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The Prevention of Cervical Cancer by
Vaccination and Other Means

Douglas Lowy, M.D.
Chief, Laboratory of Cellular Oncology
Center for Cancer Research
National Cancer Institute

October 9, 2007
Photo of Steven M. Holland

Dr. Douglas R. Lowy is chief of the Laboratory of Cellular Oncology in the Center for Cancer Research at the National Cancer Institute. He is also a deputy director of the Center for Cancer Research.

His research includes papillomaviruses and the regulation of normal and neoplastic growth. In the 1980s, he studied the genetic organization of papillomaviruses and identified the three viral papillomavirus oncogenes. More recently, he has worked on papillomavirus vaccines and the papillomavirus life cycle with his long-time collaborator Dr. John Schiller, NCI. His laboratory was involved in the initial development, characterization, and clinical testing of virus-like particle based vaccines. His work examining ways to boost the body's immune response to prevent cancer-causing infection with the human papillomavirus led to the development of the technology on which the HPV vaccine is based.

Dr. Lowy received his medical degree from New York University School of Medicine in 1968, and trained in internal medicine at Stanford University and dermatology at Yale University. Between 1970 and 1973, he was a research associate in the Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases. He returned to NIH in 1975 to start his laboratory at NCI.

Together with Schiller, Lowy in 2007 was named the Federal Employee of the Year and received the American Medical Association Nathan Davis Award for outstanding government service, an NIH Director’s Award, and the Novartis Clinical Immunology Prize. He is a member of the National Academy of Sciences Institute of Medicine.

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