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Medical Milestones - Clinical Center Firsts


  1. McCarthy CR. The origins and policies that govern institutional review boards. In: Emmanuel EJ, Lie RK, Grady C, et al. The Oxford Textbook of Clinical Research Ethics. New York, NY: Oxford University Press; 2008: 541-558.

  2. Hilbish TF. Developments in Diagnostic Radiology. Public Health Reports. 1954, 1020-27.

  3. Breacher G, Schniederman M, Williams GZ. Evaluation of electronic red blood cell counter. American J Clin Path. 1956, 26: 1439-49.

  4. Li MC, Hertz R, Bergenstal DM. Therapy of choriocarcinoma and related trophoblastic tumors with folic acid and purine agonists. N Eng J Med. 1958, 259: 66-74.

  5. Braunwald NS, Cooper T, Morrow AG. Complete replacement of the mitral valve. Successful clinical application of a flexible polyurethane prosthesis J Thoracic Cardiovasc Surg. 1960, 40: 1-11.

  6. Fredrickson DS, Altrocchi PH, Avioli LV, et al. Tangier disease: Combined Clinical Staff Conference at NIH. Ann Intern Med. 1961;55:1016-31.

  7. Kliman A, Gaydos LA, Schroeder LR, et al. Repeated plasmapherisis of blood donors as a source of platelets. Blood. 1961, 18: 303-9.

  8. Nirenberg, Marshall W. "The Genetic Code: II." Scientific American. 1963, 208: 80-94.

  9. Ommaya AK. Subcutaneous reservoir and pump for sterile access to ventricular cerebrospinal fluid. Lancet. 1963, 282: 983-84.

  10. Englander HR, Keyes PH, Getswicki M et al. Clinical anticaries effect of repeated topical sodium fluoride applications by mouthpieces. JADA. 1967, 75: 638–644.

  11. Doppman JL, Chiro DG. Subtraction-Angiography of Spinal Cord Vascular Malformations. J Nuerosurgery. 1965, 23: 440-43.

  12. Freirdreich EJ, Judson G, and Levin RH. Special collection of leukocytes. Cancer Res. 1965, 25: 1516-20.

  13. Chappell WS. Platelet Concentrates from Acidified Plasma: A Method of Preparation Without the Use of Additives. Transfusion. 1966, 6:308-9. 

  14. Doppman JL, Hammond WG, Melson GL, et al. Staining of parathyroid adenomas by selective arteriography. Radiology. 1969, 92, 527-530.

  15. Goodwin FK, Murphy DL and Bunney WE. Lithium-carbonate treatment in depression and mania. Arch Gen Psychiat. 1969, 21: 486-96.

  16. Lander JJ, Alter HJ, and Purcell RH. Frequency of antibody to hepatitis-associated antigen as measured by a new radioimmunoassay technique. J Immun. 1971, 106: 1166-71.

  17. Graw RG, Herzig G, Perry S, et al. Normal granulocyte transfusion therapy. NEJM. 1972, 287: 366-71.

  18. Gavin JR, Roth J, Jen P, et al. Insulin receptors in human circulating cells and fibroblasts. PNAS. 1972, 69: 747-51.

  19. Dinarello CA, Goldin NP, Wolff SM. Demonstration and Characterization of two distinct human leukocytic pyrogens. J Experimental Med. 1974, 139: 1369-80.

  20. Borer JS, Redwood DR, Levitt B, et al. Reduction in myocardial ischemia with nitroglycerin or nitroglycerin plus phenylephrine administered during acute myocardial infarction. NEJM. 1975, 293: 1008-12. 

  21. Lewis TL, and Macks GC. Adaptation of a general hospital computerized medical information system to the research hospital environment. Proc Annu Symp Comput Appl Med Care. 1977, Oct 5: 111-15.

  22. Dinarello CA, Refner L and Wolff SM. Human leukocytic pyrogen: purification and development of a radioimmunoassay. PNAS. 1977, 74:4624-27.

  23. Fauci AS, Katz P, Haynes BF. Cyclophosphamide therapy of severe systemic necrotizing vasculitis. NEJM. 1979, 301: 235-238.

  24. Buschbaum MS, Ingvar DH, Kessler R, et al. Cerebral glucography with positron tomography. Arch Gen Psychiatry. 1982, 39: 251-59.

  25. Steinherz R, Tietze F, Raiford D, et al. Patterns of amino acid efflux from isolated normal and cystinotic human leukocyte lysosomes. J Biol Chem. 1982, 257: 6041-49.

  26. Bowen DL, Lane HC, and Fauci AS. Immunopathogenesis of the acquired immunodeficiency syndrome. Ann Internal Med. 1985, 103:704-9.

