Irina Maric, MD, MS

MD, University of Belgrade
MSci, University of Belgrade

Dr. Maric is a Senior Research Physician and Attending Staff Hematopathologist in the Hematology Service in the Department of Laboratory Medicine at the NIH Clinical Center. Dr. Maric is also a Core Faculty of the NIH Hematopathology Fellowship Program.

Dr. Maric received residency training in Anatomic Pathology and Clinical Pathology at the George Washington University School of Medicine in Washington, D.C., fellowship training in Surgical Pathology at the George Washington University School of Medicine in Washington, D.C. and fellowship training in Hematopathology at the NCI Laboratory of Pathology. She is board certified in Anatomic Pathology and Clinical Pathology specialties and Hematology subspecialty.

Dr. Maric has been a practicing hematopathologist in the Department of Laboratory Medicine since 2003. She has a special research interest in rare chronic myeloproliferative diseases, particularly chronic eosinophilic leukemia and systemic mastocytosis. She has published over 150 peer-reviewed papers and four book chapters. She is a member of several Pathology and Hematology professional societies. Dr. Maric is a recipient of multiple NIH awards. She is a reviewer for numerous scientific journals in the fields of Pathology and Hematology and is an editorial board member of the Frontiers in Medicine journal.

• Clinical Center Director Award, NIH, 2024
• Special Act Award, Department of Laboratory Medicine, Clinical Center, NIH, 2022
• Clinical Center Director Award, NIH, 2020
• Special Act Award, Department of Laboratory Medicine, Clinical Center, NIH, 2020
• NIAID Merit Award, National Institute of Allergy and Infectious Diseases, NIH, 2017
• Best Mentor Award, Clinical Center Summer Internship Program, NIH, 2017
• Distinguished Clinical Teacher Award Nominee, Clinical Center, NIH, 2015
• Clinical Center Director Award, NIH, 2013
• Society for Hematopathology Award, United States and Canadian Academy of Pathology, 2004
• Harry C. Miller Teaching Excellence Award, Department of Urology, The George Washington University School of Medicine, 2002
• Frank N. Miller Award for Excellence, Department of Pathology, The George Washington University School of Medicine, 2001-2002

Trindade CJ, Sun X, Maric D, Sharma S, Komarow HD, Hourigan CS, Klion A, Maric I. Flow Cytometric Immunophenotypic Differentiation Patterns of Bone Marrow Eosinophilopoiesis. Cytometry B Clin Cytom. 106:370-382, 2024.

Aldama LND, Karlins E, Sun X, Veltri D, Komarow HD, Maric I, Metcalfe DD, Carter MC. Prevalence and Impact of the KIT M541L Variant in Patients with Mastocytosis. Oncotarget. 15:521-531, 2024.McMurray JC, Pacheco CS, Schornack BJ, Sun X, Brunader JA, Scott AE, Ariza JS, Kou CJ, Costantino RC, Pittman LM, Adams KE, Waters AM, Pryor EM, Lyons JJ, Metcalfe DD, Maric I, Boggs NA. Standardized Indolent Systemic Mastocytosis Evaluations Across a Health Care System: Implications for Screening Accuracy. Blood. 144:408-419, 2024.

Boggs NA, Sun X, Lyons JJ, McMurray JC, Rose DM, Pryor EM, Metcalfe DD, Maric I. Challenges in Applying Diagnostic Criteria for Systemic Mastocytosis. Blood Adv. 7:3150-3154, 2023.

Pongdee T, Berry A, Wetzler L, Sun X, Thumm L, Yoon P, Kuang FL, Makiya M, Constantine G, Khoury P, Rheinbay E, Lane AA, Maric I, Klion AD. False-Negative Testing for FIP1L1::PDGFRA by Fluorescence in situ Hybridization Is a Frequent Cause of Diagnostic Delay. Acta Haematol. 146:316-321, 2023.

Maric I and Sun X. Advances in Diagnosis of Mastocytosis and Hypereosinophilic Syndrome. Sem Hematol. 56:22-29, 2019.

Kuang FL, Legrand F, Makiya M, Ware J, Wetzler L, Brown T, Magee T, Piligian B, Yoon P, Ellis JH, Sun X, Panch SR, Powers A, Alao H, Kumar S, Quezado M, Yan L, Lee N, Kolbeck R, Newbold P, Goldman M, Fay MP, Khoury P, Maric I, Klion AD. Benralizumab for PDGFRA-Negative Hypereosinophilic Syndrome. N Engl J Med. 380:1336-1346, 2019.

Carter MC, Bai Y, Ruiz-Esteves KN, Scott LM, Cantave D, Bolan H, Eisch R, Sun X, Hahn J, Maric I, Metcalfe DD. Detection of KIT D816V in peripheral blood of children with manifestations of cutaneous mastocytosis suggests systemic disease. Br J Haematol. 183:775-782, 2018.

Brudno JN, Maric I, Hartman SD, Rose JJ, Wang M, Lam N, Stetler-Stevenson M, Salem D, Yuan C, Pavletic S, Kanakry JA, Ali SA, Mikkilineni L, Feldman SA, Stroncek DF, Hansen BG, Lawrence J, Patel R, Hakim F, Gress RE, Kochenderfer JN. T Cells Genetically Modified to Express an Anti-B-Cell Maturation Antigen Chimeric Antigen Receptor Cause Remissions of Poor-Prognosis Relapsed Multiple Myeloma. J Clin Oncol. 36:2267-2280, 2018.

Carter MC, Desai A, Komarow HD, Bai Y, Clayton ST, Clark AS, Ruiz-Esteves KN, Long LM, Cantave D, Wilson TM, Scott LM, Simakova O, Jung MY, Hahn J, Maric I, Metcalfe DD. A distinct biomolecular profile identifies monoclonal mast cell disorders in patients with idiopathic anaphylaxis. J Allergy Clin Immunol. 141:180-188, 2018.

Panch SR, Bozik ME, Brown T, Makiya M, Prussin C, Archibald DG, Hebrank GT, Sullivan M, Sun X, Wetzler L, Ware J, Fay MP, Dunbar CE, Dworetzky SI, Khoury P, Maric I, Klion AD. Dexpramipexole as an oral steroid-sparing agent in hypereosinophilic syndromes. Blood. 132:501-509, 2018.

Xie Y, Pittaluga S, Price S, Raffeld M, Hahn J, Jaffe ES, Rao VK, Maric I. Bone marrow findings in autoimmune lymphoproliferative syndrome with germline FAS mutation. Haematologica. 102:364-372, 2017.

Korde N, Zhang Y, Loeliger K, Poon A, Simakova O, Zingone A, Costello R, Childs R, Noel P, Silver S, Kwok M, Mo C, Young N, Landgren O, Sloand E, Maric I. Monoclonal gammopathy-associated pure red cell aplasia. Br J Haematol. 173:876-883, 2016.

Maric I. CD30-targeting drugs: cure for mastocytosis? Blood 126:2771-2773, 2015.