Department of Laboratory Medicine
IQGAP1 and Salmonella Pathogenesis
Pathogenic microbes have evolved diverse strategies to invade the host, avoid the innate immune response and multiply. The invasion of human cells by pathogens is observed in food-borne illnesses caused by Salmonella, Shigella and Listeria as well as periodontal (gum) infections. Microbial invasion of host cells is largely achieved by the pathogens' usurping of host signaling pathways. A common target of pathogens is the host cell's actin cytoskeleton, which the microbes use for attachment, entry into cells, movement within and between cells and avoidance of phagocytosis.
The actin-binding protein IQGAP1 is an established regulator of normal cytoskeletal function and may play a role in the invasion of human cells by microbial pathogens. My laboratory is presently investigating the IQGAP1-mediated mechanisms by which Salmonella subverts the actin cytoskeleton to establish infection.
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This page last updated on 06/09/2017