NIH Clinical Center: Schedule/Syllabus

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Principles of Clinical Pharmacology: Schedule/Syllabus

2009-2010 Course Schedule

(18 KB)

All sessions will meet Thursday evenings from 6:30 p.m. to approximately 7:45 p.m. Eastern time in the NIH Clinical Center, Building 10, in the Lipsett Amphitheater in Bethesda, Maryland.

If you experience any accessibility problems with the PDFs below, please contact (301) 496-9425 or email CC-OD_Clinp@mail.cc.nih.gov

September 3	Introduction to course Introduction Slides (1 slide per page) (925 KB) Introduction Slides (3 slides per page) (290 KB) Introduction Slides (Text-Only) (151 KB) Video of Introduction to course from lecture with caption (Adobe Connect Link)	J. Lertora (NIH/CC)
MODULE 1: PHARMACOKINETICS
September 10	Clinical pharmacokinetics Clinical Pharmacokinetics Slides (1 slide per page) (975 KB) Clinical Pharmacokinetics Slides (3 slides per page) (333 KB) Clinical Pharmacokinetics Slides (Text-Only) (175 KB) Video of Clinical pharmacokinetics from lecture with caption (Adobe Connect Link)	J. Lertora (NIH/CC)
September 17	Chemical assay of drugs and drug metabolites Chemical Assay Slides (1 slide per page) (1.3 MB) Chemical Assay Slides (3 slides per page) (443 KB) Chemical Assay Slides (Text-Only) (250 KB) Video of Chemical assay of drugs and drug metabolites from previous year lecture with caption (Adobe Connect Link)	S. Markey (NIH/NIMH)
September 24	Compartmental analysis of drug distribution Compartmental analysis of drug distribution slides (1 slide per page) (20 MB) Compartmental analysis of drug distribution slides (3 slides per page) (732 KB) Compartmental analysis of drug distribution slides (Text-Only) (191 KB) Video of compartmental analysis of drug distribution with caption(Adobe Connect Link)	J. Lertora (NIH/CC)
October 1	Drug absorption and bioavailability Drug absorption and bioavailability slides (1 slide per page) (1.45 MB) Drug absorption and bioavailability slides (3 slides per page) (659 KB) Drug absorption and bioavailability slides (Text-Only) (177 KB)) Video of drug absorption and bioavailability with caption (Adobe Connect Link)	J. Lertora (NIH/CC)
October 8	Use of positron emission tomography (PET) in pharmacokinetics Positron Emission Tomography slides (1 slide per page) (1.26 MB) Positron Emission Tomography slides (3 slides per page) (792 KB) Positron Emission Tomography slides (Text-Only) (170 KB) Video of Positron emission tomography (PET) with caption (Adobe Connect Link) PET Lecture -Video 1 PET Lecture -Video 2	R. Innis (NIH/NIMH)
October 15	Effects of renal disease on pharmacokinetics Effects of renal disease on pharmacokinetics (1 slide per page) (744 KB) Effects of renal disease on pharmacokinetics (3 slides per page) (259 KB) Effects of renal disease on pharmacokinetics (Text-Only) (233 KB) Video of Effects of Renal Disease on Pharmacokinetics with caption (Adobe Connect Link)	J. Lertora (NIH/CC)
October 22	SPECIAL LECTURE: Pharmacokinetics in patients requiring renal replacement therapy Pharmacokinetics in patients requiring renal replacement therapy (Dr. Atkinsons's slides - 1 slide per page) (1,968 MB) Pharmacokinetics in patients requiring renal replacement therapy (Dr. Atkinsons's slides - 3 slides per page) (761 KB) Pharmacokinetics in patients requiring renal replacement therapy (Dr. Atkinsons's slides - Text-only) (176 KB) Pharmacokinetics in patients requiring renal replacement therapy (Dr. Susla's slides - 1 slide per page) (229 KB) Pharmacokinetics in patients requiring renal replacement therapy (Dr. Susla's slides - 3 slides per page) (95 KB) Pharmacokinetics in patients requiring renal replacement therapy (Dr. Susla's slides - Text-only) (152 KB) Video of pharmacokinetics in patients requiring hemodialysis Video with caption (Adobe Connect Link)	A. Atkinson (Northwestern University) G. Susla (MedImmune, Inc)
October 29	Noncompartmental vs. compartmental approaches to PK analysis Noncompartmental vs. compartmental approaches to PK analysis (1 slide per page) (1.2 MB) Noncompartmental vs. compartmental approaches to PK analysis (3 slides per page) (350 KB) Noncompartmental vs. compartmental approaches to PK analysis (Text-only) (126 KB) Video of noncompartmental vs. compartmental approaches to PK data analysis with caption	P. Vicini (Pfizer, Inc.)
November 5	Effects of liver disease on pharmacokinetics Effects of liver disease on pharmacokinetics (1 slide per page) (768 KB) Effects of liver disease on pharmacokinetics (3 slides per page) (272 KB) Effects of liver disease on pharmacokinetics (Text-only) (210 KB) Video of effects of liver disease on pharmacokinetics from previous year lecture video with caption	J. Lertora (NIH/CC)
