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Patient Recruitment

Nivolumab for Patients with IDH-Mutant Gliomas

A Study for Adults With Recurrent IDH1 or IDH2 Mutated Gliomas

doctor and patient reviewing MRI results

National Cancer Institute (NCI) researchers are conducting a study of patients with IDH-mutated gliomas. This study will test whether stimulating the immune system using the drug nivolumab can shrink recurrent IDH-mutant gliomas with and without hypermutator phenotype or increase the time it takes for them to grow or spread.

What the study involves:

  • Full physical and neurological examination
  • Health and symptoms questionnaire
  • MRIs and laboratory tests
  • Study of tumor tissue from prior surgeries
  • Receive drug nivolumab for up to 20 treatments over 64 weeks
  • Your samples used for genetic and biomarker testing
  • Monitoring calls every six months after treatment
  • Visits every month during treatment and 28, 60, 100 days after treatment
  • All tests, procedures and medications provided at no cost

You can participate if you:

  • Are age 18 or older
  • Are diagnosed with a glioma with IDH1or IDH2 mutation that has returned
  • Do not have hepatitis
  • Are not pregnant or breastfeeding

The NIH Clinical Center, America's Research Hospital located in Bethesda, MD Metro red line (Medical Center stop).

For more information:
NIH Clinical Center
Office of Patient Recruitment
800-411-1222 (refer to study 19-C-0006)
800-877-8339 TTY/ASCII
Se habla español
Email: prpl@cc.nih.gov

Or go online:
https://go.usa.gov/x7rmn

Department of Health and Human Services
National Institutes of Health Clinical Center (CC)
National Cancer Institute (NCI)

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This page last updated on 10/22/2021

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