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Patient Recruitment

Do You Have Dry Mouth Due to Radiation Therapy?

a woman drinking a glass of water

Researchers at the National Institutes of Health (NIH), in Bethesda, Maryland, are testing if an investigational gene therapy using "AAV2hAQP1" increases saliva production in patients with dry mouth related to radiation therapy for head and neck cancer.

Consider participating if you:

  • Are at least 18 of age Have a history of radiation therapy for head and neck cancer Experience dry mouth
  • Have been free of head and neck cancer for the last 5 years and free from all other cancers for the last 3 years

You cannot participate if you:

  • Are a female who is pregnant or breast feeding
  • Use systemic corticosteroids such as prednisone (topical corticosteroids are allowed)
  • Have an autoimmune disease that affects the salivary glands
  • Smoke

What is involved?

  • All participants will receive investigational AAv2hAQP1 gene therapy
  • A medical history, physical exam, saliva collections
  • A 3-day hospital stay and 10 outpatients visits over 3 years
  • There is no cost for study-related medications, tests, or procedures
  • Travel to and from the Clinical Center (within the U.S.) will be provided

The NIH Clinical Center is America's Research Hospital located in Bethesda, Maryland, on the Metro red line (Medical Center stop).

For more information, call:
NIH Clinical Center
Office of Patient Recruitment
TTY: 1-866-411-1010
Se habla español

Or go online:
Refer to study # 15-D-0129

Department of Health and Human Services
National Institutes of Health Clinical Center (CC)
National Institute of Dental and Craniofacial Research (NIDCR)

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This page last updated on 10/22/2021

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