn NG. Wnt5a directs polarized calcium gradients by recruiting cortical endoplasmic reticulum to the cell trailing edge. Dev Cell 2013; 26:645-657.
  • Choi S, Thapa N, Hedman AC, Li Z, Sacks DB, Anderson RA. IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration. EMBO J 2013; 32:2617-2630.
  • Cheung KL, Lee JH, Shu L. Kim JH, Sacks DB, Kong AN. The Ras GTPase-activating-like protein IQGAP1 mediates Nrf2 protein activation via the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)-ERK pathway. J Biol Chem 2013; 288:22378-22386.
  • Kim JH, Xu EY, Sacks DB, Lee J, Shu L, B Xia B, Kong AN. Identification and functional studies of a new Nrf2 partner IQGAP1: A critical role in the stability and transactivation of Nrf2. Antioxid Redox Signal 2013; 19:89-101.
  • Lee GS, Subramanian N, Kim A, Aksentijevich I, Goldbach-Mansky R, Sacks DB, Germain RN, Kastner DL, Chae JJ. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 2012, 492:123-127.
  • Zhang Y, Li Z, Sacks DB, Ames JB. Structural basis for Ca2+-induced activation and dimerization of estrogen receptor α by calmodulin. J Biol Chem 2012; 287:9336-9344. [Journal of Biological Chemistry Paper of the Week] [Recommended by the Faculty of 1000]
  • Logue JS, Whiting JL, Tunquist B, Sacks DB, Langeberg LK, Wordeman L, Scott JD. AKAP220 protein organizes signaling elements that impact cell migration. J Biol Chem 2011; 286:39269-39281.
  • Kim H, White CD, Li Z, Sacks DB. Salmonella enterica serotype Typhimurium usurps the scaffold protein IQGAP1 to manipulate Rac1 and MAPK signalling. Biochem J 2011; 440:309-318.
  • White CD, Li Z, Dillon DA, Sacks DB. IQGAP1 binds human epidermal growth factor receptor 2 (HER2) and modulates trastuzumab resistance. J Biol Chem 2011; 286:29734-29747. [Recommended by the Faculty of 1000]
  • Sharma S, Findlay GM, Bandukwala HS, Oberdoerffer S, Baust B, Li Z, Schmidt V, Hogan PG, Sacks DB, Rao A. Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc Natl Acad Sci USA 2011; 108:11381-11386.
  • McNulty DE, Li Z, White CD, Sacks DB, Annan RS. MAP kinase scaffold IQGAP1 binds the EGF receptor and modulates its activation. J Biol Chem 2011; 286:15010-15021.
  • McLaughlin LM, Govoni G, Gerke C, Gopinath S, Peng K, Laidlaw G, Chien Y-H, Jeong H-W, Li Z, Brown MD, Sacks DB, Monack D. The Salmonella effector SseI mediates long-term systemic systemic infection by modulating host cell migration. PLOS Pathog 2009; 5 (11):e1000671.
  • Brown MD, Bry L, Li Z, Sacks DB. Actin pedestal formation by EPEC is regulated by IQGAP1, calcium and calmodulin. J Biol Chem 2008; 283: 35212-35222.
  • Ren JG, Li Z, Sacks DB. IQGAP1 integrates Ca2+/calmodulin and B-Raf signaling. J Biol Chem 2008; 283:22972-22982.
  • Owen D, Campbell LJ, Littlefield K, Evetts KA, Li Z, Sacks DB, Lowe PN, Mott HR. The IQGAP1-Rac1 and IQGAP1-Cdc42 interactions: interfaces differ between the complexes. J Biol Chem 2008; 283:1692-1704.
  • Jadeski L, Mataraza JM, Jeong HW, Li Z, Sacks DB. IQGAP1 stimulates proliferation and enhances tumourigenesis of human breast epithelial cells. J Biol Chem 2008; 283:1008-1017.\
  • Brown MD, Bry L, Li Z, Sacks DB. IQGAP1 regulates Salmonella invasion through interactions with actin, Rac1 and Cdc42. J Biol Chem 2007; 282:30265-30272.
  • Jeong HW, Li Z, Brown MD, Sacks DB. IQGAP1 binds Rap1 and modulates its activity. J Biol Chem 2007; 282:20752-20762.
