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Course-Specific Elements


Principles of Clinical Pharmacology: Schedule/Syllabus

2007-2008 Course Schedule

All sessions will meet Thursday evenings from 6:30 p.m. to approximately 7:45 p.m. Eastern time in the NIH Clinical Center.

September 6

Introduction to course

Slides for 9/6/07 lecture PDF Logo

Video with caption Real Player Icon

 

J. Lertora

MODULE 1: PHARMACOKINETICS

September 13

Clinical pharmacokinetics

Slides for 9/13/07 lecture PDF Logo

Video with caption Real Player Icon

 J. Lertora

September 20

Compartmental analysis of drug distribution

Slides for 9/20/07 lecture PDF Logo

Video with caption Real Player Icon

J. Lertora

September 27

Drug absorption and bioavailability

Slides for 9/27/07 lecture PDF Logo

Video with caption Real Player Icon

J. Lertora

October 4

Effects of renal disease on pharmacokinetics

Supplemental Reading:
FDA Guidance for Industry: Pharmacokinetics in Patients with Impaired Renal Function –
Study Design, Data Analysis, and Impact on Dosing and Labeling.
http://www.fda.gov/cder/guidance/1449fnl.pdf PDF Logo

Journal article in Seminars in Dialysis – Vol 16, No 1 (January-February) 2003 pp 45-50. Article entitled,
The Effect of Chronic Renal Failure on Hepatic Drug Metabolism and Drug Disposition,
authors Albert W. Dreisbach and Juan J.L. Lertora.

Slides for 10/4/07 lecture PDF Logo

Video with caption Real Player Icon

J. Lertora

October 11

SPECIAL LECTURE: Pharmacokinetics in patients requiring renal replacement therapy

- Dr. Atkinson's slides PDF Logo
- Dr. Susla's slides PDF Logo

Video with caption Real Player Icon

A. Atkinson
G. Susla

October 18

Use of positron emission tomograpthy (PET) in pharmacokinetics

Slides for 10/18/07 lecture PDF Logo

Video with caption Real Player Icon

10/18/07 Lecture -Video 1 Real Player Icon
10/18/07 Lecture -Video 2  Real Player Icon

R. Innis

October 25

Effects of liver disease on pharmacokinetics

Slides for 10/25/07 lecture PDF Logo

Supplemental Reading:
FDA Guidance for Industry: Pharmacokinetics in Patients with Impaired Hepatic Function: Study Design, Data Analysis, and Impact on Dosing and Labeling.
http://www.fda.gov/cber/gdlns/imphep.pdf PDF Logo

Video with caption Real Player Icon

J. Lertora

November 1

Pathways of drug metabolism

Slides for 11/1/07 lecture PDF Logo

Video with caption Real Player Icon

S. Markey

November 8

Noncompartmental vs. compartmental approaches to PK analysis

Slides for 11/8/07 lecture PDF Logo

Video with caption Real Player Icon

D. Foster

November 15

Population pharmacokinetics

Slides for 11/15/07 lecture PDF Logo

Video with caption Real Player Icon

R. Miller

MODULE 2: DRUG METABOLISM AND TRANSPORT

November 29

Drug interactions

Slides for 11/29/07 lecture PDF Logo

Video with caption Real Player Icon

S. Penzak

December 6

Chemical assay of drugs and drug metabolites

Slides for 12/6/07 lecture PDF Logo

Video with caption Real Player Icon

S. Markey

December 13

Pharmacogenetics

Slides for 12/13/07 lecture PDF Logo

Video with caption Real Player Icon

D. Flockhart

December 20

Biochemical mechanisms of drug toxicity

Slides for 12/20/07 lecture PDF Logo

Video with caption Real Player Icon

L. Pohl

January 10

Equilibrative and concentrative transport

Slides for 1/10/08 lecture PDF Logo

Video with caption Real Player Icon

P. Preusch

January 17

SPECIAL LECTURE: P-glycoprotein and drug transport

Dr. Innis' Slides for 1/17/08 lecture PDF Logo
Dr. Gottesman's Slides for 1/17/08 lecture PDF Logo

Journal Article provided by Dr. Innis PDF Logo

Video with caption Real Player Icon

M. Gottesman
R. Innis

MODULE 3: ASSESSMENT OF DRUG EFFECTS:

January 24

Dose response and concentration response analysis

Slides for 1/24/08 lecture PDF Logo

Video with caption Real Player Icon

F. Balis

January 31

Physiological and laboratory markers of drug effect

Slides for 1/31/08 lecture (with space for notes) PDF Logo
Slides for 1/31/08 lecture (without space for notes) PDF Logo

Video with caption Real Player Icon

J. Woodcock

February 7

Disease progression models and clinical trial simulation

Slides for 2/7/08 lecture (with space for notes) PDF Logo
Slides for 2/7/08 lecture (without space for notes) PDF Logo

Video with caption Real Player Icon

D. Mould

MODULE 4: Optimizing and Evaluating Patient Therapy

February 14

Drug therapy in pregnant and nursing women

Slides for 2/14/08 lecture (with space for notes) PDF Logo
Slides for 2/14/08 lecture (without space for notes) PDF Logo

Video with caption Real Player Icon

M. Frederiksen

February 21

Developmental and pediatric pharmacology

Slides for 2/21/08 lecture (with space for notes) PDF Logo
Slides for 2/21/08 lecture (without space for notes)  PDF Logo

Video with caption Real Player Icon

F. Balis

February 28

Drug therapy in the elderly

Slides for 2/28/08 lecture (with space for notes) PDF Logo
Slides for 2/28/08 lecture (without space for notes)  PDF Logo

Video with caption Real Player Icon

D. Abernethy

March 6

Clinical analysis of adverse drug reactions

Slides for 3/6/08 lecture PDF Logo

Video with caption Real Player Icon

K. Calis

March 13

Quality assessment of drug therapy

Slides for 3/13/08 lecture PDF Logo

Video with caption Real Player Icon

C. Daniels

MODULE 5: DRUG DISCOVERY AND DEVELOPMENT

March 20

Drug discovery

Slides for 3/20/08 lecture PDF Logo

Video with caption Real Player Icon

E. Sausville

March 27

Pre-clinical drug development

Slides for 3/27/08 lecture PDF Icon

Video with caption Real Player Icon