Bench-to-Bedside Program

2007 Bench-to-Bedside Funded Projects

GENERAL CATEGORY:

Project Institute or institution/Investigators
Dynamic Measurement and modeling of Immune Homeostasis and Reconstitution in Pre-clinical and Clinical Studies of Cytokine Therapy and Allogeneic Hematopoietic Stem Cell Transplantation (AHSCT) NCI: Gress, Ron; Chu, Yu-Waye; Hakim, Fram; Telford, William; Sidorov, Igor; Dimitrov, Dimiter Hackensack
University Medical Center: Korngold, Robert

AIDS CATEGORY:

Project Institute or institution/Investigators
Intensification of Antiretroviral Therapy Using HIV Integrase Inhibitor (MK-0518) to Assess Decay of Viral Reservoirs in Peripheral Blood and Gut-Associated Lymphoid Tissue of Chronically Infected Patients NIAID: Chun, Tae-Wook ; Moir, Susan; Kottilil, Shyam
CC: Healy, Letha; Penzak, Scott R.
University of Toronto: Kovacs, Colin; Loufty, Mona
George Washington University: Ward, Douglas
Humoral Response Profiling of Viral and Cellular Tumor Antigens for Predicting, Diagnosing, and Monitoring HIV Malignancies NIDCR: Burbelo, Peter; Iadorola, Michael
CC: Kovacs, Joseph; Healy, Letha
1H Magnetic Resonance Spectroscopy for Quantification of Hepatic Triglyceride Content: Validation and Application in HIV-infected Patients NIAID: Berger, Ed
University of Washington: Casper, Corey
Development of Immunotoxins against Kaposi’s Sarcoma Associated Herpesvirus for Treatment of Multicentric Castleman’s Disease (MCD) NIAID: Berger, Ed
University of Washington: Casper, Corey

RARE DISEASES CATEGORY:

Project Institute or institution/Investigators
Antiproliferative Therapy for Severe Pulmonary Arterial Hypertension  NHLBI: Boehm, Manfred; Machado, Roberto; Gladwin, Mark
CC: Cuttica, Michael J.; Cochard, Audrey; Barnett, Christopher
Inova Fairfax Hospital: Nathan, Steven
Characterization of Glycosphingolipid Accumulation in Smith-Lemli-Opitz Syndrome and Treatment with N-butyldsoxynojirimycin NICHD: Porter, Forbes
University of Oxford (UK): Platt, Fran
Life-Threatening Pulmonary Complications of Organ Transplantation: An Investigation of the Pathogenesis of Bronchiolitis Obliterans and Its Novel Treatment with Aerosolized Liposomal Cyclosporine A NHLBI: Childs, Richard
CC: Suffredeini, Anthony; Danner, Robert
University of Maryland: Iacono, Aldo; Griffith, Bartley; Terrin, Michael
Role of Pathogen-specific IgE and histamine release in the hyper-IgE syndrome NIAID: Freeman, Alexandra; Holland, Steve; Welch, Pam; DeCastro, Rosamma; Anderson, Victoria
NCI: Turner, Maria
NHGRI: Davis, Joie
CC: Darnell, Dirk
Uniformed Services University of Health Sciences: Mitre, Edward; Torrero, Marina; Hubner, Marc; Larson, David
University of California, San Francisco: Puck, Jennifer
WAGR Syndrome: Clinical Characterization and Correlation with Geneotype NICHD: Han, Joan; Lu, Bai; Rennert, Owen; Yanovski, Jack
NEI: Brooks, Brian
NIDCR: Domingo, Demetrio
NIMH: Swedo, Susan
NIDDK: Kopp, Jeffrey
Georgetown University Medical Center: Lacbawan, Felicitas
Uniformed Services University of Health Sciences: Sharp, Stephen
Johns Hopkins University: Bengel, Frank M.
Sensitivity and resistance to Rituximab therapy in SLL/CLL: the role of antigenic modulation, immune effector mechanisms and direct pro-apoptotic signaling NHLBI: Weistner, Adrian
NCI: Wilson, Wyndham
University of Virginia: Weiss, Geoffrey; Taylor, Ron
Quantification of urinary oxidized lipids, 8-hydroxyguanine, and 8-hydroxy-2'-deoxyguanosine in Friedreich ataxia patients undergoing idebenone treatment in a phase II double-blind placebo-controlled study NINDS: Fischbeck, Kenneth; DiProspero, Nicholas
University of Pennsylvania: Blair, Ian; Wilson, Robert
Translational Studies of Hereditary Spastic Paraplegias types SPG4 and SPG20 NINDS: Blackstone, Craig; Bakawska, Joanna
NIDDK: Hurley, James; Yang, Dong
Genetics of inherited paragangliomas and gastric stromal tumors associated with adrenal and other tumors NICHD: Stratakis, Constantine
Cleveland Clinic Genomics Medicine Institute: Eng, Charis

MINORITY HEALTH & HEALTH DISPARITIES CATEGORY

Project Institute or institution/Investigators
Effects of Beta Cell Rest in Young Individuals with Type 2 Diabetes and in Relevant Animal Model NIDDK: Rother, Kristina; Brown, Rebecca
UCLA: Butler, Peter
Identification of Predictive Biomarkers of Asthma Exacerbations in Exhaled Breath Condensates from High Risk Patients NHLBI: Levine, Stewart; Kaler, Maryann
Johns Hopkins University: Jackman, Joany; Rothman, Richard
Ethnic Differences in Triglyceride Levels and Vascular Disease: A Study of Premenopausal African American and Caucasian Women NIDDK: Sumner, Anne; Ricks, Madia
NHLBI: Sachdev, Vandana
CC: Denkinger, Blakeley
Harvard School of Public Health: Sacks, Frank
Brigham & Women's Hospital: Aikawa, Masanori
Contribution of Stromal Free Hemoglobin, Red Cell Membranes, and Red Cell Lysate on Nitric Oxide Inactivation in the Chronic Hemolytic State NHLBI: Gladwin, Mark; Machado, Roberto
CC: Solomon, Steven; Klein, Harvey; Natanson, Charles

WOMEN'S HEALTH CATEGORY

Project Institute or institution/Investigators
Targeting HPV E2 as a vaccine against HPV mediated CIN1 and CIN2 NCI: Khleif, Samir; Berzofsky, Jay; Qian, Jiahua
Gynecologic Oncology Group: Vaccine Working Group, Vaccine Subcommitte, GOG
University of Miami: Lucci, Joseph
University of Oklahoma: Walker, Joan

Previous Awards Funded

2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999

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