Back to: Clinical Center Home Page
This file is provided for reference purposes only. It was current when it was produced, but it is no longer maintained and may now be out of date. Persons with disabilities having difficulty accessing information may contact us
for assistance. For reliable, current information on this and other health topics, we recommend consulting the NIH Clinical Center at http://www.cc.nih.gov/
monthly for CC employees by Clinical Center Communications
a diabetes cure
Research Training" course to begin soon
head of pain and symptom management
Labor partnership council
Directory" brings order to information
left to right, Larry Moses, Sue Ellen Frodigh, Ken Hines, Janet Lee,
and Angela Pickett of the Clinical Center's Cell Processing Section.
Isolating a diabetes
Cell Processing Section leads in islet cell isolation
The Clinical Center's
Department of Transfusion Medicine is once again at the forefront of exciting
new clinical research as its Cell Processing Section (CPS) prepares islet
cells for transplantation in an effort to cure diabetes.
made headlines last month when they reported successfully transplanting
insulin-producing islet cells into eight patients with diabetes, freeing
them from daily insulin shots. The CPS is working hand in hand with NIDDK
researcher Dr. David Harlan to replicate and improve upon the Canadians'
work here at the Clinical Center.
to Dr. Harlan, "Islet isolation is not simple. There are a lot of
variables to consider."
It all starts with
a donor pancreas. Islet cells are clustered in ducts deep within the organ
and make up only about 2 to 3 percent of its cellular mass. Extracting
the islets requires a 6-hour procedure and three CPS technologists working
simultaneously in a sterile environment.
In brief, fat is trimmed
off the pancreas, and an enzyme called collagenase is pumped into the
ducts. The enzyme digests away the connective tissue that comprises most
of the pancreas. To aid the breakdown process, the tissue is also placed
in a stainless steel chamber full of marbles and agitated back and forth.
As the islet cells
are released, they are further separated and washed. The result is a volume
of pure islet cells ready for transplantation into the patient's liver
via the portal vein. This will be done in the Diagnostic Radiology Department's
Special Procedures Lab. Once imbedded in the liver, the islet cells appear
to produce insulin in response to blood sugar levels, according to the
Canadian team's report.
Already skilled in
cell-processing techniques, CPS lead technologists Janet Lee and Ken Hines
visited experts at the University of Miami in early 1999 to learn the
basics of islet isolation. They carried their new knowledge back to the
Clinical Center, and set to work modifying their lab to do islet isolations
for Dr. Harlan's original protocol, which planned to test an antirejection
drug called anti-CD154. That study was shelved when the drug was found
to cause blood clots.
Dr. Harlan retooled
his approach to replicate the Canadian team's work, and Lee and Hines
recently visited the Canadians to see exactly how they do their isolations.
The CPS team has processed more than 20 pancreata so far, and they are
ready to move forward with a clinical application.
The cell processing
facility opened in 1997 with the goals of developing and improving procedures
for collecting, modifying, growing, and preserving human cellular components.
The facility was designed to meet the Food and Drug Administration's regulatory
requirements for a biologics production facility. A biologic is a treatment
derived from a living organism, for example, a vaccine. Islet cells fall
into this category.
process is very labor intensive, and one of our goals is to streamline
and automate parts of it," said CPS chief Dr. Elizabeth Read. She
also pointed out that each pancreas yields different amounts of islets.
Additional research goals include standardizing the "dose" of
islets and developing ways to predict the amount of insulin they might
produce once in the body.
Other CPS staff involved
in this work include section supervisor Charley Carter, Sue Ellen Frodigh,
Larry Moses, Chauha Pham, Angela Pickett, and Hoi May Wong. Three technologists
are on call 24 hours a day, because a pancreas can arrive at any time.
attention, and effort put together the islet isolation unit. They bring
a squared-away, regulatory mindset to the process that a clinician might
not have," said Dr. Harlan.
"Only eight patients
in the world have had this therapy work, and none of them have been in
the United States. It is still very experimental. NIH will be one of the
first institutions to try this therapy in humans," said Dr. Harlan.
His new protocol is in review. He hopes to study up to 20 patients. And
CPS will be with him every step of the way.
-by Sue Kendall
Research Training" course to begin soon
new course for clinical principal investigators, "Clinical Research
Training," will be offered Sept. 12 from 12 noon to 4 p.m. in Lipsett
This course was designed
to address one of the essential
standards recently approved by the NIH for performing clinical research.
All clinical principal investigators are required to take the course and
successfully complete a final exam. Former participants of the "Introduction
to the Principles and Practice of Clinical Research" and "Ethical
and Regulatory Aspects of Human Subjects Research" who have passed
both courses, as exhibited by successful completion of the final exam
given in each program, will not be required to take the course.