  27. Weiss SH, Goedert JJ, Samgadharan MG, et al. Screening test for htlv-iii (aids agent) antibodies. JAMA. 1985, 221-25.

  28. Rosenburg SA, Lotze MT, Muul LM, et al. Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. NEJM. 1985, 313:1485-92.

  29. Flament MF, Rapoport JL, Berg CJ. Clomipramine treatment of childhood obsessive-compulsive disorder. Arch Gen Psychiatry. 1985, 42:977-83.

  30. Castelli WP, Garrison RJ, Wilson PWF, Abbott RD et al. Incidence of coronary heart disease and lipoprotein cholesterol levels. JAMA. 1986, 256: 2835-38.

  31. Alexander DF. Why should there be an NICHD. Pediatrics. 2011, 127: 325 -333.

  32. Zbar B, Brauch H, Talmadge C, et al. Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma. Nature. 1987, 327: 721-24.

  33. Gahl WA, Reed GF, Thoene JG, et al. Cysteamine therapy for children with nephropathic cystinosis. NEJM. 1987, 316: 971-79.

  34. Mitsuya H, Weinhold, Furman PA, et al. 3’-azido-3’-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. PNAS. 1985, 82: 7096-100.

  35. Yarchoan R Weinhold KJ, Lyerly HK, et al. Administration of 3’azido-3’-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex. Lancet. 1986, 327: 575-80.

  36. Rosenburg SA, Packard BS, Aebersold PM. Use of tumor-infiltrating lympohcytes and interleukin-2 in immunotherapy of patients with metastatic melanoma. NEJM. 1988, 319: 1676-80. 

  37. Altschul SF, Gish W, Miller W, et al. Basic Local Alignment Search Tool. J Mol Biol. 1990. 215:403-10.

  38. Blaese RM, Culver KW, Miller D, et al. T Lymphocyte-directed gene therapy for ADA-SCID: initial trial results after 4 years. Science. 1995, 270: 475-80.

  39. Yarchoan R, Mitsuya H, Pluda JM, et al. The National Cancer Institute Phase I study of 2’, 3’-dideoxyinosine administration in adults with AIDS or AIDS-related complex: analysis of acticity and toxicity profiles. Rev of Infectious Diseases. 1990, 12 522-33.

  40. Barton NW, Brady RO, Dambrosia JM, et al. Replacement therapy for inherited enzyme deficiency—macrophage-targeted glucocerebrosidase for Gaucher’s disease. NEJM. 1991, 324: 1464-70.

  41. Latif FL, Tory K, Gnarra J, et al. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science. 1993, 260: 1317-20.

  42. Kirnbauer R, Taub Jm Greenstone H, et al. Efficient self-assembly of human papillomavirus type 16 L1 and L1-L2 into virus-like particles. J Virology. 1993, 67: 6929-6936.

  43. Waldmann TA, White JD, Goldman Ck, et al. The interleukin-2 receptor: a target for monoclonal antibody treatment of human T-Cell lymphotrophic virus I-induced adult T-cell leukemia. Blood. 1993, 82:1701-1712.

  44. Frazier JA, Gordon CT, McKenna K, et al. An open trial of clozapine in 11 adolescents with childhood-onset schizophrenia. J Am Child Adolesc Psychiatry. 1994, 33:658-663.

  45. Rosenburg SA, Yanelli JR, Yang JC, et al. Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2. J National Cancer Institute. 1994, 86: 1159-66.

  46. Martin DF, Parks DJ, Mellow SD, et al. Treatment of cytomegalovirus retinis with an intraocular sustained-release ganciclovir implant. Arch Ophthalmol. 1994, 112: 1531–39.

  47. Rosenfield SJ, Kimball J, Vining D, et al. Intensive immunosuppression with antithymocyte globulin and cyclosporine as treatment for sever acquired aplastic anemia. Blood. 1995, 85: 3058-65. 

  48. Swedo SE, Leonard HL, Garvey M, et al. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases. Am J Psychiatry. 1998, 155: 264-71.

  49. Childs R, Chernoff A, Contentin N, et al. Regression of Metastatic renal-cell carcinoma after nonmyeloblative allogeneic peripheral-blood stem-cell transplantation. NEJM. 2000, 343: 750-8.

  50. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins c and e, beta carotene, and zinc for age-related macular degeneration and vision loss. Arch Opthalmol. 2001, 119: 1417-1436.

  51. Schmidt LS, Warren MB, Nickerson ML, et al. Birt-Hogg-Dube syndrome, a genodermatosis associated with spontaneous pneumothorax and kidney neoplasia, maps to chromosome 17p11.2. Am J Hum Genet. 2001, 69: 876-882.

