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Research at the Clinical Center

Published Clinical Research Conducted at the Clinical Center

The NIH Clinical Center is the world’s largest hospital entirely devoted to clinical research. It is a national resource that makes it possible to rapidly translate scientific observations and laboratory discoveries into new approaches for diagnosing, treating, and preventing disease.

Over 1,600 clinical research studies are conducted at the NIH Clinical Center, including those focused on cancer, infectious diseases, blood disorders, heart disease, lung disease, alcoholism and drug abuse.

Here is a sample of abstracts from the clinical research conducted at the NIH Clinical Center and published in a peer reviewed medical journal this year. Links to the full text and video formats are provided if available.


neurofilament light chain

Time Course and Diagnostic Utility of NfL, tau, GFAp, and UCH-L1 in Subacute and Chronic TBI

Published in: Neurology (July 2020)

Neurofilament light chain delivered superior diagnostic and prognostic performance as a blood biomarker for mild, moderate, and severe traumatic brain injury when compared to blood proteins glial fibrillary acidic protein, tau, and ubiquitin c-terminal hydrolase-L1.

Read the article.


neurofilament light chain as a blood biomarker

Neurofilament Light as a Biomarker in Traumatic Brain Injury

Published in: Neurology (July 2020)

Neurofilament light chain as a blood biomarker can detect brain injury and predict recovery in multiple groups, including professional hockey players with acute or chronic concussions and clinic-based patients with mild, moderate, or severe traumatic brain injury.

Read the article.


select participants

Advantages of Using Lotteries to Select Participants for High‐Demand Covid‐19 Treatment Trials

Published in: Ethics and Human Research (June 2020)

With few treatments available for Covid-19, clinical trials may be attractive for patients but unable to accommodate everyone who wants to enroll. In high-demand trials, a weighted lottery can select participants fairly and efficiently while enhancing the knowledge gained.

Read the article.


computer generated image projected on a face

Smartphone Augmented Reality CT-Based Platform for Needle Insertion Guidance: A Phantom Study

Published in: CardioVascular and Interventional Radiology (May 2020)

A smartphone application was used to superimpose computer generated images onto patients to test for improvements in needle placement for biopsy or ablation. The video-game-like augmented reality improved accuracy in a variety of phantoms.

Read the article.


targeted early chest CT

Targeted Early Chest CT in COVID-19 Outbreaks as Diagnostic Tool for Containment of the Pandemic - A Multinational Opinion

Published in: Diagnostic and Interventional Radiology (April 2020)

Researchers provide a four-nation opinion on the early use of chest CT scans as a testing tool for focal outbreaks to facilitate containment of COVID-19 and also introduce a new patient isolation bag to reduce CT contamination.

Read the article.


large surface glycoprotein

Diversity and Complexity of the Large Surface Protein Family in the Compacted Genomes of Multiple Pneumocystis Species

Published in: MBio (March 2020)

An in-depth analysis on the large surface glycoprotein superfamily in the genomes of Pneumocystis species, a major cause of disease in humans with immunodeficiency, sheds new light on how this pathogen interacts with and survives in the host.

Read the article.


computerized x-ray imaging

Automated CT Biomarkers for Opportunistic Prediction of Future Cardiovascular Events and Mortality in an Asymptomatic Screening Population

Published in: The Lancet Digital Health (March 2020)

Computerized x-ray imaging often contains unused biometric data that artificial intelligence can access and analyze to predict major cardiovascular events including heart attack, stroke, and death and overall survival with higher accuracy than routine clinical examinations.

Read the article.


machine learning algorithm

A Machine Learning Algorithm to Estimate Sarcopenia on Abdominal CT

Published in: Academic Radiology (March 2020)

A prototype of a fully-automated deep learning system to detect central sarcopenia using computed tomography scans was successfully created and validated.

Read the article.


checkpoint inhibitor therapy

Checkpoint Inhibitor Therapy in Preclinical Sepsis Models: a Systematic Review and Meta-Analysis

Published in: Intensive Care Medicine Experimental (February 2020)

AA meta-analysis of 11 animal studies suggest that additional preclinical studies are needed to show the benefit that checkpoint inhibitors add to antibiotic therapy for common bacterial infections causing sepsis.

Read the article.


man and dog sleeping

Sleep Regularity Index in Patients with Alcohol Dependence: Daytime Napping and Mood Disorders as Correlates of Interest

Published in: International Journal of Environmental Research and Public Health (January 2020)

The Sleep Regularity Index was calculated among patients with alcohol use disorder undergoing inpatient treatment and showed associations between the index, the presence of one or more mood disorders, and nap durations.

Read the article.



Chronic Mirabegron Treatment Increases Human Brown Fat, HDL Cholesterol, and Insulin Sensitivity

Published in: Journal of Clinical Investigation (January 2020)

A small study of healthy women treated for four weeks with a beta 3 adrenergic receptor agonist showed increases in metabolic activity of brown fat, HDL-cholesterol, insulin sensitivity, and bile acids, which help digest fats and regulate cholesterol.

Read the article.


ebola virus

Ebola Virus in the Democratic Republic of the Congo: Advances and Remaining Obstacles in Epidemic Control, Clinical Care, and Biomedical Research

Published in: Chest (January 2020)

The Ebola virus disease epidemic in the Congo remains uncontrolled with a high fatality rate despite advances in vaccine availability and use, improved clinical care within Ebola treatment units, and implementation of a research clinical trial evaluating targeted therapies.

Read the article.

NOTE: PDF documents require the free Adobe Reader.

This page last updated on 07/16/2020

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