Course topics include:
and Ethical Perspectives," Ezekiel J. Emanuel, M.D., Ph.D., Chief,
Department of Clinical Bioethics, CC.
- "Roles and
Responsibilities of the Investigator," Gregory Curt, M.D., Clinical
- "Roles and
Responsibilities of the Institution," Alison Wichman, M.D.,
Deputy Director, Office of Human Subjects Research, OD.
Issues," Jay Siegel, M.D., Director, Therapeutics Research and
- "Clinical Investigators
and the Mass Media," Anne Thomas, Associate Director for Communications,
Enrollment in the initial
course offering will be limited to those individuals for whom it is required.
Registration begins on Aug. 1 and ends on Aug. 30.
The course will be
repeated Dec. 12.
of Pharmacology" course to begin soon
"Principles of Clinical Pharmacology Course," sponsored by the
Clinical Center, will begin Sept. 7. The course will be held Thursdays
from 6:30 p.m. to 8 p.m. in Lipsett Amphitheater, and runs through April
Topics include: pharmacokinetics;
drug metabolism and transport; assessment of drug effects; drug therapy
in special populations; and drug discovery and development.\
An outstanding faculty
has been assembled to present the lectures, including Dr. Carl Peck of
Georgetown University's Center for Drug Development Science, Dr. Jerry
Collins of the Food and Drug Administration, and the Clinical Center's
Dr. Arthur J. Atkinson, Jr., course director. Before coming to NIH, Dr.
Atkinson was at Northwestern University, where he directed the Clinical
Pharmacology Center, and at the Upjohn Company, where he was in charge
of clinical drug development programs.
This is the third year
that the course is being offered. Last year 305 students registered, and
there was considerable sustained enthusiasm for the course.
Registration is free
and open to all interested persons. Syllabus materials will be provided
for each lecture. Certificates will be awarded at the end of the course
to students who attend 75 percent of the lectures.
and soda cans are but two of the many items that can be recycled
at NIH. Kenny Floyd, left, chief of the Waste Management Section,
and Dave Crook, right, NIH recycling coordinator, encourage you
to get involved and help set up a recycling effort in your work
area, if none currently exists.
NIH recycling website (http://www.nih.gov/od/ors/ds/
recycle/) provides threefold advice: (1) reduce the amount of materials
we consume, (2) reuse materials, and (3) recycle if possible.
individual actions can flesh out this advice. The Natural Resources
Defense Council (http://www.nrdc.org) lists the following ways that
individuals can help reduce garbage:
products made with recycled content and packaged in recyclable
goods in returnable and recyclable containers.
where you can take items to be recycled and make the effort to
out your community's waste management strategy, and encourage
local officials to consider more ambitious recycling initiatives.
about and avoid products that contain potentially hazardous contents.
your own (cloth) bags to local stores, and encourage others to
do the same.
store managers and manufacturers who are making good environmental
choices that you recognize and appreciate their efforts.
the introduction of and participate in bulk buying programs whereby
you can purchase larger quantities with less packaging.
the consumer hotlines provided by many companies to explain to
them the need for less packaging.
you among the folks who thought "Clean Your Files Week" (April
17-21) was a good idea but did not quite get around to it then? Perhaps
you were confused because your office did not have bins for recycling
either white office or mixed paper. You are not alone.
has grown at NIH since the mid-1980's, and paper recycling was high during
the recent "Clean Your Files Week," there is room for improvement,
said David Crook, recycling coordinator in the Environmental Protection
Branch, Division of Safety, ORS.
According to Crook
and William (Kenny) Floyd, chief, EPB Waste Management Section, the amount
of waste generated in Bldg. 10 alone is about one quarter of the campus
total (3,203 of 11,500 tons last year). The CC currently recycles 28 percent
of its wastes, and NIH, about 30 percent.
Could we do better?
The official recycling goal is 50 percent in Montgomery County, Md., where
NIH is located, and the county itself recycled 36 percent last year.
The Montgomery County
recycling regulation says that businesses, including government facilities,
must recycle office paper, corrugated cardboard, newsprint, aluminum and
bi-metal food and beverage cans, glass and plastic food and beverage containers,
and yard trimmings.
Businesses can voluntarily
recycle scrap metal, plastic film, food waste, wood waste, batteries,
motor oil and antifreeze, construction and demolition debris, toner cartridges,
and phone books.
But how? Crook works
with each NIH building or cluster to devise a recycling plan. Volunteer
area coordinators help by determining which categories each office, corridor,
or complex is willing to recycle and by calling Crook to arrange for containers
or for troubleshooting.
