Skip to main content

Patient Recruitment

NIH Severe Aplastic Anemia Study

Researching a More Effective Treatment to Prevent Relapse for Severe Aplastic Anemia (SAA)

test tube above text that reads Aplastic Anemia

medical illustration depicting a close-up of red cells

Severe aplastic anemia is a rare and serious blood disorder. Patients with severe aplastic anemia commonly receive Cyclosporine to help improve blood counts. When cyclosporine treatment stops, the disease may return in one in three people.

Researchers at the National Institutes of Health (NIH) Clinical Center in Bethesda, Maryland are studying if sirolimus, an immunosuppressant, can help prevent a relapse in patients diagnosed with severe aplastic anemia following cyclosporine treatment.

What is involved?

  • Randomly assigned to two groups:
    • One group taking cyclosporine and receive sirolimus for 3 months;
    • Second group will stop taking cyclosporine and not receive any medication but will be closely monitored
  • A full medical history, physical examination, and bone marrow biopsy
  • Participation in this study may last up to five years
  • Received study related medication, tests, and procedures at no cost

To be eligible for this study, you must:

  • Be 2 years or older
  • Have responded to immunosuppressive therapy that includes cyclosporine and continue on cyclosporine

The study takes place at the NIH Clinical Center. We are on the Metro red line (Medical Center stop).

For more information, contact:
NIH Clinical Center Office of Patient Recruitment
800-411-1222 (refer to #17-H-0019)
800-877-8339 TTY / ASCII
Se habla español

Or go online:

Department of Health and Human Services
National Institutes of Health Clinical Center (CC)
National Heart, Lung and Blood Institute (NHLBI)

NOTE: PDF documents require the free Adobe Reader.

This page last updated on 10/22/2021

You are now leaving the NIH Clinical Center website.

This external link is provided for your convenience to offer additional information. The NIH Clinical Center is not responsible for the availability, content or accuracy of this external site.

The NIH Clinical Center does not endorse, authorize or guarantee the sponsors, information, products or services described or offered at this external site. You will be subject to the destination site’s privacy policy if you follow this link.

More information about the NIH Clinical Center Privacy and Disclaimer policy is available at