Clinical Center News
Fall 2022

Holland presents 2022 Astute Clinician Lecture

Addresses role of anticytokine autoantibodies

2022 Astute Clinician Lecture - Anticytokine Autoantibodies: Causes, Concomitants and Complications of Infectious Diseases, Presented by Steven M. Holland on November 2, 2022, 2-3pm at the Lipsett Amphitheature
Anticytokine Autoantibodies: Causes, Concomitants and Complications of Infectious Diseases.

Dr. Steven Holland gave the Astute Clinician Lecture as a part of the NIH Director's Wednesday Afternoon Lecture Series on November 2 by NIH Videocast. He presented "Anticytokine Autoantibodies: Causes, Concomitants and Complications of Infectious Diseases." Holland's lecture marked the 25th anniversary milestone for the Astute Clinician Lecture Series.

Holland is an NIH Distinguished Investigator, NIAID Scientific Director and Chief of the Immunopathogenesis Section. The Section uses a bench-to-bedside model for a fully integrated approach to infectious disease – incorporating the molecular genetics of the host and the pathogen as well as mechanisms of pathogenesis, together with clinical appreciation and investigation – to gain new insights into both mechanisms of action and avenues of therapy.

Holland earned his MD from Johns Hopkins University where he remained for his internal medicine residency, chief residency and fellowship in infectious diseases. He came to NIAID as a National Research Council fellow in 1989 with the Laboratory of Molecular Microbiology, working on transcriptional regulation of HIV. In 1992, he joined the newly formed Laboratory of Host Defenses, shifting his research to the host side, with a focus on phagocyte defects and their associated infections. His work centered on the pathogenesis and management of chronic granulomatous disease, as well as other congenital immune defects affecting phagocytes, including those predisposing to mycobacterial diseases. Holland became Scientific Director for NIAID's Division of Intramural Research in 2016.

The Astute Clinician Lecture was established in 1998 through a gift from the late Dr. Robert W. Miller and his wife, Haruko. The lecture honors U.S. scientists who have observed unusual clinical occurrences and, by investigating them, have opened an important new avenue of research. Learn more.

Watch the lecture

You are now leaving the NIH Clinical Center website.

This external link is provided for your convenience to offer additional information. The NIH Clinical Center is not responsible for the availability, content or accuracy of this external site.

The NIH Clinical Center does not endorse, authorize or guarantee the sponsors, information, products or services described or offered at this external site. You will be subject to the destination site’s privacy policy if you follow this link.

More information about the NIH Clinical Center Privacy and Disclaimer policy is available at