In a typical week in
early spring 2000, the CC generated 2.8 tons of recyclables in a campuswide
total of 12.1 tons. Crook emphasizes that the main goal of recycling is
to reduce the amount of waste going to landfills. The fact that recycling
also reduces the cost of waste disposal (about $44 per ton) is a bonus.
The 1999 bonus was $125,000 for 2,842 tons that NIH recycled in a year.
Aluminum is the clear
winner when it comes to the value of recycling-both for cash payback and
environmental value. Scrap metal dealers this spring were paying nearly
$640 per ton. Every ton recycled is one less ton to be imported: the United
States no longer mines any aluminum and must import all of it.
The per-ton payback
recently for some other wastes was $120 for office paper; $30 for cardboard;
and $10 for scrap metal. The NIH waste contractor looks for the best price
when hauling the recyclables to local dealers.
How could the CC do
more to reduce waste? Crook says, "If you could get all that mixed
paper out of the trash, it would make a huge difference." Many papers
listed as "don'ts" on the white office paper recycling containers
are eligible for recycling in the mixed paper containers.
Rental buildings in
Montgomery County, such as on Executive Boulevard where many CC off-campus
employees work, are required to make collection and storage of recyclables
available, if requested, to tenants. But a county brochure notes, "The
responsibility for participating and reporting, however, falls to the
individual business (already defined as including government facilities)
generating the waste materials."
To learn more about
NIH recycling or to request supplies, visit the recycling website http://www.nih.gov/od/ors/ds/recycle/.
If you cannot find a volunteer area coordinator listed for your area,
Crook points out, "A sign-up form is always available on the website!"
Or you can call him at 2-6036.
-by Linda Silversmith
head of pain and symptom management
Ann Berger joins the staff of the Clinical Center on Aug. 1. She will
set up and head a new Pain and Symptom Management Service, which will
help manage pain as well as other symptoms that make patients physically
uncomfortable, such as difficulty breathing, nausea and vomiting, and
"I am quite excited
about coming to the Clinical Center," said Dr. Berger. "Clearly
NIH is ready for pain and palliative care. I am anxious to start the service
as well as educational programs in pain and palliative care, and also
to have national input into this issue."
Dr. Berger earned a
B.S. degree in nursing from New York University and an M.S.N. degree in
oncology nursing from the University of Pennsylvania. After working as
an oncology clinical nurse specialist for several years, Dr. Berger completed
her medical training at the Medical College of Ohio, in Toledo. She completed
an internship and residency at Hartford Hospital in Connecticut, and went
on to Yale University for a fellowship in medical oncology and pain and
palliative care. She stayed on the faculty at Yale, where she started
a palliative care service. She achieved the rank of assistant professor
in medicine and anesthesiology.
Dr. Berger comes to
the CC from Cooper Hospital/University Medical Center, in Camden, N.J.,
where she is director of supportive care services. She is actively involved
in the care of patients as well as in education and research. She teaches
a palliative care course to medical students, residents, and fellows,
and chairs the ethics committee.
Nationally, Dr. Berger
is the leader for supportive care research in the Cancer Control Committee
in Cancer and Leukemia Group Board, chair of the CME committee for the
Academy of Hospice and Palliative Care, and is involved in many professional
societies. She has lectured extensively on pain and palliative care and
has published many articles in the field. She is senior editor of a major
textbook in palliative care, "Principles and Practice of Supportive
"We are delighted
to have Dr. Berger join our staff," said CC Director Dr. John Gallin.
"Her expertise in pain and palliative care will provide the leadership
that is crucial to the success of this new program."
Labor partnership council
and management relations just aren't what they used to beat least at NIH
they aren't. Thanks to the NIH Partnership Council, union leaders and
NIH management can proactively look at issues or concerns that the organization
at large faces, before they become serious problems. And by employing
techniques that "loosen" some of the traditional bargaining
rules to form a common understanding as to how things can be done to benefit
workers and managers alike, collaboration has truly taken on a new meaning.
Established in 1993,
the NIH Partnership Council promotes the objectives set forth in the President's
Executive Order 12871, which called for a change in the nature of relationships
between labor unions and management. Specifically, the NIH Partnership
Council is charged with identifying issues with agency-wide impact and
developing recommendations and/or solutions.
"The Council is
dedicated to supporting and facilitating the NIH's mission of the pursuit
and promotion of beneficial research through the practice of constructive,
interest-based bargaining between labor unions and NIH management,"
says Maria Gorrasi, the NIH labor relations specialist. "Council
members are encouraged to engage in a free flow of all information that
is relevant to the labor issues under consideration. This has helped to
foster mutual respect and understanding of all opinions and ideas."
