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Research at the Clinical Center

Published Clinical Research Conducted at the Clinical Center

The NIH Clinical Center is the world’s largest hospital entirely devoted to clinical research. It is a national resource that makes it possible to rapidly translate scientific observations and laboratory discoveries into new approaches for diagnosing, treating, and preventing disease.

Over 1,600 clinical research studies are conducted at the NIH Clinical Center, including those focused on cancer, infectious diseases, blood disorders, heart disease, lung disease, alcoholism and drug abuse.

Here is a sample of abstracts from the clinical research conducted at the NIH Clinical Center and published in a peer reviewed medical journal this year. Links to the full text and video formats are provided if available.


Illustration of Covid cell

The Impact of Corticosteroids on Secondary Infection and Mortality in Critically Ill COVID-19 Patients

Published in: Journal of Intensive Care Medicine (July 2021)

Corticosteroids, an anti-inflammatory therapy, do not increase the risk of secondary infection in patients who are critically-ill with COVID-19. Researchers conclude Corticosteroids are safe, effective and a lifesaving therapy option in patients who are critically ill with COVID-19.

Read the article.

Illustration of lesions

Improving Weakly Supervised Lesion Segmentation using Multi-Task Learning

Published in: Proceedings of Machine Learning Research (May 2021)

Multi-task learning was used to improve the quality of skin and cancer lesion segmentation, while significantly reducing the training time. This research may benefit cancer patients because lesion size, obtained here by segmentation, is an important indicator of treatment response.

Read the article.

Medical scan of kidney

Genetic and Epidemiologic Analyses of an Outbreak of Pneumocystis jirovecii Pneumonia among Kidney Transplant Recipients in the United States

Published in: Clinical Infectious Diseases (May 2021)

An outbreak of Pneumocystis pneumonia (PCP) in the Yale kidney transplant clinics promoted a collaborative investigation which identified an interhuman transmission of multiple Pneumocystis strains and highlights the critical role of next-generation sequencing in better understanding the epidemiology of PCP outbreaks.

Read the article.

Mother and child

Putting Anti-Racism into Practice as a Healthcare Ethics Consultant

Published in: The American Journal of Bioethics (May 2021)

The events of this past year and the evidence they reveal about the ongoing impact of racism on the health of Black Americans and other minorities moves us to consider the role of healthcare ethicists in addressing this injustice within healthcare organizations.

Read the article.


Hereditary Alpha-Tryptasemia (HαT): a Commonly Inherited Modifier of Anaphylaxis

Published in: Current Allergy and Asthma Reports (May 2021)

Hereditary Alpha-Tryptasemia is a dominant genetic trait and a common cause for elevated basal serum tryptase in Western populations. HαT is now established as a risk factor for severe anaphylaxis among individuals with venom allergy- particularly in the context of mast cell–associated disorders.

Read the article.

minor receiving vaccine

Enrolling Minors in COVID-19 Vaccine Trials

Published in: Pediatrics (March 2021)

A systemic approach is proposed for enrolling minors in COVID-19 vaccine trials. Beginning with older healthy adolescents, minors should be enrolled after safety is established, but before efficacy is proven in adults.

Read the article.


Effects of Chloroquine or Hydroxychloroquine Treatment on Non‐SARS‐CoV2 Viral Infections: A Systematic Review of Clinical Studies

Published in: Reviews in Medical Virology (March 2021)

A systematic review of prior clinical studies comparing the effects of chloroquine or hydroxychloroquine to a control for the treatment of non‐SARS‐CoV2 infection shows no support for their use as antiviral treatments for SARS‐CoV2.

Read the article.

COVID-19 virus

COVID-19 Antibody Screening with SARS-CoV-2 Red Cell Kodecytes Using Routine Serologic Diagnostic Platforms

Published in: Transfusion (February 2021)

Red blood cells modified with Kode Technology to resemble the COVID-19 virus can be used with routine blood antibody screening equipment to detect antibodies to COVID-19.

Read the article.

NOTE: PDF documents require the free Adobe Reader.

This page last updated on 09/10/2021

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