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Dr. Bradford Wood directs a multi-disciplinary team (NIH Center for Interventional Oncology) that develops and translates devices, software, and navigation approaches for cancer patients via novel local and regional minimally-invasive image-guided therapies.
Dr. Wood earned both undergraduate and graduate degrees from The University of Virginia, did Internal Medicine internship, followed by Residency in Diagnostic Radiology at Georgetown University, where he was Chief Resident. He then went on to do double fellowships at Harvard / Massachusetts General Hospital in Abdominal Imaging and Intervention and Vascular and Interventional Radiology, and stayed on staff at MGH after training.
Dr. Wood came to the NIH in 1998. He is the Chief of Interventional Radiology and the founding Director of the NIH Center for Interventional Oncology, which has been a partnership between National Cancer Institute and the NIH Clinical Center for well over a decade. He holds appointments in Radiology & Imaging Sciences in the Clinical Center, as well as the National Cancer Institute and the Urological Oncology Branch in the Center for Cancer Research. He is the co-Program Director for the NIBIB Clinical Translational Research Fellowship Program and a member of the NCI CCR Liver Cancer Program. He is a Fellow of the Society for Interventional Radiology and was Acting Co-Director of Radiology from 2006 to 2008.
The Center for Interventional Oncology translates technologies and paradigms for first-in-human treatments for cancer and cultivates interventional radiology applications within a muliti-disciplinary framework, to apply biomedical engineering to meet real-life unmet clinical needs.
His team’s achievements include helping to pioneer several technologies from concept to bench to patient, and was “first- -in-human” for the following device/drug combinations: prostate cancer MRI/TRUS fusion biopsy and ablation, image-able iodinated drug eluting beads for chemoembolization of liver tumors, heat deployed chemotherapy combined with thermal ablation for liver cancer, “medical GPS” electromagnetic (EM) tracking for fusion of ultrasound to CT, MR, and PET, and fusion for needle-based procedures like biopsy and thermal ablation, and kidney and adrenal tumor ablation. The NIH team has performed over 40,000 needle procedures in over 2,500 patients with tracking and fusion technology, which has become a standard of care worldwide. The NCI liver cancer team was also the first to combine check point immunotherapies with local and regional image-guided thermal ablation or chemo-embolization for liver and biliary tract cancers in clinical trials.
His research relies upon multi-disciplinary team science within multiple institutes and international public-private partnerships. He has received the NIH Directors Award, the Clinical Center Director’s Award, the NCI Director’s Award of Merit, NCI Research Highlights Award, and the NIH Clinical Center CEO Award.
Dr Wood has mentored hundreds of students, fellows, physicians, nurses, and scientists. He has published more than 10 issued patents, books on radiology and interventional urology, and co-authored more than 450 peer-reviewed manuscripts - (JAMA, Lancet, Science, Nature Reviews, Cancer, Blood, Chest, Transplantation, JAMA Oncology, Hepatology, CA: A Cancer Journal for Clinicians, Journal of Clinical Oncology, Medical Physics, Radiology, and Clinical Cancer Research. Teamwork breeds team success.
Siddiqui MM, Rais-Bahrami S, Turkbey B, George A, Rothwax J, Shakir N, Okoro C, Raskolnikov D, Parnes HL, Linehan WM, Merino MJ, Simon RM, Choyke PL, Wood BJ, Pinto PA: Comparison of MR/Ultrasound Fusion-Guided Biopsy With Ultrasound-Guided Biopsy for the Diagnosis of Prostate Cancer. JAMA 2015, Jan 27;313(4):390-397
Levy EB, Krishnasamy VP, Lewis AL, Willis S, Macfarlane C, Anderson V, van der Bom IM, Radaelli A, Dreher MR, Sharma KV, Negussie A, Mikhail AS, Geschwind JF, Wood BJ: First Human Experience with Directly Image-able Iodinated Embolization Microbeads. Cardiovasc Intervent Radiol. 2016 Aug;39(8):1177-86
Greten TF, Mauda-Havakuk M, Heinrich B, Korangy F, Wood BJ: Combined locoregional-immunotherapy for liver cancer. J Hepatol. 2019 Feb 6 [Epub ahead of print]
