Patient Recruitment Home

Current Protocols

Kids in Research

Healthy Volunteers

ResearchMatch

Participate in Clinical Studies

FAQ About Clinical Studies

Ethics in Clinical Research

Clinical Research Trials and You

CONTACT US

Call toll free: 1-800-411-1222
(TTY 1-866-411-1010)
Se habla español.
Or e-mail: prpl@mail.cc.nih.gov

SEARCH THE STUDIES

You can search the collection of research studies being conducted at the NIH Clinical Center at Search the Studies. In addition, clinicaltrials.gov provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.

Patient Recruitment

Does adding 1-2 experimental therapies improve treatment of GBM?

NIH Brain Cancer Research

a man riding a bike

National Cancer Institute researchers in Bethesda, Maryland, are enrolling participants in the very first study of its kind for a type of brain cancer called glioblastoma or GBM. This research study is testing if adding 1-2 experimental therapies (HSPPC-96 or placebo vaccine and pembrolizumab) improves standard treatment for GBM. All treatment and research procedures are provided at no cost. Travel assistance provided for enrolled participants.

During the study:

  • After brain surgery at the NIH to remove as much of the tumor as possible, patients will receive the standard treatment for GBM: radiation treatment, and temozolomide (TMZ), an oral chemotherapy drug.
  • All patients will also receive an immunotherapy agent called pembrolizumab. The combination of pembrolizumab with standard treatment has been shown to be well-tolerated.
  • Some patients will also receive a vaccine made from part of their own tumor. Researchers want to see if adding this personalized cancer vaccine (HSPPC-96) will improve the effect of pembrolizumab.

You may be eligible if you:

  • Are an adult who has been recently diagnosed with GBM or have a suspected GBM and are eligible to undergo surgery at the NIH
  • Have not already received radiation, chemotherapy or carmustine wafers for your GBM

Location: The NIH Clinical Center, America's research hospital, is conveniently located on the Metro Red Line (Medical Center stop) in Bethesda, Maryland.

For more information, call:
Office of Patient Recruitment
1-800-411-1222
TTY: 1-866-411-1010
Se habla español

Or go online:
clinicaltrials.gov
Refer to study #17-C-0034 or NCT03018288

Department of Health and Human Services
National Institutes of Health Clinical Center (CC)
National Cancer Institute (NCI)

NOTE: PDF documents require the free Adobe Reader.

This page last updated on 09/07/2017

You are now leaving the NIH Clinical Center website.

This external link is provided for your convenience to offer additional information. The NIH Clinical Center is not responsible for the availability, content or accuracy of this external site.

The NIH Clinical Center does not endorse, authorize or guarantee the sponsors, information, products or services described or offered at this external site. You will be subject to the destination site’s privacy policy if you follow this link.

More information about the NIH Clinical Center Privacy and Disclaimer policy is available at http://www.cc.nih.gov/disclaimers.html