- Overview of Bench-to-Bedside Program
- Source of Funds
- Who May Apply
- Resources for Applicants
- Peer Review of Applications
- Annual Progress Reports
- Appendix: Bench-to-Bedside by the Numbers
Originally established in 1999 to integrate the work of basic and clinical scientists on the NIH campus, the BtB Program expanded in 2006 to encourage partnerships between intramural and extramural programs.
These two-year awards are designed to seed new projects that propose to translate basic science to human subjects research. Each award provides $150,000 per year, not including indirect costs. 255 projects have been funded since 1999, with more than 900 investigators receiving awards.
BtB proposals can fall into one of seven categories: AIDS, behavioral and social sciences, dietary supplements, general (intramural-only projects), minority health, rare diseases and women's health projects.
All BtB teams should involve an intramural investigator PLUS one or more investigator(s) from another institute and/or an extramural partner(s). For awards involving extramural partners, extramural funds will be as awarded via an administrative supplement to an existing NIH grant.. Among other stipulations, the grant vehicle should have commitments for both FY 2018 and FY 2019, and be active through May 31, 2020, and the support must be consistent with the approved aims and objectives of the grant.
Funding for BtB Awards is provided in the following research categories by the entities listed below:
(1) AIDS: Exemplary HIV/AIDS projects aligned with the new overarching HIV/AIDS research priorities will be funded.
(2) Behavioral and Social Sciences (Support from the NIH Office of Behavioral and Social Sciences Research): Projects will be considered for funding that facilitate the translation of basic behavioral and social science research findings into effective interventions to prevent disease and to promote and optimize health. Of particular interest are interdisciplinary research and systems thinking and modeling approaches that integrate multiple levels of analysis - from cells to society - of factors that influence health. Key problems in population health where scientists, practitioners, and decision-makers can work together to accelerate the translation, implementation, dissemination, and adoption of behavioral and social sciences research findings are of high priority to OBSSR. The Office has strong interests in the development of behavioral interventions to improve health, studies of gene-environment interactions, adherence (at the patient and provider levels), measurement harmonization, primary care, mobile health, health disparities, shared medical decision-making, the exposome, and other areas.
(3) Dietary Supplements (Support from the Office of Dietary Supplements): Awards in this funding category are designed to promote scientific study of the benefits of dietary supplements in maintaining health and preventing chronic disease and other health-related conditions but not in disease treatment. In the U.S., these ingredients are usually defined as including plant extracts, enzymes, vitamins, minerals amino acids, and hormonal products that are available without prescription and are consumed in addition to the regular diet.
(4) Minority Health and Healthy Disparities (Support from the National Institute on Minority Health & Health Disparities): The National Institute on Minority Health and Health Disparities (NIMHD) will fund projects that promote the science of understanding behavioral, biological, environmental and health system factors that are unique to the minority groups in the US (defined by the US Census as Black/African American, Asian, American Indian/Alaska Native, Pacific Islander, and Latino/Hispanic). NIMHD will also fund projects that advance the science of understanding the factors that lead to adverse outcomes or health disparities in minority groups, persons of low socioeconomic status, rural residents, and sexual gender minorities. These projects must focus on an area of science/research that supports the overall NIH effort to reduce health disparities.
(5) Rare Diseases (Support from Office of Rare Diseases Research in the National Center for Advancing Translational Sciences): Projects must focus on an area of science/research directly related to a rare disease. An orphan or rare disease is generally considered to have a prevalence of less than 200,000 affected individuals in the United States. Certain diseases with more than 200,000 affected individuals are included but subpopulations of these conditions may be less than the prevalence standard for a rare disease. A comprehensive list of rare diseases, updated regularly, is available at http://rarediseases.info.nih.gov/RareDiseaseList.aspx?PageIC=1.
(6) Women's Health (Support from the Office of Research on Women's Health): Projects will be considered that focus on efforts to improve the health of women through biomedical and behavioral research on the roles of sex and gender in health and disease with particular interest in comparing and contrasting female and male data from cells, animals, tissues in the context of a range of research questions relevant to diseases that affect women. Additional information about ORWH’s strategic priorities can be found here:: http://orwh.od.nih.gov/research/strategicplan/ORWH_StrategicPlan2020_Vol1.pdf (1.26 MB)
(7) General: Additional meritorious projects that don't fall within the scope of the categories listed above will be considered for funding in the "general" category.
As in prior years, intramural investigators in all institutes/centers are eligible to serve as project leaders on proposals. At least one intramural investigator on the project must have responsibility for scientific and budgetary oversight (e.g., the investigator must have a budget/assigned CAN and resources).
Extramural principal investigators (PIs) with an existing NIH grant (e.g., researchers at CTSA or AIAMC sites) are invited to initiate proposals in one of two ways.
