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Patient Recruitment

Clonal Hematopoiesis of Indeterminate Potential (CHIP)

Have You Been Diagnosed With Clonal Hematopoiesis of Indeterminate Significance (CHIP)?

a magnifying glass over a drop of blood

a doctor holding a vial of blood

Doctors at the National Institutes of Health (NIH) are conducting a study on patients with clonal hematopoiesis of indeterminate potential (CHIP). Patients with CHIP have a genetic mutation that has been associated with blood cancer. The study will look at CHIP and try to determine its relationship to blood cancers and heart disease. The study will also try to discover other new organs or diseases that may be linked with.

Study Involves:

  • Yearly medical evaluations over a 10-year period
  • Blood and urine sampling
  • Heart and liver imaging, lung function testing, DEXA scan
  • Optional CT coronary angiography and PET/CT
  • Travel, lodging and compensation for procedures

You may be eligible if you:

  • Are at least 18 years old
  • Have a diagnosis of Clonal Hematopoiesis of Indeterminate Significance (CHIP)
  • Have not had a formal diagnosis of blood cancer or myelodysplastic syndrome
  • Have not been previously treated with chemotherapy or radiation

The NIH Clinical Center, America's Research Hospital is located on the Metro red line (Medical center stop) in Bethesda, Maryland. There is no charge for study-related tests, medications or procedures. Travel assistance may be provided.

For more information:
NIH Clinical Center
Office of Patient Recruitment
800-411-1222 (refer to study # 19-H-0139)
800-877-8339 TTY / ASCII
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Or go online:

Department of Health and Human Services
National Institutes of Health Clinical Center (CC)
National Heart, Lung and Blood Institute (NHLBI)

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This page last updated on 10/22/2021

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