Xie C, Duffy AG, Mabry-Hrones D, Wood B, Levy E, Krishnasamy V, Khan J, Wei JS, Agdashian D, Tyagi M, Gangalapudi V, Fioravanti S, Walker M, Anderson V, Venzon D, Figg WD, Sandhu M, Kleiner DE, Morelli MP, Floudas CS, Brar G, Steinberg SM, Korangy F, Greten TF: Tremelimumab in combination with microwave ablation in patients with refractory biliary tract cancer. Hepatology. 2018 Dec 22 [Epub ahead of print]
Gaur S, Lay N, Harmon SA, Doddakashi S, Mehralivand S, Argun B, Barrett T, Bednarova S, Girometti R, Karaarslan E, Kural AR, Oto A, Purysko AS, Antic T, Magi-Galluzzi C, Saglican Y, Sioletic S, Warren AY, Bittencourt L, Fütterer JJ, Gupta RT, Kabakus I, Law YM, Margolis DJ, Shebel H, Westphalen AC, Wood BJ, Pinto PA, Shih JH, Choyke PL, Summers RM, Turkbey B: Can computer-aided diagnosis assist in the identification of prostate cancer on prostate MRI? a multi-center, multi-reader investigation. Oncotarget. 2018 Sep 18;9(73):33804-33817
Bloom JB, Gold SA, Hale GR, Rayn KN, Sabarwal VK, Bakhutashvili I, Valera V, Turkbey B, Pinto PA, Wood BJ (2018). "Super-active surveillance": MRI ultrasound fusion biopsy and ablation for less invasive management of prostate cancer. Gland Surg 7, 166-187
Lewis AL, Dreher MR, O'Byrne V, Grey D, Caine M, Dunn A, Tang Y, Hall B, Fowers KD, Johnson CG, Sharma KV, Wood BJ: DC BeadM1™: towards an optimal transcatheter hepatic tumour therapy. J Mater Sci Mater Med. 2016 Jan;27(1):13
Turkbey B, Brown AM, Sankineni S, Wood BJ, Pinto PA, Choyke PL: Multiparametric prostate magnetic resonance imaging in the evaluation of prostate cancer. CA Cancer J Clin. 2015
Wood BJ, Poon RT, Locklin J, Dreher MR, Ng KK, Eugeni M, Seidel G, Dromi S, Neeman Z, Kolf M, Black CDV, Prabhakar R, Libutti SK: A Phase I Study of Heat Deployed Liposomal Doxorubicin during Radiofrequency Ablation for Hepatic Malignancies. J Vasc Interv Radiol 2012
Amalou H, Wood BJ: Biopsy and personalized medicine. Nature Rev Gastroenterol Hepatol. 2012 Nov;9(11):683
Pinto PA, Chung PH, Rastinehad AR, Baccala AA Jr, Kruecker J, Benjamin CJ, Xu S, Yan P, Kadoury S, Chua C, Locklin JK, Turkbey B, Shih JH, Gates SP, Buckner C, Bratslavsky G, Linehan WM, Glossop ND, Choyke PL, Wood BJ: Magnetic resonance imaging/ultrasound fusion guided prostate biopsy improves cancer detection following transrectal ultrasound biopsy and correlates with multiparametric magnetic resonance imaging. J Urol. 2011 Oct;186(4):1281-5
Venkatesan AM, Kadoury S, Abi-Jaoudeh N, Levy EB, Maass-Moreno R, Krücker J, Dalal S, Xu S, Glossop N, Wood BJ: Real-time FDG PET Guidance during Biopsies and Radiofrequency Ablation Using Multimodality Fusion with Electromagnetic Navigation. Radiology. 2011 Sep;260(3):848-56
Krücker J, Xu S, Venkatesan A, Locklin J, Amalou H, Glossop N, Wood BJ: Clinical Utility of Real-Time Fusion Guidance for Biopsy and Ablation. J Vasc Interv Radiol 2011;22:515-24
Sharma KV, Dreher MR, Tang Y, Pritchard W, Chiesa OA, Karanian J, Perogoy J, Orandi B, Woods D, Donahue D, Esparza J, Jones G, Willis SL, Lewis AL, Wood BJ: Development of "imageable" beads for transcatheter embolotherapy., J Vasc Interv Radiol 2010;21:865-76
Dromi SA, Herby S, Walsh M, Dreher M, Xie J, Fry T, Wood BJ: Radiofrequency Ablation Induces Antigen Presenting Cell Infiltration and Amplification of Weak Tumor-Induced Immunity, Radiology 2009; 251:58-66
Xu S, Kruecker J, Guion P, Glossop N, Neeman Z, Choyke P, Singh AK, Wood BJ: Closed-loop control in fused MR-TRUS image-guided prostate biopsy. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 2007;10:128-35
Krücker J, Xu S, Glossop N, Viswanathan A, Borgert J, Schulz H, Wood BJ: Electromagnetic tracking for thermal ablation and biopsy guidance: clinical evaluation of spatial accuracy. J Vasc Interv Radiol 2007;18:1141-1150
Dromi S, Frenkel V, Luk A, Traughber B, Angstadt M, Bur M, Poff J, Xie J, Libutti SK, Li KCP, Wood BJ: Pulsed-high intensity focused ultrasound and low temperature sensitive liposomes for enhanced targeted drug delivery and anti-tumor effect. Clin Cancer Res 2007;13:2722-2727
Wood BJ, Ramkaransingh JR, Fojo T, Walther MM, Libutti SK: Percutaneous Tumor Ablation with Radiofrequency. Cancer 2002; 94:443-451
Pacek K, Fojo T, Goldstein DS, Eisenhofer G, Walther M, Linehan WM, Bachenheimer L, Abraham J, Wood BJ: Radiofrequency Ablation (RFA): A novel approach for the treatment of metastatic pheochromocytoma. J Natl Cancer Inst 2001;93:648-649
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This page last updated on 03/14/2019