Skip to main content

Patient Recruitment

Best Noninvasive Predictor of Renal Function in Assessing Adult Sickle Nephropathy

Sickle Cell Patients Needed for Kidney Function Study

close-up medical illustration of sickle cells

sickle cell and kidney flowchart

Kidney complications can be significant problem in patients with sickle cell. Doctors at the National Institutes of Health (NIH) seek patients with sickle cell disease to evaluate the best noninvasive predictor of renal function. The study will measure kidney function with an iothalamate test, the "gold standard" measure of kidney function, and see how it relates to the following:

✓ Cystatin-C (a protein that is produced by the cells in your body)
✓ Urinary protein content
✓ Kidney MRI (to assess renal anatomy as well as blood flow and iron accumulation)

Who Can Particpate?

  • Patients 18 and older with sickle cell anemia (including HbSS, HbS-β0 thalassemia)

Study Design

  • All volunteers will undergo screening labs to ensure they meet eligibility criteria
  • Study volunteers will be compensated for their participation

The NIH Clinical Center is America's Research Hospital and is located in Bethesda, Maryland, on the Metro Red line (Medical Center stop).

Contact information:
Office of Patient Recruitment
TTY for the deaf or hard of hearing: 1-866-411-1010
Se habla español

Or go online:
Refer to study # 19-H-0100

Department of Health and Human Services
National Institutes of Health Clinical Center (CC)
National Heart, Lung and Blood Institute (NHLBI)

NOTE: PDF documents require the free Adobe Reader.

This page last updated on 10/22/2021

You are now leaving the NIH Clinical Center website.

This external link is provided for your convenience to offer additional information. The NIH Clinical Center is not responsible for the availability, content or accuracy of this external site.

The NIH Clinical Center does not endorse, authorize or guarantee the sponsors, information, products or services described or offered at this external site. You will be subject to the destination site’s privacy policy if you follow this link.

More information about the NIH Clinical Center Privacy and Disclaimer policy is available at