Department of Laboratory Medicine

Educational History

• 2017, Doctor of Philosophy, Biochemistry and Molecular Biology, Howard University
• 2011, Master of Science, Biotechnology, Georgetown University
• 2007, Master of Science, Industrial Biotechnology, Bharathiar University
• 2005, Bachelor of Science, Biotechnology, Osmania University

Employment History

• Jan 2018 – Oct 2019, Post-doctoral Fellow, Howard University, Washington DC
• Jan 2012 – Dec 2017, Research Assistant, Howard University, Washington DC
• Jul 2011 – Dec 2011, Research Associate, Kamtek Inc, Gaithersburg, Maryland

Publications & Contributions

Peer-Reviewed Papers

• Parvathaneni, Swetha, and Sudha Sharma. "The DNA repair helicase RECQ1 has a checkpoint-dependent role in mediating DNA damage responses induced by gemcitabine." Journal of Biological Chemistry (2019): jbc-RA119.
• Sharma, Pooja, Sarah Alsharif, Karina Bursch, Swetha Parvathaneni, Dimitrios G. Anastasakis, Joeffrey Chahine, Arwa Fallatah et al. "Keratin 19 regulates cell cycle pathway and sensitivity of breast cancer cells to CDK inhibitors." Scientific Reports 9, no. 1 (2019): 1-12.
• Parvathaneni, Swetha, Xing Lu, Ritu Chaudhary, Ashish Lal, Srinivasan Madhusudan, and Sudha Sharma. "RECQ1 expression is upregulated in response to DNA damage and in a p53-dependent manner." Oncotarget 8, no. 44 (2017): 75924.
• Woodrick, Jordan, Suhani Gupta, Sharon Camacho, Swetha Parvathaneni, Sujata Choudhury, Amrita Cheema, Yi Bai et al. "A new sub‐pathway of long‐patch base excision repair involving 5′ gap formation." The EMBO journal 36, no. 11 (2017): 1605-1622.
• Arora, Arvind, Swetha Parvathaneni, Mohammed A. Aleskandarany, Devika Agarwal, Reem Ali, Tarek Abdel-Fatah, Andrew R. Green et al. "Clinicopathological and functional significance of RECQL1 helicase in sporadic breast cancers." Molecular cancer therapeutics 16, no. 1 (2017): 239-250.
• Li, Xiao Ling, Murugan Subramanian, Matthew F. Jones, Ritu Chaudhary, Deepak K. Singh, Xinying Zong, Berkley Gryder et al. "Long noncoding RNA PURPL suppresses basal p53 levels and promotes tumorigenicity in colorectal cancer." Cell reports 20, no. 10 (2017): 2408-2423.
• Lu, Xing, Swetha Parvathaneni, Xiao Ling Li, Ashish Lal, and Sudha Sharma. "Transcriptome guided identification of novel functions of RECQ1 helicase." Methods 108 (2016): 111-117.
• Sami, Furqan, Xing Lu, Swetha Parvathaneni, Rabindra Roy, Ronald K. Gary, and Sudha Sharma. "RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin." Biochemical Journal 468, no. 2 (2015): 227-244.
• Li, Xiao Ling, Xing Lu, Swetha Parvathaneni, Sven Bilke, Hongen Zhang, Saravanabhavan Thangavel, Alessandro Vindigni et al. "Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion." Cell Cycle 13, no. 15 (2014): 2431-2445.
• Lu, Xing, Swetha Parvathaneni, Toshifumi Hara, Ashish Lal, and Sudha Sharma. "Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D." Molecular cancer 12, no. 1 (2013): 29.
• Parvathaneni, Swetha, Alexei Stortchevoi, Joshua A. Sommers, Robert M. Brosh Jr, and Sudha Sharma. "Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks." PLoS One 8, no. 5 (2013): e62481.

Oral Presentations

• 2017 - Novel function of RECQ1 in mediating cellular response to Gemcitabine treatment in triple negative breast cancer, Emerging Researchers Network conference, Washington DC.
• 2017 - Investigating a novel role of RECQ1in estrogen signaling through regulation of estrogen receptor α  expression in breast cancer cells, Edward Bouchet Induction Ceremony, Yale University, Connecticut.
  

Book Chapter

• Role of zinc-binding domain of RecQ helicases, chapter for “Helicases from all domains of life” 1st Edition. September 2018, Elsevier.

Honors and Awards