  • Ren JG, Li Z, Sacks DB. IQGAP1 modulates activation of B-Raf. Proc Natl Acad Sci USA 2007; 104:10465-10469.
  • Li L, Li Z, Howley PM, Sacks DB. E6AP and calmodulin reciprocally regulate estrogen receptor stability. J Biol Chem 2006; 281:1978-1985.
  • Roy M, Li Z, Sacks DB. IQGAP1 is a scaffold for mitogen-activated protein kinase signaling. Mol Cell Biol 2005; 25:7940-7952.
  • Ren JG, Li Z, Crimmins DL, Sacks DB. Self association of IQGAP1: Characterization and functional sequelae. J Biol Chem 2005; 280:34548-34557.
  • Li Z, McNulty DE, Marler KJM, Lim L, Hall C, Annan RS, Sacks DB. IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner. J Biol Chem 2005; 280:13871-13878.
  • Li L, Li Z, Sacks DB. The transcriptional activity of estrogen receptor-α is dependent on Ca2+/calmodulin. J Biol Chem 2005; 280:13097-13104.
  • Roy M, Li Z, Sacks DB. IQGAP1 binds ERK2 and modulates its activity. J Biol Chem 2004; 279:17329-17337.
  • Mataraza JM, Briggs MW, Li Z, Entwistle A, Ridley AJ, Sacks DB. IQGAP1 promotes cell motility and invasion. J Biol Chem 2003; 278:41237-41245.
  • Li Z, Sacks DB. Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1. J Biol Chem 2003; 278:4347-4352.
  • Li L, Li Z, Sacks DB. Calmodulin regulates the transcriptional activity of estrogen receptors: selective inhibition of calmodulin function in subcellular compartments. J Biol Chem 2003; 278:1195-1200.
  • Sacks DB, Bruns DE, Goldstein DE, Maclaren NK, McDonald JM, Parrott M. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clin Chem 2002; 48:436-472. [Published concurrently in Diabetes Care 2002; 25:750-786.]
  • Swart-Mataraza JM, Li Z, Sacks DB. IQGAP1 is a component of Cdc42 signaling to the cytoskeleton. J Biol Chem 2002; 277:24753-24763.
  • Briggs MW, Li Z, Sacks DB. IQGAP1-mediated stimulation of transcriptional co-activation by β- catenin is modulated by calmodulin. J Biol Chem 2002; 277:7453-7465.
  • Sokol SY, Li Z, Sacks DB. The effect of IQGAP1 on Xenopus embryonic ectoderm requires Cdc42. J Biol Chem. 2001;276:48425-30.
  • Li Z, Joyal JL, Sacks DB. Calmodulin enhances the stability of the estrogen receptor. J Biol Chem. 2001;276:17354-60.
  • Kim SH, Li Z, Sacks DB. E-cadherin-mediated cell-cell attachment activates Cdc42. J Biol Chem 2000; 275: 36999-37005.
  • Li Z, Joyal JL, Sacks DB. Binding of IRS proteins to calmodulin is enhanced in insulin resistance. Biochemistry 2000; 39:5089-5096.
  • Li Z, Kim SH, Higgins JMG, Brenner MB, Sacks DB. IQGAP1 and calmodulin modulate E-cadherin function. J Biol Chem 1999; 274:37885-37892.
  • Ho Y-D, Joyal JL, Li Z, Sacks DB. IQGAP1 integrates Ca2+/calmodulin and Cdc42 signaling. J Biol Chem 1999; 274:464-470.
  • Joyal JL, Burks DJ, Pons S, Matter WF, Vlahos CJ, White MF, Sacks DB. Calmodulin activates phosphatidylinositol 3-kinase. J Biol Chem 1997; 272:28183-28186.
  • Joyal JL, Annan RA, Ho YD, Huddleston ME, Carr SA, Hart MJ, Sacks DB. Calmodulin modulates the interaction between IQGAP1 and Cdc42: Identification of IQGAP1 by nanoelectro-spray tandem mass spectrometry. J Biol Chem 1997; 272:15419-15425.