November 12	Population pharmacokinetics Population pharmacokinetics from previous year (1 slide per page) (676 KB) Population pharmacokinetics from previous year (3 slides per page) (335 KB) Population pharmacokinetics from previous year (Text-only) (167 KB) Video of population pharmacokinetics from previous year video with caption	R. Miller (Pfizer, Inc.)
MODULE 2: DRUG METABOLISM AND TRANSPORT
November 19	Pathways of drug metabolism Pathways of drug metabolism from previous year (1 slide per page) (1.24 MB) Pathways of drug metabolism from previous year (3 slides per page) (268 KB) Pathways of drug metabolism from previous year (Text-only) (159 KB) Video of pathways of drug metabolism from previous year lecture video with caption	S. Markey (NIH/NIMH)
December 3	Drug Interactions Drug Interactions (1 slide per page) (641 KB) Drug Interactions (3 slides per page) (328 KB) Drug Interactions (Text-only) (385 KB) Video of drug interactions from previous year lecture video with caption	S. Penzak (NIH/CC)
December 10	Pharmacogenomics Pharmacogenomics from previous year (1slide per page) (2.28 MB) Pharmacogenomics from previous year (3 slides per page) (637 KB) Pharmacogenomics from previous year (Text-only) (141 KB) Video of pharmacogenetics from previous year lecture video with caption	D. Flockhart (IUPUI)
December 17	Biochemical mechanisms of drug toxicity Biochemical mechanisms of drug toxicity from previous year (1 slide per page) (707 KB) Biochemical mechanisms of drug toxicity from previous year (3 slides per page) (231 KB) Biochemical mechanisms of drug toxicity from previous year (Text-only) (165 KB) Video of Biochemical mechanisms of drug toxicity from previous year lecture video with caption	L. Pohl (NIH/NHLBI)
January 7	SPECIAL LECTURE: P-glycoprotein and drug transport Dr. Gottesman: SPECIAL LECTURE: P-glycoprotein and drug transport from previous year (1 slide per page) (2.12 MB) Dr. Gottesman: SPECIAL LECTURE: P-glycoprotein and drug transport from previous year (3 slides per page) (781 KB) Dr. Gottesman: SPECIAL LECTURE: P-glycoprotein and drug transport from previous year (Text-only) (146 KB) Dr. Innis: SPECIAL LECTURE: P-glycoprotein and drug transport from previous year (1 slide per page) (1.45 MB) Dr. Innis: SPECIAL LECTURE: P-glycoprotein and drug transport from previous year (3 slides per page) (764 KB) Dr. Innis: SPECIAL LECTURE: P-glycoprotein and drug transport from previous year (Text-only) (134 KB) Video of P-glycoprotein and drug transport from previous year lecture video with caption	M. Gottesman (NIH/OIR) R. Innis (NIH/NIMH)
January 14	Equilibrative and concentrative transport Equilibrative and concentrative transport from previous year (1 slide per page) (3.66 MB) Equilibrative and concentrative transport from previous year (3 slides per page) (1.06 MB) Equilibrative and concentrative transport from previous year (Text-only) (283 KB) Video of Equilibrative and concentrative transport lecture video with caption	J. Ware (Genentech, Inc.)
MODULE 3: ASSESSMENT OF DRUG EFFECTS:
January 21	Disease progression models and clinical trial simulation Disease progression models and clinical trial simulation from previous year (1 slide per page) (1.4 MB) Disease progression models and clinical trial simulation from previous year (3 slides per page) (513 KB) Disease progression models and clinical trial simulation from previous year (Text-only) (252 KB) Video of disease progression models and clinical trial simulation from previous year lecture	D. Mould (Projections Research,Inc.)
January 28	Dose response and concentration response analysis Dose response and concentration response analysis from previous year (1 slide per page) (252 KB) Dose response and concentration response analysis from previous year (3 slides per page) (103 KB) Dose response and concentration response analysis from previous year (Text-only) (156 KB) Video of Dose response and concentration response analysis video with caption	J. Lertora (NIH/CC)
February 4	Physiological and laboratory markers of drug effect Physiological and laboratory markers of drug effect from previous year (1 slide per page) (87 KB) Physiological and laboratory markers of drug effect from previous year (3 slides per page)(66 KB) Physiological and laboratory markers of drug effect from previous year (Text-only) (176 KB) Video of physiological and laboratory markers of drug effect from previous year lecture video with caption	J. Woodcock (FDA/CDER)
MODULE 4: Optimizing and Evaluating Patient Therapy
February 11	Drug therapy in pregnant and nursing women Drug therapy in pregnant and nursing women from previous year (1 slide per page) (793 KB) Drug therapy in pregnant and nursing women from previous year (3 slides per page) (387 KB) Drug therapy in pregnant and nursing women from previous year (Text-only) (324 KB) Video of drug therapy in pregnant and nursing women from previous year lecture	M. Frederiksen (Northwestern University)
