Portrait of Harvey Klein

Harvey G. Klein, MD
Department of Transfusion Medicine


Academic Degrees
AB, Harvard College
MD, John Hopkins School of Medicine

Email: hklein@mail.cc.nih.gov

Phone: 301-496-9702

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NIH Clinical Center Senior Staff

Harvey G. Klein, MD


Harvey G. Klein graduated magna cum laude from Harvard College and earned his medical degree from Johns Hopkins School of Medicine. After an internship, residency and fellowship in hematology at Hopkins, Dr. Klein came to the National Institutes of Health in 1973, becoming chief of the Clinical Center's Department of Transfusion Medicine in 1984. He maintains his ties with Hopkins as a visiting professor in pathology and medicine.

Dr. Klein is known nationally and internationally for his expertise in blood transfusion. He is widely published on such topics as transfusion-transmitted disease, the management of immunosuppressive effects of blood transfusion, blood storage, and the impact of biotechnology on transfusion medicine. He co-authored the eleventh edition of Mollison's textbook, Blood Transfusion in Clinical Medicine, and has held editorial roles with several publications, including Blood, Transfusion, Transfusion Medicine Reviews, and the Journal of Clinical Apheresis.

Dr. Klein has an extensive list of professional activities that includes serving on the Institute of Medicine Blood Safety Forum, the Secretary's Advisory Committee on Blood Safety and Availability, the WHO Committee on Standardization and the FDA Blood Products Advisory Committee; chairing the US Pharmacopoeia Blood and Blood Products Committee and the American Red Cross Medical Advisory Committee; and serving as president of the American Association of Blood Banks and the National Marrow Donor Program Council.

Selected Honors and Awards

American Medical Writers Association – Medical Textbook Award, 2006; Emily Cooley Award of the American Association of Blood Banks, 2001; NIH Director's Award, 2000, 2014; HHS Secretary's Distinguished Services Award, 2000; Cohn de Laval Medal, World Apheresis Association, 1996; Allen Latham Award, European Society for Haemapheresis, 1995; John B. Alsever Award for contributions to the blood banking sciences, 1993; NIH Clinical Center Director's Award, 1992; meritorious service medal, Public Health Service, 1989; PHS Equal Opportunity Achievement Award, 1985; PHS commendation medal, 1980.

Selected Publications


Klein HG and Anstee DJ. Mollison's Blood Transfusion in Clinical Medicine. 12th Edition.Blackwell, London, 2014


Khuu, H, Klein HG. Donor lymphocyte infusion: transfusion immunotherapy following allogeneic hematopoietic transplantation. In: Mintz PD (ed) Transfusion Therapy: Clinical Principles and Practice. AABB Press, Bethesda 2011, pp.559-72.

Alvandi F, Klein HG. Blood Transfusion. In Clinical Hematology , Young NS, Gerson SL, High KA (editors). 2nd edition Elsevier, Philadelphia, 2010 p316-49.

Borge D, Klein HG. Cellular Gene Therapy. In: McLeod BC (ed) Apheresis: Principles and Practice 2nd Ed AABB Press, Bethesda MD 2010, pp. 636-49.

Lazarus EF, Klein HG. Hemapheresis and cellular therapy. In: Hoffman R. Benz EJ, Shattil S, Furie B, Cohen HJ, Silberstein LE, McGlave P (eds): Hematology: Principles and Practice. Churchill Livingstone Inc.: New York 2008, p2257-66.

Bolan CD, Klein HG. Blood components and pharmacologic aspects of hemostasis. In Kitchens CS, Kessler CM, Konkle BA (eds): Consultative Hemostasis and Thrombosis. 3rd ed. W.B. Saunders Company, New York, 2013 pp 496-525.

Griffith L, Klein HG. Immunohematology, In: Rich RR, Fleisher TA, Kotzin B, Shearer WT, Schroeder H (eds): Clinical Immunology: Principles and Practice. Churchill Livingstone, London 2001, p127.1-127.10.

