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Harvey G. Klein, MD

Harvey G. Klein, MD
Department of Transfusion Medicine

Academic Degrees
AB, Harvard College
MD, John Hopkins School of Medicine


Phone: 301-496-9702

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NIH Clinical Center Senior Staff

Harvey G. Klein, MD


Harvey G. Klein graduated magna cum laude from Harvard College and earned his medical degree from the Johns Hopkins School of Medicine. After an internship, residency and fellowship in hematology at Hopkins, Dr. Klein came to the National Institutes of Health in 1973, becoming chief of the Clinical Center's Department of Transfusion Medicine in 1984. He maintains his ties with Hopkins as a visiting professor in pathology and medicine.

Dr. Klein is known nationally and internationally for his expertise in blood transfusion. He is widely published on such topics as blood policy, transfusion-transmitted disease, blood storage, and the impact of biotechnology on transfusion medicine. He co-authored the twelfth edition of Mollison's textbook, Blood Transfusion in Clinical Medicine, and has held editorial roles with several publications, including Blood, Transfusion, Transfusion Medicine Reviews, and the Journal of Clinical Apheresis.

Dr. Klein has an extensive list of professional activities that includes serving on the Institute of Medicine Blood Safety Forum, the Secretary's Advisory Committee on Blood Safety and Availability, the WHO Committee on Biologicals Standardization, the FDA Blood Products Advisory Committee, and the UK Research Review Committee for Blood and Transplantation; chairing the US Pharmacopoeia Blood and Blood Products Committee and the American Red Cross Medical Advisory Council; and serving as president of the American Association of Blood Banks and the National Marrow Donor Program Council.

Selected Honors and Awards

AABB Fantus Medal for Lifetime Achievements, 2017; Presidential Award of the International Society of Blood Transfusion, 2016; American Medical Writers Association – Medical Textbook Award, 2006; Emily Cooley Award of the American Association of Blood Banks, 2001; NIH Director's Award, 2000, 2014; HHS Secretary's Distinguished Services Award, 2000; Cohn de Laval Medal, World Apheresis Association, 1996; Allen Latham Award, European Society for Haemapheresis, 1995; NIH Clinical Center Director's Award, 1992; Meritorious Service Medal, Public Health Service, 1989; PHS Equal Opportunity Achievement Award, 1985; PHS Commendation Medal, 1980.

Selected Publications


Klein HG and Anstee DJ. Mollison's Blood Transfusion in Clinical Medicine. 12th Edition.Blackwell, London, 2014


Panch SR, Klein HG.  Hemapheresis.  In: Hoffman R. Benz, Silberstein LE, Heslop H, Weitz J,Anastasi J, Salama M, Abutalib S (eds):  Hematology: Principles and Practice, 7th Edition.  Elsevier :Philadelphia (2018) pp. 1781-91.

Klein HG. Blood Transfusion. In: Rodgers and Young (eds) The Bethesda Handbook of Clinical Hematology 3rd Edition. Lippincott Williams & Wilkins (2018). 

Murphy M, Klein HG. Blood Component and Pharmacologic Therapy for Hemostatic disorders. In: Kitchens, Kessler, Konkle (eds) Consultative Hemostasis and Thrombosis, Fourth edition. Elsevier (2018) 

Alvandi F, Klein HG. Blood Transfusion. In Clinical Hematology , Young NS, Gerson SL, High KA (editors). 2nd edition Elsevier, Philadelphia, 2010 p316-49. 

Griffith L, Klein HG. Immunohematology, In: Rich RR, Fleisher TA, Kotzin B, Shearer WT, Schroeder H (eds): Clinical Immunology: Principles and Practice. Churchill Livingstone, London 2001, p127.1-127.10. 

Klein HG. Immunohematology, In: Rich RR, Fleisher TA, Schwartz BD, Shearer WT, Strober W (eds): Clinical Immunology: Principles and Practice. Mosby, St. Louis 1995, p2220-2228. 

Klein, HG. Immunohematology and Blood Transfusion. In Isselbacher KJ, Braunwald E, Wilson JD, Martin JB, Fauci AS, Kasper DL (eds): Harrison's Principles of Internal Medicine, McGraw-Hill Inc, New York l993: p 2377.


Klein HG, Hrouda JC, Epstein JE. Sustainability of the United States Blood System. N Engl J Med 2017;377:1485-1488.

Suffredini D, Xu W, Sun J, et al. Parenteral Irons vs. Transfused Red Cells for Treatment of Anemia in a Canine Model of Pneumonia, Transfusion 2017;57(10):2338-2347. 

Klein HG. Blood Collection and Use in the United States: You Can’t Manage What You Can’t Measure. Transfusion 2016;56(9):2157-9. 

Solomon SB,Cortés-Puch I, Sun J, Remy KE, Wang D, Feng J, Khan SS, Sinchar D, Kim-Shapiro DB, Klein HG, Natanson C. Transfused Older Stored Red Blood Cells Improve the Clinical Course and Outcome in a Canine Lethal Hemorrhage/Reperfusion Model. Transfusion 2015; 55(11):2552-63. 

Klein HG, Flegel WA, Natanson C. Red Cell Transfusion: Precision versus Imprecision Medicine. JAMA. 2015;314(15):1557-8. 

Cortés-Puch I, Wang D, Sun J, Solomon SB, Remy KE, Fernandez M, Feng J, Kanias T, Bellavia L, Sinchar D, Perlegas A, Solomon MA, Kelley WE, Popovsky MA, Gladwin MT, Kim-Shapiro DB, Klein HG, Natanson C. Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia. Blood 2013;55(11):2552-63.

Solomon SB, Wang D, Sun J, Kanias T, Feng J, Helms CC, Solomon MA, Alimchandani M, Quezado M, Gladwin MT, Kim-Shapiro DB, Klein HG, Natanson C. Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia. Blood. 2013;121:1663-72.

Klein HG. Should Blood Be an Essential Medicine? N Engl J Med 2013;368 (3):199-201.

Alter HJ, Klein HG. The hazards of blood transfusion in historical perspective. Blood 2008;112(7):2617-2626.

Klein HG, Spahn DR, Carson JL. Red blood cell transfusion in clinical practice. Lancet 2007;370:415-426.

Leitman SF, Klein HG, Melpolder JJ, Shih JW, Read EJ, Harvarth L, Darr F, Foy JL, Alter HJ. Clinical implications of positive tests for antibodies to human immunodeficiency virus type 1 in asymptomatic blood donors. N Engl of Med l989; 32l:9l7-23.

Klein HG.  Transfusion Medicine:  The evolution of a new discipline.  JAMA l987: 258: 2l08-2l09.

Klein HG.  Blood Transfusion and Athletics; Games People Play.  New Engl J Med l985; 3l2:854-856.

Bracey A, Klein HG, Chambers S, Corash L. Simplified Selective Isolation of Young Red Cells for Chronic Transfusion Support. Blood l983; 6l:l068-l07l.

Klein HG, Garner RJ, Miller DM, Rosen SL, Statham NJ, Winslow RM. Automated partial exchange transfusion in sickle cell anemia. Transfusion. 1980;20:578-84.

Miller DM, Winslow RM, Klein HG, Wilson KC, Statham NJ, Brown FL, Fulmer J. Improved Exercise Performance after Exchange Transfusion in Subjects with Sickle Cell Anemia. Blood l980;56:ll27-32.

Klein HG, Aledort LM, Bouma BN., et al. A Cooperative Study for the Detection of the Carrier State of Classic Hemophilia. N Engl J Med l977; 296:959-962.

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This page last updated on 02/23/2018

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