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Patient Recruitment

The Pathological Basis of MRI Signal Changes in Multiple Sclerosis

The LIFE Study

The LIFE Study - Pathological Basis of MRI Signal Changes in Multiple Sclerosis

Multiple sclerosis (MS) is a disease that damages the central nervous system (brain and spinal cord). This leads to increased physical disability over time. The disease is lifelong once it begins. Researchers want to learn more about the stages of multiple sclerosis and follow them until a person’s death to understand how the physical and clinical signs of MS relate to its changes over time.

You are eligible if you:

  • Are age 18 or older
  • Have MS or a disease of the brain and spinal cord that may act like MS

Study Details:

  • Medical history and a complete neurological exam
  • Timed tests of neurological function, such as a 25-foot walk and a nine-hole peg test
  • Multi-day visits to Bethesda, Maryland for up to 30 years or more
  • Autopsy at the time of their death and to donate organs, such as the brain and spinal cord to research
  • Compensation will not be provided for specific research procedures
  • Participants' travel costs will be covered
  • In cases of need (e.g., disability), travel costs for a companion will also be provided

For more information:
NIH Clinical Center
Office of Patient Recruitment
800-411-1222 (refer to study 16-N-0055)
800-877-8339 TTY/ASCII
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Or go online:

Department of Health and Human Services
National Institutes of Health Clinical Center (CC)
National Institute of Neurological Disorders and Stroke (NINDS)

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This page last updated on 10/22/2021

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