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Good Pain, Bad Pain:
New Advances in Pain Mechanisms and Treatments

Michael J. Iadarola, Ph.D.
Chief, Neurobiology and Pain Therapeutics Section
Laboratory of Sensory Biology
National Institute of Dental and Craniofacial Research
National Institutes of Health

Tuesday, October 30, 2007
Photo of Steven M. Holland

Dr. Michael J. Iadarola graduated from American University and obtained a Ph.D. in pharmacology from Georgetown University. Postdoctoral studies in neuroscience followed at Duke University.

Dr. Iadarola investigates the molecular and physiological mechanisms of pain transmission and control. His research has identified the mechanisms governing changes in gene regulation due to persistent pain and clarified the process of pain transmission. He and colleagues discovered a way to permanently remove a pain-sensing neuron that forms a critical first link in the pain transmission pathway. This discovery has formed the basis for a new treatment initiative for intractable pain in patients with advanced cancer.

He first came to NIH in 1982 as a pharmacology research associate of the National Institute of General Medical Sciences and worked in the Laboratory of Preclinical Pharmacology, National Institute of Mental Health. He then completed a fellowship at the National Institute of Dental and Craniofacial Research, and became a research pharmacologist in the Neural Mechanisms and Tissue Injury Section. He has held his current position since 1996.

Dr. Iadarola has received two NIH Bedside-to-Bench Awards. He has also received two years of research funding through an externally reviewed intramural NIDCR competitive award program. A member of the Society for Neuroscience and the American Pain Society, Dr. Iadarola is active on NIH and external committees and as a reviewer. He has published widely in peer-reviewed journals.

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