Areas of interest to
the group are diverse, from transportation and parking on campus to daycare
and quality of worklife concerns. The group tackles these concerns as
they relate to the entire NIH community. The Clinical Center, in particular,
has representation that can bring to the table issues that will potentially
affect the entire NIH community.
at the CC is limited to the Nutrition and Housekeeping and Fabric Care
departments, who look to this group as an excellent way to bring unions
and managers together. "The more that people learn about this organization
and the value that it can bring to employees and managers, the more exciting
it is," said Alberta Bourn, chief of the Nutrition Department, and
alternate CC representative for the Council. "The group stands poised
to address a broad base of concerns."
The Council meets on
the first Tuesday of every month. Members and their alternates comprise
an equal number of union and management representatives. The four unions
represented to date on this Council are: American Federation of Government
Employees (AFGE) Local 2429; Washington Area Metal Trade Council (WAMTC);
Local F-271 International Association of Firefighters (IAAF); and the
Fraternal Order of Police (FOP) Lodge #1. One member from each of the
four union locals is appointed; four members from management are determined
by the NIH collective bargaining official; and one member is chosen by
the Federal Managers Association.
Meetings are open to
visitors, and a website will be launched soon. For more information, contact
-by LaTonya Kittles
Directory" brings order to information
employees who move or transfer need to update information in at least
one printed and two online directories. Didn't know that? Most people
don't. That's why the information is often wrong.
Meet NED, NIH Enterprise
Directory. It's a new system that automatically and simultaneously updates
information for you.
NED is like a well-organized
butler or mother. NED actually is a secure, centralized electronic directory-which
a technical committee recommended 4 years ago-to coordinate directories
for e-mail, personnel, parking, and more.
A specialized data
base, NED will store locator information for NIH staff, fellows, guests,
contractors, volunteers, and tenants (such as CBER employees) and link
with other NIH data bases and applications to share information and reduce
NED will assign each
individual a unique identifier, different from social security numbers,
that will then be used by all the linked systems. One result is no more
writer's cramp for new workers, who will no longer have to fill out multiple
forms with the same information. NED also will make checkout easier for
folks leaving NIH by identifying all associated resources, such as ID
badges, computer accounts, and keys. Other uses include access to TRANSHARE
for transportation assistance, card key access, library cards, and training.
The first step in getting
information into NED is to import it from existing data bases, such as
human resources, fellowship payment, telecommunications, Fogarty International
Center, parking and ID's, the e-mail directory, and ITAS (the integrated
time and attendance system). Next, administrative officers (AO's) will
become the registrars or gatekeepers, adding new workers, entering updates,
and de-registering departing workers.
Your AO is the person
to see if you have questions about whether your information is accurate
and current. CIT is offering 3-hour NED training courses to AO's and technicians.
Each institute and
center has a coordinator and a cut-over date. The CC coordinator is Elaine
Ayres, deputy chief operating officer, assisted by Ann Ellis, facility
management AO. The CC cut-over date was June 30.
Ellis emphasizes, "NED will operate under strict privacy and disclosure
rules, with listed individuals having the right to access and amend their
listings." The access of AO's is limited to only the records of the
staff for which they are responsible.
-by Linda Silversmith
The Friends of the
Clinical Center (FOCC) received a generous donation recently. Craig Widmaier,
left, of Becton Dickinson and Co., a medical supply company, presents
FOCC President Maria Stagnitto with a check for $5000 to benefit the NIH
charity that financially assists Clinical Center patients.
17 marks the debut of the "CRIS Educational Series." Developed
by the CC Information Systems Department, the series will provide opportunities
for CC and NIH personnel to learn about the selection process for a replacement
for the aged Medical Information System, or MIS. The new system will be
called the Clinical Research Information System, or CRIS.
Topics will include:
the electronic patient record; what's currently being marketed commercially
for health care information technology; how information technology can
be used in a research medical center; and other topics relevant to the
selection of a replacement system.
The first session is
July 17 from 2 p.m. to 4 p.m., in Lipsett Amphitheater. The topic is "Overview
of the Computer-Based Patient Record (CPR)," presented by Dr. Marshall
The remaining sessions
will take place from 11 a.m.-1 p.m. in Lipsett Amphitheater:
- Aug. 9, "Session
II: Status of Sites, Technology and Trends, and Vendors and Product
- Aug. 16, "Session
III: Medical Terminologies, Data Dictionaries, and Medical Knowledge
- Aug. 23, "Session
IV: Implementing a CPR: Success Strategies and Pitfalls to Avoid.
