Department of Laboratory Medicine

Samar Sayedyahossein Curriculum Vitae

Educational History

2015-present Postdoctoral Fellow, National Institutes of Health, Bethesda, MD, USA Supervisor: Dr. David Sacks, Project: "IQGAP1 as a scaffold in signal transduction"
2014-2015 Postdoctoral Fellow, Department of Physiology and Pharmacology
The University of Western Ontario, London, Ontario, Canada, Supervisor: Dr. Lina Dagnino, Project: "Role of Integrin-linked Kinase in Epidermis Structure and Barrier Function"
2010-2014 PhD Candidate, Department of Physiology and Pharmacology
The University of Western Ontario, London, Ontario, Canada, Supervisor: Dr. Lina Dagnino, Project: "Role of Integrin-linked Kinase in Epidermis Structure and Barrier Function"
2008-2010 MSc candidate, Department of Immunology and Microbiology.
The University of Western Ontario, London, Ontario, Canada Supervisor: Dr. Joaquín Madrenas, Project: "Immunomodulatory effect of Staphylococcus aureus Peptidoglycan"
(Reclassified to PhD in Physiology and Pharmacology)
1999-2007 Medical Doctorate Degree
Isfahan University of Medical Sciences, Isfahan, Iran, Project Advisor: Dr. Mohammad Hassan Emami, Project: "The effect of suppository GTN on chronic anal fissure"
Samar Sayedyahossein

Publications & Contributions

Peer-Reviewed Papers

  1. B. Chawla, A C. Hedman, H H. Erdemir, S. Sayedyahossein, Z. Li, D B. Sacks. Absence of IQGAP1 leads to insulin resistance. JBC. 2017 January 12. doi: 10.1074/jbc.M116.752642

  2. S. Choi, A C. Hedman, S. Sayedyahossein, N. Thapa, D B. Sacks and R A. Anderson. Agonist-stimulated PI 3,4,5 P3 generation by scaffolded phosphoinositide kinases. Nature Cell Biology, 2016.doi:10.1038/ncb3441. [This paper was contracted a News and Views commentary by Nature Cell Biology editors: Nat Cell Biol. 2016 Nov 29;18(12):1263-1265. doi: 10.1038/ncb3440

  3. S. Sayedyahossein, Z. Li, A C. Hedman, C. Morgan and D B. Sacks. IQGAP1 modulates YAP transcriptional activity. JBC, 2016 Jul 20. doi: 10.1074/jbc.M116.732529

  4. S. Sayedyahossein, A. Rudkouskaya, V. Leclerc and L. Dagnino. Integrin-linked kinase is indispensable for keratinocyte differentiation and epidermal barrier function, J Invest Dermatol, 2016 Feb;136(2):425-435. doi:10.1016/j.jid.2015.10.056

  5. S. Sayedyahossein, S. X. Xu, A. Rudkouskaya, M. J. McGavin, J. K. McCormick and L. Dagnino. Staphylococcus Aureus Keratinocyte Invasion is mediated by Integrin-Linked-Kinase and Rac1, FASEB Journal, 2015 Feb; 29(2):711-23.

  6. L. Vi, S. Boo, S. Sayedyahossein, R. Singh, S. McLean; G. Di Guglielmo and L. Dagnino. Modulation of type II TGF-β receptor degradation by integrin-linked kinase. J Invest Dermatol. 2015 Mar;135(3):885-94.

  7. S. Sayedyahossein, L. Nini, TS. Irvine, and L. Dagnino. Essential role of integrin-linked kinase in regulation of phagocytosis in keratinocytes. FASEB Journal 2012; 26(10): 4218-4229.

  8. V. Frodermann, TA. Chau, S. Sayedyahossein, JM. Toth, DE. Heinrichs, J. Madrenas. A Modulatory Interleukin-10 Response to Staphylococcal Peptidoglycan Prevents Th1/Th17 Adaptive Immunity to Staphylococcus aureus. J Infect Dis. 2011; 204(2): 253-262.

  9. M.H. Emami, S. Sayedyahossein. A. Aslani. Safety and Efficacy of New Glyceryl Trinitrate Suppository Formula: First Placebo Controlled Clinical Trial. Disease of the Colon & Rectum 2008; 51 (7): 1079-1083.

Invited Reviews

  1. S. Sayedyahossein and L. Dagnino. Role of Integrins and their associated proteins in phagocytosis. Int. Rev. in Cell. Mol. Biol. 2013; 302:321-354.

