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Patient Recruitment

National Cancer Institute Researchers Seeking Patients Diagnosed with Hepatocellular Carcinoma

Are You Diagnosed With Hepatocellular Carcinoma?

medical illustration of a human liver

Researchers at the National Institutes of Health (NIH) in Bethesda, Maryland are investigating if nivolumab given in combination with tadalafil and vancomycin may help liver tumors to shrink. Nivolumab is an immune therapy treatment agent that helps the immune system effectively fight cancer. Tadalafil is considered to be a cancer treatment sensitizer and vancomycin is an antibiotic that alters the gut bacteria leading to a liver specific immune response by the patient. Current treatment options for patients with liver cancers, including hepatocellular carcinoma (HCC) and advanced liver cancers are limited. This Research study may provide answers for a new treatment that may help patients with hepatocellular carcinoma or metastases to the liver from colorectal or pancreatic cancer for which standard treatment has not been of benefit.


  • Physical exam and blood testing
  • Scan of the chest, abdomen, and pelvis
  • Participants will receive the study drugs in 4-week cycles
  • There is no cost for study related medication, tests or procedures


  • Must be 18 years or older
  • Diagnosed with Hepatocellular Carcinoma
  • No signs of liver failure

The NIH Clinical Center, America's Research Hospital located in Bethesda, MD Metro red line (Medical Center stop).

For more information:
NIH Clinical Center Office of Patient Recruitment
800-877-8339 TTY / ASCII
Se habla español

Or go online:
Refer to study #19-C-0033

Department of Health and Human Services
National Institutes of Health Clinical Center (CC)
National Cancer Institute (NCI)

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This page last updated on 10/22/2021

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