February 18	Developmental and pediatric pharmacology Developmental and pediatric pharmacology from previous year (1 slide per page) (316 KB) Developmental and pediatric pharmacology from previous year (3 slides per page) (204 KB) Developmental and pediatric pharmacology from previous year (Text-only) (259 KB) Video of developmental and pediatric pharmacology previous year lecture video with caption	J. van den Anker (Children's National Medical Center)
February 25	Drug therapy in the elderly Pharmacodynamics: Drug Therapy in the Elderly from previous year (1 slide per page) (3.74 MB) Pharmacodynamics: Drug Therapy in the Elderly from previous year (3 slides per page) (204 KB) Pharmacodynamics: Drug Therapy in the Elderly from previous year (Text-only) (259 KB) Video of drug therapy in the elderly previous year lecture video with caption	D. Abernethy (U.S. Pharmacopeia)
March 4	Quality assessment of drug therapy Quality assessment of drug therapy from previous year (1 slide per page) (497 KB) Quality assessment of drug therapy from previous year (3 slides per page) (276 KB) Quality assessment of drug therapy from previous year (Text-only) (161 KB) Video of quality assessment of drug therapy previous year lecture video with caption	C. Daniels (UCSD)
March 11	Clinical analysis of adverse drug reactions Clinical analysis of adverse drug reactions from previous year (1slide per page) (446 KB) Clinical analysis of adverse drug reactions from previous year (3 slides per page) (89) Clinical analysis of adverse drug reactions from previous year (Text-only) (177) Video of clinical analysis of adverse drug reactions previous year lecture video with caption	C. Chamberlain (NIH/CC)
MODULE 5: DRUG DISCOVERY AND DEVELOPMENT
March 18	Drug discovery Drug discovery from previous year (One slide per page) (3.2 MB) Drug discovery from previous year (Three slides per page) (978 KB) Drug discovery from previous year (Text-only) (409 KB) Video of drug discovery previous year lecture video with caption	E. Sausville (UMMS)
March 25	Pre-clinical drug development Pre-clinical drug development from previous year (One slide per page) (819 KB) Pre-clinical drug development from previous year (Three slides per page) (246 KB) Pre-clinical drug development from previous year (Text-only) (443 KB) Video of pre-clinical drug development previous year lecture video with caption	C. Takimoto (Centocor R&D, Inc., Johnson & Johnson)
April 1	Animal scale up and Phase I studies Dedrick: Animal scale up and Phase I studies from previous year (One slide per page) (1.37 MB) Dedrick: Animal scale up and Phase I studies from previous year (Three slides per page) (362 KB) Dedrick: Animal scale up and Phase I studies from previous year (Text-only) (76 KB) Collins: Animal scale up and Phase 1 studies from previous year (One slide per page) (760 KB) Collins: Animal scale up and Phase 1 studies from previous year (Three slides per page) (433 KB) Collins: Animal scale up and Phase 1 studies from previous year (Text-only) (181 KB) Dr. Dedrick's previous year lecture Video with caption Dr. Collins' previous year lecture Video with caption	R. Dedrick (NIH/NIBIB) J. Collins (NIH/NCI)
April 8	Role of the FDA in guiding drug development Role of the FDA in guiding drug development from previous year (One slide per page) (541 KB) Role of the FDA in guiding drug development from previous year (Three slides per page) (414 KB) Role of the FDA in guiding drug development from previous year (Text-only) (241 KB) Video of role of the FDA in guiding drug development from previous year lecture video with caption	C. Peck (CDDS, UCSF)
April 15	Design of clinical drug development programs Design of clinical drug development programs from previous year (One slide per page) (960 KB) Design of clinical drug development programs from previous year (Three slides per page) (414 KB) Design of clinical drug development programs from previous year (Text-only) (319 KB) Video of design of clinical drug development program with caption	C. Breder (FDA)
April 22	Pharmacokinetics of biotechnology products and large molecules Pharmacokinetics of biotechnology products and large molecules from previous year (One slide per page) (1.2 MB) Pharmacokinetics of biotechnology products and large molecules from previous year (Three slides per page) (679 KB) Pharmacokinetics of biotechnology products and large molecules from previous year (Text-only) (272 KB) Video of pharmacokinetics of biotechnology products and large molecules from previous year lecture video with caption	P. Garzone (PD3G Consulting)

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MODULE 1: PHARMACOKINETICS

MODULE 2: DRUG METABOLISM AND TRANSPORT

MODULE 3: ASSESSMENT OF DRUG EFFECTS:

MODULE 4: Optimizing and Evaluating Patient Therapy

MODULE 5: DRUG DISCOVERY AND DEVELOPMENT