  2. M.H. Emami, S. Sayedyahossein. Chronic Anal Fissure: New Approaches to Chemical Sphincterotomy. JRMS 2008; 13(3): 149-155.

  3. AH. Zargarzadeh, S. Sayedyahossein. Evidence Based Medicine: Current Challenges and Views. Isfahan Journal of Medical Society 2004; 8(17): 24-26.

  4. S. Sayedyahossein. How to Write a Scientific Article. JRMS 2001; 6(2): 158-160.

Selected Oral Presentations

  1. S. Sayedyahossein, A. Rudkouskaya and Lina Dagnino. Role of integrin-linked kinase in epidermal integrity and barrier function. Gordon Research Conference, Tuscany, Italy, May 10-15, 2015.

  2. S. Sayedyahossein, A. Rudkouskaya, S. X. Xu, J. K. McCormick and Lina Dagnino. ILK modulates Staphylococcus aureus invasion of keratinocytes. London Health Research Day, March 18, London, ON, Canada 2014.

  3. S. Sayedyahossein, S. X. Xu, J. K. McCormick and L. Dagnino. Integrin-linked Kinase Modulates Phagocytosis in Epidermal Keratinocytes. London Health Research Day, March 19, London, ON, Canada 2013.

  4. S. Sayedyahossein, S. X. Xu, J. K. McCormick and L. Dagnino. Integrin-linked Kinase Modulates Phagocytosis in Epidermal Keratinocytes. Gordon Research Seminar, February 9-10, Ventura CA, USA 2013.

  5. S. Sayedyahossein, L. Nini, T. Irvine and L. Dagnino. Essential Role of Integrin-linked Kinase in Regulation of Phagocytosis in Keratinocytes. Great Lakes Mammalian Development 2012, April 12-14, Toronto, CA 2012.

  6. S. Sayedyahossein, T. Chau, D. Heinrichs, and J. Madrenas. Plasticity of TLR2-mediated Regulation of Adaptive T Cell Responses: Learning from Staphylococcus Aureus. Accepted for oral presentation at 10th Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010), June 24-27, Boston, USA 2010.

  7. S. Sayedyahossein, T. Chau, D. Heinrichs, and J. Madrenas. The Type of Primary Antigen-presenting Cell Determines the Immunomodulatory Capacity of Staphylococcal Peptidoglycan-embedded Molecules. Oral presentation at IIRF, University of Western Ontario 2009.

  8. S. Sayedyahossein, Kh. Shahsavarizadeh, M.H. Emami, A. Aslani, Safety and Efficacy of New Glyceryl Trinitrate Suppository Formula: First Double Blind Placebo Controlled Clinical Trial (phase III). Oral presentation in the First International Congress of Medical Students in Iran 2007.

Honors and Awards

2015 Margaret P. Moffat Award of Outstanding PhD Thesis
Physiology and Pharmacology Research Day, The University of Western Ontario
2014 Second Place Poster Presentation Award
Physiology and Pharmacology Research Day, The University of Western Ontario
2014 Mogenson and Sharma Research Scholarship
Schulich School of Medicine, Dept. Physiology and Pharmacology, The University of Western Ontario
2013 Second Place Poster Presentation Award
Physiology and Pharmacology Research Day, The University of Western Ontario
2013 Graduate Thesis Research Award
The University of Western Ontario
2013 CHRI Trainee Travel Award
Children Health Research Institute
2012 First Place Poster Presentation Award
Physiology and Pharmacology Research Day, The University of Western Ontario
2012 Graduate Thesis Research Award
The University of Western Ontario
2011 Second Place Poster Presentation Award
Physiology and Pharmacology Research Day, The University of Western Ontario
2011 CHRI Trainee Travel Award
Children Health Research Institute
2010 FOCIS 10th Annual Meeting, Travel Award
Federation of Clinical Immunology Societies (FOCIS), Robarts Research Institute, The University of Western Ontario
2010 Western Graduate Research Scholarship (WGRS), $10,500/Year
The University of Western Ontario
2010 Graduate Thesis Research Award
The University of Western Ontario
2009 Graduate Thesis Research Award
The University of Western Ontario
2009 FOCIS 10th Annual Meeting, Travel Award
Federation of Clinical Immunology Societies (FOCIS), Robarts Research Institute, The University of Western Ontario
2007 UNESCO- L'OREAL Scholarship for Young Women In Life Sciences Nominee From Iran
2007 Pioneer Student Award
Isfahan University of Medical Sciences
2005 Student Award of Excellence
Isfahan University of Medical Sciences
2004 National Award of Leadership in Global Education
Jahad Daneshgahi, Tehran, Iran

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