- Extramural investigators may seek an intramural partner at NIH who would function as the project leader and serve as the point of contact. To identify an intramural collaborator, extramural investigators may consult a number of NIH resources:
- NIH's database of all current intramural research: http://intramural.nih.gov/search/index.taf
- Intramural Principal Investigator Directory at http://irp.nih.gov/our-research/principal-investigators;
- "Search the Studies" website to identify investigators on relevant protocols at http://clinicalstudies.info.nih.gov/index.html; or
- Extramural investigators may also consult the Bench-to-Bedside Program Office (BenchtoBedside@mail.nih.gov) for assistance in identifying intramural partners.
- Extramural investigators may initiate proposals and serve as project leaders. In this role, extramural principal investigators will develop letters of intent and if approved, may develop full proposals. In this scenario, extramural investigators are required to identify an intramural collaborator on the project. On behalf of the lead extramural PI, the intramural investigator will be responsible for submitting both the letter of intent and full proposal electronically using proposalCentral.
For inquiries regarding the BtB Program, including questions related to the content of your LOI and full proposal, please contact BtB Program staff at BenchtoBedside@mail.nih.gov.
For questions about using ProposalCentral, please refer to the following resources:
- Tip Sheet #1 for creating a ProposalCentral Account and submitting your Letter of Intent (47 KB)
- Tip Sheet #2 for submitting your full proposal (20 KB)
- ProposalCentral's customer support hotline:
- Toll free phone: 800-875-2563
- Direct dial international: 703-964-5840
- Email: email@example.com
A review team, appointed by the Director, NIH Clinical Center, reviews and ranks the proposals. The team includes both intramural and extramural basic and clinical scientists representing multiple institutes and centers, and includes expertise in the funded research categories. Considerations for review include:
- High quality of science (to be evaluated by the NIH Enhanced Review Criteria for Research Grants and Cooperative Agreements) with the potential to result in understanding an important disease process or lead to new therapeutic intervention;
- Strong translational science, with the bedside and bench components clearly related; one should lead logically to the next, and both should be strongly developed;
- The proposed translational work has the promise to evolve into an active clinical protocol with patient involvement in the future*
- Although projects can be exclusively among intramural investigators preferably from more than one IC, collaborations between intramural and extramural investigators will receive priority review;
- The work should be a truly new initiative, not a funding request for work in progress.
*Translational component section: Applicants will be required to explain how their proposed project will involve clinical work with direct patient contact, OR how the results of their proposal will lead to next steps involving clinical work (ultimately with direct patient contact), with involvement at the Clinical Center a preference but not a requirement. Projects can include studies of patients, then, laboratory studies and then, back to patient studies.
If you have specific questions about the peer review process, please contact BtB staff at BenchtoBedside@mail.nih.gov.
Principal Investigators for all awarded projects will be required to submit annual progress reports on each project's status. BtB Program Staff will provide a template for the report and advance notice regarding the due date. See the current progress report templates.
147 Awards at 82 U.S. and International Sites
|Albert Einstein College of Medicine
Baylor College of Medicine
Benaroya Research Institute
Beth Israel Medical Center
Case Western Reserve University
Catholic University of America
Children's Hospital & Clinics of Minnesota
Children's Hospital of Philadelphia
Children's National Medical Center
Cincinnati Children's Medical Center
Fred Hutchinson Cancer Center
Food and Drug Administration
George Washington University
Gynecologic Oncology Group
Hackensack University Medical Center
INOVA Fairfax Hospital
Johns Hopkins University
Ludwig Institute for Cancer Research
Massachusetts General Hospital
|Mayo Clinic, Rochester, MN
Mayo College of Medicine
MD Anderson Cancer Center
Medical University of South Carolina
National Naval Medical Center
Nationwide Children's Hospital
Oklahoma University Health Sciences Center
Oregon State University
Prince George's County Hospital
The Rockefeller University
San Francisco General Hospital
Sanford Burnham Research Institute
Science Applications Int'l Corp
St. Michael's Medical Center
State University of New York
Uniformed Services University of the Health Sciences
University of California, Davis
University of California, Los Angeles
University of California, San Diego
University of California, San Francisco
|University of Central Florida
University of Cincinnati
University of Louisville
University of Maryland
University of Maryland Baltimore
University of Massachusetts Amherst
University of Massachusetts Medical School Worcester
University of Miami
University of Michigan
University of Minnesota
University of North Dakota
University of Oklahoma
University of Pennsylvania
University of Pittsburgh
University of South Carolina
University of Virginia
University of Washington
University of Wisconsin
US Food and Drug Administration
Walter Reed Army Medical Center
Washington Hospital Center
Washington University in St. Louis
Weill Cornell Medical College
10 International Partnerships
- Hospital A. C. Camargo, Brazil
- Hospital for Sick Children, Canada
- Imperial College London, UK
- International Agency for Research on Cancer, France
- Makerere University, Uganda
- Sackler School of Medicine, Israel
- University of New South Wales, Australia
- University of Toronto, Canada
- University of Oxford, UK
- Zaria, Nigeria
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This page last updated on 06/12/2017