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Research at the Clinical Center

Published Clinical Research Conducted at the Clinical Center

The NIH Clinical Center is the world’s largest hospital entirely devoted to clinical research. It is a national resource that makes it possible to rapidly translate scientific observations and laboratory discoveries into new approaches for diagnosing, treating, and preventing disease.

Over 1,600 clinical research studies are conducted at the NIH Clinical Center, including those focused on cancer, infectious diseases, blood disorders, heart disease, lung disease, alcoholism and drug abuse.

Here is a sample of abstracts from the clinical research conducted at the NIH Clinical Center and published in a peer reviewed medical journal this year. Links to the full text and video formats are provided if available.


arm with blood pressure cuff and tubes

Increased serum pro-B-type natriuretic peptide in hematopoietic progenitor cell donors stimulated with G-CSF

Published in: Journal of Clinical Apheresis (March 2022)

In a case series of 18 healthy stem cell donors who received a common stimulation regimen, a protein that is commonly associated with heart failure increased transiently in their blood. The long-term impact on donor’s health is pending evaluation.

Read the article.

Two microbiologists with protective face masks looking at Petri dish in laboratory

IDSA guidance and ESCMID guidelines: complementary approaches toward a care standard for MDR Gram-negative infections

Published in: Clinical Microbiology and Infection (February 2022)

As antibiotic resistant bacteria spread globally, there is an increasing need for experts to provide recommendations on how to treat these infections. In this editorial, the strengths and weaknesses of the recommendations by the Infectious Diseases Society of America and European Society of Clinical Microbiology and Infectious Diseases are highlighted.

Read the article.

Breat cancers are immunogenic

Breast Cancers Are Immunogenic: Immunologic Analyses and a Phase II Pilot Clinical Trial Using Mutation-Reactive Autologous Lymphocytes

Published in: PubMed (February 2022)

In a pilot clinical trial, 28 of 42 patients with metastatic breast cancer naturally raised immune lymphocytes targeting the expressed products of their cancer mutations. Three of six patients treated with these lymphocytes exhibited cancer regression. This experimental treatment may be an option for patients with metastatic breast cancer.

Read the article.

Cross Cultural Adaptation

Cross Cultural Adaptation and Cognitive Testing of a Psycho-Social-Spiritual Healing Measure, the NIH Healing Experiences in All Life Stressors-NIH-HEALS

Published in: Global Advances in Health and Medicine  (January 2022)

The face and content validity of the NIH Healing Experiences in All Life Stressors (NIH-HEALS) was assessed in a population of cancer patients in Uganda. Some minor changes are recommended to culturally adapt this survey for the local context.

Read the article.

Nasal swab

Adolescents, Parents, and Covid-19 Vaccination - Who Should Decide?

Published in: The New England Journal of Medicine (January 2022)

Researchers review various perspectives, barriers and approaches regarding the age for informed consent and medical decision-making for COVID-19 vaccination among adolescents aged 12-17. Allowing adolescents to independently consent to the vaccination could increase vaccine uptake in this population.

Read the article.

NOTE: PDF documents require the free Adobe Reader.

This page last updated on 05/02/2022

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