  • Munshi HG, Burks DJ, Joyal JL, White MF, Sacks DB.CA2+ regulates calmodulin binding to IQ motifs in IRS-1. Biochemistry 1996; 35:1-5883-1588-9.
  • Antman EM, Grudzien C, Sacks DB. Evaluation of a rapid bedside assay for the detection of serum cardiac tro-ponin T. JAMA 1995; 273:-1279-1282.
  • Joyal JL, Sacks DB. Insulin-dependent phosphorylation of calmodulin in rat hepatocytes. J Biol Chem 1994; 269:30039-30048.
  • Tanasijevic MJ, Myers MG Jr, Thoma RS, Crimmins DL, White MF, Sacks DB. Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II. J Biol Chem 1993; 268:18157-18166.
  • Reddy GP, Reed WC, Sheehan EL, Sacks DB. Calmodulin-specific monoclonal antibodies inhibit DNA replication in mammalian cells. Biochemistry 1992; 31:10426-10430.
  • Sacks DB, Davis HW, Crimmins DL, McDonald JM. Insulin-stimulated phosphorylation of calmodulin. Biochem J 1992; 286:211-216.
  • Sacks DB, Porter SE, Ladenson JH, McDonald JM. Monoclonal antibody to calmodulin: Development, characterization and comparison with polyclonal anti-calmodulin antibodies. Anal Biochem 1991; 194:369-377.
  • Sacks DB, Fujita-Yamaguchi Y, Gale RD, McDonald JM. Tyrosine-specific phosphoryla-tion of calmodulin by the insulin receptor kinase purified from human placenta. Biochem J 1989; 263:803-812.
  • Sacks DB, McDonald JM. Insulin-stimulated phosphorylation of calmodulin by rat liver insulin receptor preparations. J Biol Chem 1988; 263:2377-2383.


  • Hedman AC, Smith JM, Sacks DB. The biology of IQGAP proteins: beyond the cytoskeleton [Review]. EMBO reports. 2015; 16:427-446.
  • Smith JM, Hedman AC, Sacks DB. IQGAPs choreograph cellular signaling from the membrane to the nucleus [Review]. Trends Cell Biol 2015; 25:171-184.
  • Sacks DB. Cadherin signaling. In: Lennarz WJ, Lane MD, editors.  Encyclopedia of Biological Chemistry, 2nd edition.  Vol. 1.  San Diego: Academic Press/Elsevier Science, 2013. p. 261-264.
  • White CD, Erdemir HE, Sacks DB. IQGAP1 and its binding partners control diverse biological functions [Review]. Cell Signal 2012; 24:826-834.
  • Kim H, White CD, Sacks DB. IQGAP1 in microbial pathogenesis: Targeting the actin cytoskeleton [Review]. FEBS Lett 2011; 585:723-729.
  • White CD, Brown MD, Sacks DB. IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis [Review]. FEBS Lett 2009; 583:1817-1824. PMCID: PMC2743239.
  • Brown MD, Sacks DB. Protein scaffolds in MAP kinase signalling [Review]. Cell Signal 2009; 21:462-469. PMCID: PMC2668224
  • Saudek CP, Herman WH, Sacks DB, Bergenstal RM, Edelman D, Davidson MB. A new look at screening for and diagnosing diabetes mellitus [Review]. J Clin Endocrinol Metab 2008; 93:2447-2453.
  • Li L, Sacks DB. Functional interactions between calmodulin and estrogen receptor-α [Review]. Cell Signal 2007; 19:439-443.
  • Brown MD, Sacks DB. IQGAP1 in cellular signalling: bridging the GAP [Review]. Trends Cell Biol 2006; 16:242-249.
  • Goldstein DE, Little RR, Lorenz RA, Malone JI, Nathan D, Peterson CM, Sacks DB. Tests of glycemia in diabetes. Diabetes Care 2004; 27:1761-1773.
  • Briggs MW, Sacks DB. IQGAP proteins are integral components of cytoskeletal regulation [Review]. EMBO reports 2003; 4:571-574.
  • Briggs MW, Sacks DB. IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton [Review]. FEBS Lett 2003; 542:7-11.
  • Sacks DB, McDonald JM. The pathogenesis of type II diabetes mellitus: a polygenic disease [Review]. Am J Clin Pathol 1996; 105:­149-156.

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