Richard Chang, MD
Chief, Endocrine and Venous Services Section, Interventional Radiology Section
Radiology and Imaging Sciences
BA, Columbia University
MA, Physics, Princeton University
MD, Johns Hopkins School of Medicine
Dr. Chang earned his medical doctorate from the Johns Hopkins School of Medicine in 1976. After a medical internship at St. Luke’s Hospital in New York City, he returned to Johns Hopkins Medical Institutions to complete residency training in Diagnostic Radiology between 1977 to 1980, and then joined the faculty there as a staff member in Interventional Radiology where he worked for the ensuing five years providing patient care and training residents and fellows. In 1985 Dr. Chang joined the Radiology Department at NIH to work with Dr. John L. Doppman, a world-renowned radiologist and then Chief of the Radiology Department at NIH. In addition to providing venous access device placements, drainage procedures, and biopsies to support NIH protocols, Dr. Chang provides special expertise to the Clinical Center in certain areas. Under Dr Doppman’s guidance, instruction, collaboration, and support, Dr. Chang acquired additional experience and expertise in endocrine localization studies, and spinal arteriography, that were essential parts of clinical research programs at NIH. These programs have been so successful that the NIH Clinical Center serves as a national and international resource for patients with small endocrine tumors that could not be localized elsewhere.
With collaboration with members of the Hematology Department, Dr. Horne (now retired) and Dr. Lozier, Dr. Chang has conducted important clinical research studies in thrombolytic therapy for venous thrombus aimed at making thrombolytic therapy for venous thrombosis effective, yet safer, less expensive, and simpler than currently available regimens. Studies have been conducted and completed that demonstrate that effective thrombolytic therapy can be provided by injecting tissue plasminogen activator (r-tPA or alteplase) directly into thrombus only once a day without the need for continuous infusion therapy permitting outpatient regimens for treating upper extremity or central venous thrombosis, and allowing for improved safety of thrombolytic therapy by decreasing the duration of systemic exposure to circulating thrombolytic agents. Dr. Chang was appointed Chief of the Interventional Radiology Section in 1993. Dr. Chang’s special research interests continue to be in improving diagnosis and localization of endocrine tumors and in improving treatments for venous thrombosis.
Chang R, Horne MK III, Mayo DJ, Doppman JL. Pulse-Spray Treatment of Subclavian and Jugular Venous Thrombi with Recombinant Tissue Plasminogen Activator. JVIR 1996;7:845-851.
Horne MK, Mayo DJ, Cannon RO, Chen CC, Shawker TH, Chang R. Intraclot Recombinant Tissue Plasminogen Activator in the Treatment of Deep Venous Thrombosis of the Lower and Upper Extremities. AJM 2000;108:251-255.
Chang R, Cannon RO III, Chen CC, Doppman JL, Shawker TH, Mayo DJ, Wood B, Horne MK III. Daily Catheter-directed Single Dosing of t-PA in Treatment of Acute Deep Venous Thrombosis of the Lower Extremity. J Vasc Interv Radiol 2001;12:247-252.
Alexander R, Chen C, Shawker T, Choyke P, Chan T, Chang R and Marx S. Role of Preoperative Localization and Intraoperative Localization Maneuvers Including Intraoperative PTH Assay Determination for Patients With Persistent or Recurrent Hyperparathyroidism. JBMR 2002, 17:N133-140
Hirshberg B, Libutti SK, Alexander HR, Bartlett DL, Cochran C, Livi A, Chang R, Shawker T, Skarulis MC, Gorden P. Blind distal pancreatectomy for occult insulinoma, an inadvisable procedure. J Am Coll Surg. 2002 Jun;194(6):761-4
Horne MK III, Chang R. Pharmacokinetics of pulse-sprayed recombinant tissure plasminogen activator for deep vein thrombosis. Thromb Res 2003; 111: 111-114.
Hirshberg B, Rother KI, Digon BJ 3rd, Lee J, Gaglia JL, Hines K, Read EJ, Chang R, Wood BJ, Harlan DM. Benefits and risks of solitary islet transplantation for type 1 diabetes using steroid-sparing immunosuppression: the National Institutes of Health experience. Diabetes Care. 2003 Dec;26(12):3288-95.
Rosenberg SA, Yang JC, Robbins PF, Wunderlich JR, Hwu P, Sherry RM, Schwartzentruber DJ, Topalian SL, Restifo NP, Filie A, Chang R, Dudley ME Cell transfer therapy for cancer: lessons from sequential treatments of a patient with metastatic melanoma. J Immunother. 2003 Sep-Oct;26(5):385-93
Ilias I, ChangR, Pacak K, Oldfield EH, Wesley R, Doppman J, Nieman LK. Jugular venous sampling: An alternative to petrosal sinus sampling for the diagnostic evaluation of adrenocorticotrophic hormone dependent Cushing’s syndrome. J Clin Endocrinol Metab 2004 Aug; 89 (8) : 3795-800.
Chang R, Chen CC, Kam A, Mao E, Shawker TH, Horne MK III. Deep Vein Thrombosis of Lower Extremity: Direct Intraclot Injection of Alteplase Once Daily with Systemic Anticoagulation—Results of Pilot Study . Radiology 2008 246: 619-629