Here is a sample of abstracts from the clinical research conducted at the NIH Clinical Center and published in a peer reviewed medical journal in 2019. Links to the full text and video formats are provided if available.
Enhancing the Cancer Caregiving Experience: Building Resilience Through Role Adjustment and Mutuality
Published in: European Journal of Oncology Nursing (December 2019)
Coping with role adjustment and sustaining interpersonal connection, from cancer diagnosis through survivorship, is essential for a resilient relationship between a cancer patient and their primary family caregiver.
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Mobilization and Collection of Cells in the Hematologic Compartment for Cellular Therapies: Stem Cell Collection with G-CSF/Plerixafor, Collecting Lymphocytes/Monocytes
Published in: Seminars in Hematology (October 2019)
Mobilization and collection of donor or patient hematopoietic progenitor cells, lymphocytes, or monocytes are essential first steps in cellular therapy. G-CSF and plerixafor have improved collection yields, and apheresis technology provides a basis for optimizing collections.
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Simulation Training in the ICU
Published in: Chest (September 2019)
Since ICU patients require invasive procedures and efficient interprofessional team performance in a high-stakes environment, simulation is well-suited to safely train skills needed for ICU practice. This review evaluates the high-quality data regarding simulation in critical care training.
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Evaluating the Risks of Public Health Programs: Rational Antibiotic Use and Antimicrobial Resistance
Published in: Bioethics (September 2019)
An ethical framework is proposed for evaluating public health programs that compromise the best clinical interests of present patients. This framework is applied and examined with programs that withhold or delay antibiotics in order to curb antimicrobial resistance.
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Effect of Cryopreservation on Autologous Chimeric Antigen Receptor T-Cell Characteristics
Published in: Molecular Therapy (July 2019)
At the NIH Center for Cellular Engineering, genetically modified immune cells that are frozen as soon as they are made and infused in patients immediately after being thawed are as clinically effective as genetically modified immune cells that are freshly made.
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Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: A One-Month Inpatient Randomized Controlled Trial of Ad Libitum Food Intake
Published in: Cell Metabolism (July 2019)
Researchers conducted the first randomized controlled trial to confirm that ultra-processed diets cause excess calorie intake and weight gain.
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Immunology and Immunotherapy in Critical Care: An Overview
Published in: AACN Advanced Critical Care (June 2019)
The article provides a detailed description of how the human immune system works and how the different types of cancer immunotherapies interact with the immune system to produce benefits and side effects. This information will help guide the care of patients receiving immunotherapies.
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Understanding Long-Term Effects of Ebola Virus Disease
Published in: Nature Medicine (May 2019)
After year one of a five-year study, survivors of Ebola virus disease in West Africa had more memory loss, uveitis, and neurological, muscle, joint, chest, and abdominal abnormalities than the uninfected control group.
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Combined Locoregional-Immunotherapy for Liver Cancer
Published in: Journal of Hepatology (May 2019)
Interventional radiology and cancer immunology experts from the NIH Clinical Center and the NCI Center for Cancer Research pioneered the use of immune checkpoint blockade and minimally-invasive image guided procedures in patients with liver cancer and discuss outstanding issues to optimizing this multi-disciplinary treatment strategy.
Read the article.
The Value of Engaging the Public in CHATing About Healthcare Priorities: A Response to Recent Commentaries
Published in: International Journal of Health Policy and Management (April 2019)
Responding to questions and comments on their study, Swiss-CHAT: Citizens Discuss Priorities for Swiss Health Insurance Coverage, the authors emphasize which citizens discussed complex issues and the validation of public participation in healthcare decisions.
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Immunotherapy and the Interventional Oncologist: Challenges and Opportunities—A Society of Interventional Oncology White Paper
Published in: Radiology (April 2019)
An expert panel of immuno- and interventional oncologists discuss current and potential opportunities for immuno-oncology to be combined with interventional oncology to deliver improved or new benefits in the treatment of patients with cancer.
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Constructing Identities: The Implications of DTC Ancestry Testing for Tribal Communities Gastric Cancer Syndrome
Published in: Genetics in Medicine (March 2019)
Issues are created for Native American communities when genetic ancestry companies promote the ability to determine Native American heritage and incorporate concepts of Native American race, ethnicity and group membership in marketing.
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On Being the “Right” Kind of Chronic Pain Patient
Published in: Narrative Inquiry in Bioethics (March 2019)
The challenges experienced by 12 Americans living with chronic pain during an opioid epidemic and the sharp health disparities in chronic pain management are explored.
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Euthanasia and Assisted Suicide of Persons With Psychiatric Disorders: the Challenge of Personality Disorders
Published in: Psychological Medicine (March 2019)
Researchers discuss the evaluation process and challenges of Dutch patients with personality disorders who received euthanasia or assisted suicide based on thier psychiatric disorder.
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Epidemiology of Shock in Contemporary Cardiac Intensive Care Units
Published in: Circulation: Cardiovascular Quality and Outcomes (March 2019)
A multicenter evaluation of patients in North American cardiac intensive care units confirm a shift in the predominant underlying cause of cardiogenic shock - the most severe form of acute heart failure - to cardiovascular conditions other than acute heart attack.
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The Phylogeny of 48 Alleles, Experimentally Verified at 21 kb, and Its Application to Clinical Allele Detection
Published in: Journal of Translational Medicine (February 2019)
Researchers pioneered the discovery and description of 4,243 different forms of a gene which, in this large number, can improve the accuracy of identifying the two forms of the gene present in every person and to improve precision diagnostics in patients.
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External Validation of Difficult-to-Treat Resistance Prevalence and Mortality Risk in Gram-Negative Bloodstream Infection Using Electronic Health Record Data from 140 US Hospitals
Published in: Open Forum Infectious Diseases (February 2019)
Electronic health records confirmed a previous finding from administrative datasets that patients with gram-negative bloodstream infections that are resistant to all first-line antibiotics are associated with higher mortality risk compared to those where one or more first-line antibiotics are active.
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Establishing a Center of Excellence for Hereditary Diffuse Gastric Cancer Syndrome
Published in: Journal of Surgical Oncology (January 2019)
A new program at the NIH Clinical Center for patients with hereditary gastric cancer syndromes incorporates comprehensive high-quality medical care and clinical and basic science research in a highly integrated, multidisciplinary setting.
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Read more articles about research at the NIH Clinical Center in 2019.