  52. Kreitman RJ, Wilson WH, Bergeron K, et al. Efficacy of the anti-cd22 recombinant immunotoxin bl22 in chemotherapy-resistant hairy-cell l leukemia. NEJM. 2001, 345: 241-247.

  53. Oral EA, Simha V, Ruiz E, et al. Leptin-replacement therapy for lipodystrophy. NEJM. 2002, 346: 570-578. 

  54. Lee JS, Fitzgibbon E, Butman JA, et al. Normal vision despite narrowing of the optic canal in fibrous dysplasia. NEJM. 2002, 347: 1670-76.

  55. Kwong RY, Schussheim AE, Rekhraj, et al. Detecting acute coronary syndrome in the emergency department with cardiac magnetic resonance imaging. Circulation. 2003, 107: 531-37.

  56. Leibenluft E, Charney DS, Towbin KE, et al. Defining clinical phenotypes of juvenile mania. Am J Psychiatry. 2003, 160: 430-37.

  57. Kwong RY, Schussheim AE, Rekhraj S, et al. Detecting acute coronary syndrome in the emergency department with cardiac magnetic resonance imaging. Circulation. 2003, 107: 531-537.

  58. Oxman MN, Levin MJ, Johnson GR, et al. A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults. N Engl J Med 2005;352:2271-84

  59. Wei MI, Toure I, Glenn GM, et al. Novel mutations in FH and expansion of the spectrum of phenotypes expressed in families with hereditary leiomyomatosis and renal cell cancer. J Med Genet. 2006, 43: 18-27. 

  60. Summers RM, Yao J, Pickhardt PJ, et al. Computed Tomographic Virtual Colonoscopy Computer-Aided Polyp Detection in a Screening Population. Gastroenterology. 2005, 129: 1832-44.

  61. Zarate CA, Singh JB, Carlson PJ, et al. A randomized trial of an n-methyl-d-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry. 2006, 63: 856-864.

  62. Pinto PA, Chung PH, Rastinehad AR, et al. Magnetic resonance imaging/ultrasound fusion guided prostate biopsy improves cancer cancer detection following transrectal ultrasound biopsy and correlates with multiparametric magnetic resonance imaging. J Urology. 2011, 186: 1281-5.

  63. Biesecker LG, Mullikin JC, Facio FM, et al. The ClinSeq Project: Piloting large-scale genome sequencing for research in genomic medicine. Genome Res. 2009, 19:1665-74.

  64. Johnson LA, Morgan RA, Dudley ME, et al. Gene Therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. Blood. 2009, 114: 535-46.

  65. Aksentijevich I, Masters SL, Ferguson PJ, et al. An autoinflammatory disease with deficiency of the interleukin-1-recptor agonist. NEJM. 2009, 360: 2426-37.

  66. Kang K, Riazuddin S, Mundorff J, et al. Mutations in the lysosomal enzyme-targeting pathway and persistent stuttering. NEJM. 2010. 362:677-85.

  67. Kochenderfer JN, Zhiya Y, Frasheri D, et al. Adoptive transfer of syngeneic t cells transduced with a chimeric antigen receptor that recognizes murine cd19 can eradicate lymphoma and normal b cells. Blood. 2010, 116: 3875-886.

  68. Robbins PF, Morgan RA, Feldman SA, et al. Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1. J Clin Oncology. 2011, 29: 917-923.

  69. Sabatino M, Jiaqiang R, David-Ocampo V, et al. The establishment of a bank of stored bone marrow stromal cell products. Translational Med. 2012, 10:1-12.

  70. Baum BJ, Alevizos I, Zheng C, et al. Early responses to adenoviral-mediated transfer of the aquaporin-1 cdna for radiation-induced salivary hypofunction. PNAS. 2012, 109: 19403-7.

  71. Schelbert EB, Cao JJ, Sigurdsson S, et al. Prevalence and prognosis of unrecognized myocardial infarction determined by cardiac magnetic resonance in older adults. JAMA. 2012;308:890-97.

  72. Olnes MJ, Scheinberg P, Calvo KR, et al. Eltrombopag and improved hematopoiesis in refractory aplastic anemia. NEJM. 2012, 367: 11-19.

  73. Ratnayaka K, Faranesh AZ, Hansen MS, et al. Real-time mri-guided right heart catheterization adults using passive catheters. European Heart J. 2013, 34: 380-9.

  74. Snitkin ES, Zelazny AM, Thomas PJ, et al. Tracking a Hospital Outbreak of Carbapenem-Resistant Klebsiella pneumoniae with Whole-Genome Sequencing. Sci Transl Med. 2012, 148:1-9.

  75. Cancer Genome Atlas Research Network et al. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature. 2013, 499: 43-9.

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