Klein HG and Higgins MJ. Use of Blood components in the Intensive care Unit. In:Parrillo JE and Dellinger RP, (eds); Critical care Medicine. Mosby, Philadelphia 2001, p1416-1438.

Conry-Cantilena, Klein, HG. Hemochromatosis subjects as blood and tissue donors.In: Barton JC and Edwards CO, (eds); Hemochromatosis. Cambridge University Press, Cambridge 2000: p564-73.

Klein HG. Continuing issues regarding transfusion and coagulation factor-acquired HIV infection. In: Pizzo PA, Wilfert CM (eds); Pediatric AIDS. (3rd Edition) Baltimore, Williams and Wilkins, 1998.

Klein HG. Immunohematology, In: Rich RR, Fleisher TA, Schwartz BD, Shearer WT, Strober W (eds): Clinical Immunology: Principles and Practice. Mosby, St. Louis 1995, p2220-2228.

Klein, HG. Immunohematology and Blood Transfusion. In Isselbacher KJ, Braunwald E, Wilson JD, Martin JB, Fauci AS, Kasper DL (eds): Harrison's Principles of Internal Medicine, McGraw-Hill Inc, New York l993: p 2377.


Wang D, Cortés-Puch I, Sun J, Solomon SB, Kanias T, Remy KE, Feng J, Alimchandani M, Quezado M, Helms C, Perlegas A, Gladwin MT, Kim-Shapiro DB, Klein HG, Natanson C. Transfusion of older stored blood worsens outcomes in canines depending on the presence and severity of pneumonia. Transfusion. 2014;54:1712-24.

Solomon SB, Wang D, Sun J, Kanias T, Feng J, Helms CC, Solomon MA, Alimchandani M, Quezado M, Gladwin MT, Kim-Shapiro DB, Klein HG, Natanson C. Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia. Blood. 2013;121:1663-72.

Deans KJ, Minneci PC, Klein HG, Natanson C. The relevance of practice misalignments to trials in transfusion medicine. Vox Sang 2010 99:16-23.

Alter HJ, Klein HG. The hazards of blood transfusion in historical perspective. Blood 2008;112(7):2617-2626.

Deola S, Panelli MC, Maric D, Dmitrieva N, Voss C, Stroncek DF, Klein HG, Wang E Marincola FM. Helper" B cells promote cytotoxic T cell survival and proliferation independently of antigen presentation through CD27-CD70 interactions. J. Immunol 2008; 180:1362-72.

Klein HG, Spahn DR, Carson JL. Red blood cell transfusion in clinical practice. Lancet 2007;370:415-426.

Alter HJ, Epstein JS, Swenson SG, Van Raden MA, Klein HG, Ward JW, Kaslow RA, Menitove JE, Sandler SG, Sayers MH, Hewlett IK, Chernoff AI. Prevalence of Human Immunodeficiency Virus Type 1 (HIV-l) p24 antigen in U.S. Blood Donor: Assessment of Efficacy for Blood Donor Screening. N Engl J Med l990, 323:l3l2-l7.

Leitman SF, Klein HG, Melpolder JJ, Shih JW, Read EJ, Harvarth L, Darr F, Foy JL, Alter HJ. Clinical implications of positive tests for antibodies to human immunodeficiency virus type 1 in asymptomatic blood donors. N Engl of Med l989; 32l:9l7-23.

Bracey A, Klein HG, Chambers S, Corash L. Simplified Selective Isolation of Young Red Cells for Chronic Transfusion Support. Blood l983; 6l:l068-l07l.

Klein HG, Garner RJ, Miller DM, Rosen SL, Statham NJ, Winslow RM. Automated partial exchange transfusion in sickle cell anemia. Transfusion. 1980;20:578-84.

Miller DM, Winslow RM, Klein HG, Wilson KC, Statham NJ, Brown FL, Fulmer J. Improved Exercise Performance after Exchange Transfusion in Subjects with Sickle Cell Anemia. Blood l980;56:ll27-32.

Klein HG, Aledort LM, Bouma BN., et al. A Cooperative Study for the Detection of the Carrier State of Classic Hemophilia. N Engl J Med l977; 296:959-962.

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