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You can search the collection of research studies being conducted at the NIH Clinical Center at Search the Studies. In addition, provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.

Patient Recruitment

Phase II Trial of Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for Treatment of Bronchiolitis Obliterans

Are you struggling with Bronchiolitis Obliterans after a stem cell transplant?

a man resting during a jog in the park

Bronchiolitis obliterans is a lung disorder that can occur as a complication following bone marrow/blood stem cell transplantation. Researchers at the National Institute of Health (NIH) Clinical Center in Bethesda, Maryland, want to evaluate if inhaled cyclosporine can be used to improve or stabilize lung function in people with bronchiolitis obliterans.

One current treatment for bronchiolitis obliterans is taking cyclosporine by mouth as a pill. This type of treatment is not fully effective and may cause serious side effects. This study is evaluating if taking inhaled cyclosporine will provide a higher concentration of medication directly to the lungs and decrease the risk for side effects.

Participation includes:

  • A full medical history and physical examination including lung function test, imaging scans, and quality of life questionnaires
  • Study visits every three weeks
  • Taking inhaled cyclosporine for a minimum of 18 weeks, followed by a final follow-up visit two weeks after the end of the study
  • You might be eligible to continue to take inhaled cyclosporine as part of a follow up study
  • All treatment and research procedures are provided at no cost to you. Travel assistance provided for enrolled participants

You may be eligible if you:

  • Are 10-80 years old and not pregnant or breastfeeding
  • Developed bronchiolitis obliterans and it's been at least 99 days after a peripheral blood transplant
  • Have no evidence of pulmonary infection

Location: The NIH Clinical Center, America's research hospital, is conveniently located on the Metro Red Line (Medical Center stop) in Bethesda, Maryland.

For more information, call:
Office of Patient Recruitment
TTY: 1-866-411-1010
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Or go online:
Refer to study #11-H-0068

Department of Health and Human Services
National Institutes of Health Clinical Center (CC)
National Heart, Lung, and Blood Institute (NHLBI)

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This page last updated on 09/19/2017

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