- Aug. 30, "Session
V: Historical Data Repository for Research and Outcome Analysis (Data
All are welcome to
attend. There is no fee or registration requirement. Contact Rubi Defensor
at 5-8516 for more information.
NIH general parking
permits for campus employees whose last names begin with M or N will expire
on the last day of July. To renew yours, visit the NIH Parking Office
in Bldg. 31, Room B3B04, weekdays between 7:30 a.m. and 4:30 p.m. Be sure
to bring your valid NIH identification card, driver's license, and valid
vehicle registration certificate for each vehicle to be registered.
Jaw pain study
NIDCR researchers seek
patients for studies of pain-relief medications. Patients with early-stage
temporomandibular disorders (TMD) will receive either the study drug,
celecoxib, a standard treatment drug, naproxen, or a placebo. Patients
with later-stage TMD will receive either the study drug etanercept or
a placebo. If you are between the ages of 18 and 65 and have TMD jaw pain,
call 1-800-411-1222 to find out if you might be eligible. There is no
charge to take part.
NIMH researchers seek
children ages 613 years for a study of how the brain controls finger
movements. Children may be healthy volunteers or those with a diagnosis
of Attention Deficit and Hyperactivity Disorder (ADHD). The study takes
3 hours and involves a neurological examination, ADHD assessment, and
noninvasive tests. Compensation provided. Call Dr. Marjorie Garvey at
6-5323 for details.
The Clinical Brain
Disorders Branch of NIMH is looking for normal volunteer college-educated
men between the ages of 30 and 50 for a 2-day outpatient study of variables
that might be related to the cause of schizophrenia. No overnight stay
is required. The study includes MRI, neurocognitive testing, and a neurological
examination. A stipend is available. Call Kayleen Hadd at 1-888-674-6464
for more information.
In case you haven't
noticed or visited lately, the Clinical Center's website has a new look.
It's also been reorganized to make information easier to find. New features
include "Research Today," which focuses on interesting aspects
of CC research, and "Staff Shortcuts" to frequently needed sites.
Feedback is welcome. Check it out at http://www.cc.nih.gov.
The 14th annual NIH
Research Festival will be held Oct. 1013. Poster abstracts are now
being accepted. Posters in any area of research conducted on campus will
be considered for presentation, but the organizing committee requests
only one poster submission per first author. The deadline for online poster
registration is 5 p.m., Aug. 7. For details, consult the website at http://festival2000.nih.gov,
or call Paula Cohen at 6-1776, or e-mail, email@example.com.
Doctors at NIH seek
adults with Sjögren's syndrome for research studies to improve understanding
and treatment of the disease. Participants receive study-related diagnosis,
evaluation, and medication at no charge. Please call for more information
about taking part: 1-800-411-1222.
NEI researchers seek
adults and children diagnosed with uveitis for research studies to help
find ways to improve diagnosis and treatment of this eye disease. Please
call 1-800-411-1222 for details.
CC Task Force wins
"Best Practices" Award
The CC Chemotherapy
Errors Prevention Task Force received one of six American Society of Health
Pharmacists Best Practices in Health-System Pharmacy Management Awards
for their submission, "An Interdisciplinary Continuous Improvement Approach
to Reducing Chemotherapy-related Medication Errors." This award honors
innovation and outstanding leadership in health-system pharmacy practice
management and pharmaceutical care. Members of this task force included:
Charles Daniels, PhD, Robert Dechristoforo, MS, Barry Goldspiel, PharmD,
David Kohler, PharmD, (Pharmacy Department); David Henderson, MD, Laura
Lee, RN (CC Office of the Director); Laura Chisholm, RN, Priscella Rivera,
RN (Nursing Department); Linda Berry, RN, Greg Hinson, RPh, Lillian Butler,
RN (Information Systems Department); Frank Balis, MD, Greg Curt, MD, and
Wyndham Wilson, MD PhD (National Cancer Institute).
| Editor: Sue
|| Staff Writers: LaTonya Kittles, Linda Silversmith
Center News, 6100 Executive Blvd., Suite 3C01, MSC 7511, National Institutes
of Health, Bethesda, MD 20892-7511. Tel: 301-496-2563. Fax: 301-402-2984.
Published monthly for CC employees by the Office of Clinical Center Communications,
Colleen Henrichsen, chief. News, article ideas, calendar events, letters,
and photographs are welcome. Deadline for submissions is the second Monday
of each month.
The information on this page is archived and provided for reference purposes only.
This page last reviewed on 09/9/09