Dr. Dima A. Hammoud is senior investigator in Radiology and Imaging Sciences (NIHCC) and deputy director in the Center for Infectious Disease Imaging, a joint initiative between Radiology and Imaging Sciences and the National Institute of Allergy and Infectious Diseases. She is also a neuroradiologist at Radiology and Imaging Sciences since 2006.
Dr. Hammoud attended college at the American University of Beirut in Lebanon, where she earned a bachelor's degree in biology and an MD degree. After completing a residency in diagnostic radiology at the American University of Beirut-Medical Center, she joined the division of neuroradiology at the Johns Hopkins Hospital as a fellow. After completion of her fellowships, she joined the neuroradiology faculty at Johns Hopkins as assistant professor.
In 2006, she joined the neuroradiology faculty at NIH.
Dr Hammoud is board-certified in diagnostic imaging by the American Board of Radiology, and has completed fellowships in neuroradiology and positron emission tomography (PET) imaging.
She is a member of the Society of Nuclear Medicine and Molecular Imaging and Radiological Society of North America. She currently serves as a member of the Molecular Imaging Abstract Review Subcommittee of the Scientific Program Committee and Education Exhibits Committee at RSNA and has previously served as a Board member of the Center for Molecular Imaging Innovation and Translation Program Task Force at SNMMI.
Dr. Hammoud's research interests include the development of preclinical, translational and clinical molecular imaging applications to improve the understanding of the pathophysiology of infection, and to provide reliable pathogen specific imaging biomarkers of infectious diseases.
Research in her laboratory focuses on further understanding the pathophysiology of cognitive dysfunction and immune activation in the setting of HIV infection using non-invasive molecular imaging techniques, mainly PET. Current projects include PET imaging of glucose metabolism and neurotransmitter systems in HIV infected patients.
She is also an expert in imaging high-consequence viral infections such as Ebola, Nipah and Lassa viruses, in collaboration with the Integrated Research Facility (NIAID), a BSL-4 biomedical research facility based in Fort Detrick, Maryland. Another major interest of the Hammoud lab is the development and validation of pathogen-specific fungal PET imaging ligands, in animal models and eventually in patients.
See her Intramural Research Program bio page.
Shah S, Sinharay S, Matsuda K, Schreiber-Stainthorp W, Muthusamy S, Lee D, Wakim P, Hirsch V, Nath A, Di Mascio M, Hammoud DA. Potential Mechanism for HIV-Associated Depression: Upregulation of Serotonin Transporters in SIV-Infected Macaques Detected by 11C-DASB PET. Front. Psychiatry, 23 May 2019 |https://doi.org/10.3389/fpsyt.2019.00362.
Hammoud DA, Sinharay S, Shah S, Schreiber-Stainthorp W, Maric D, Muthusamy S, Lee DE, Lee CA, Basuli F, Reid WC, Wakim P, Matsuda K, Hirsch V, Nath A, Di Mascio M. Neuroinflammatory Changes in Relation to Cerebrospinal Fluid Viral Load in Simian Immunodeficiency Virus Encephalitis. MBio. 2019 May 28;10(3). pii: e00970-19. doi: 10.1128/mBio.00970-19.
Sinharay S, Hammoud DA. Brain PET Imaging: Value for Understanding the Pathophysiology of HIV-associated Neurocognitive Disorder (HAND). Curr HIV/AIDS Rep. 2019 Feb 18.
Hammoud DA, Boulougoura A, Papadakis GZ, Wang J, Dodd LE, Rupert A, Higgins J, Gregg Roby G, Metzger D, Laidlaw E, Mican JM, Lage S, Wong C, Lisco A, Manion M, Sheikh V, Millo C, Sereti I. Increased metabolic activity on 18F-Fluorodeoxyglucose PET/CT in HIV-associated immune reconstitution syndrome. Clinical Infectious Diseases. 2019 Jan 7;68(2):229-238.
Riggle BA, Sinharay S, Schreiber-Stainthorp W, Munasinghe JP, Maric D, Prchalova E, Slusher BS, Powell JD, Miller LH, Pierce SK, Hammoud DA. MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice. PNAS, Proc Natl Acad Sci U S A. 2018 Dec 4. pii: 201812909.
Hammoud DA, Sinharay S, Steinbach S, Wakim PG, Geannopoulos K, Traino K, Dey AK, Tramont E, Rapoport SI, Snow J, Mehta NN, Smith BR, Nath A. Global and regional brain hypometabolism on FDG PET in treated HIV infected individuals. Neurology, 2018, Oct 23;91(17):e1591-e1601.
Mee TC, Aepfelbacher J, Krakora R, Chairez C, Kvaratskhelia N, Smith B, Sandfort V, Hadigan C, Morse C, Hammoud DA. Carotid magnetic resonance imaging in persons living with HIV and 10-year atherosclerotic cardiovascular disease risk score. Antivir Ther. 2018 Aug 8.
Schreiber-Stainthorp W, Sinharay S, Srinivasula S, Shah S, Wang J, Dodd L, Lane HC, Di Mascio M, Hammoud DA. Brain 18F-FDG PET of SIV-infected macaques after treatment interruption or initiation. J Neuroinflammation. 2018 Jul 14;15(1):207.
Casas R, Muthusamy S, Wakim PG, Sinharay S, Lentz MR, Reid WC, Hammoud DA. MR brain volumetric measurements are predictive of neurobehavioral impairment in the HIV-1 transgenic rat. Neuroimage Clinical. 2017 Nov 21;17:659-666.
Sinharay S, Lee D, Shah S, Muthusamy S, Papadakis GZ, Zhang X, Maric D, Reid WC, Hammoud DA. Cross-sectional and longitudinal small animal PET shows pre and post-synaptic striatal dopaminergic deficits in an animal model of HIV. Nucl Med Biol. 2017 Dec;55:27-33.
Hammoud DA. Molecular Imaging of Inflammation: Current Status. Journal of Nuclear Medicine. 2016 Aug;57(8):1161-5.
- Intramural Targeted Anti-COVID-19 (ITAC) Award: Imaging effect of S-protein mediated ACE2 downregulation on lung injury. Role: Principal Investigator, 2020-2023
- Office of AIDS Research strategic fund: PET Imaging of HIV in animal models using radiolabeled single domain antibody against CD4-binding site of Gp120. Role: Principal Investigator, 2020
- Office of AIDS Research innovation fund: PET Imaging of Presynaptic Nigrostriatal Dopaminergic Function in Optimally Treated HIV+ Patients. Role: Principal Investigator, 2017
- National Institute of Allergy and Infectious Diseases Merit award, 2015
- Bench to Bedside award: Treatment of Anti-NMDA receptor encephalitis. Role: Associate Investigator (PI: Avindra Nath), 2012-2013
- Bench to Bedside award: Imaging bacterial infection in immunocompromised patients. Role: Principal Investigator, 2011-2012
- Dana Foundation Program in Brain and Immuno-imaging grant, Topic: Imaging Inflammation in AIDS Dementia: PET with [11C]Arachidonic Acid Role: Principal Investigator, July 1, 2005 – July 1, 2009
NOTE: PDF documents require the free Adobe Reader.
This page last updated on 06/13/2022