| Programs and Services |
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All sessions will meet Thursday evenings from 6:30 p.m. to approximately 7:45 p.m. Eastern time in the NIH Clinical Center.
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September 6 |
Introduction to course |
J. Lertora |
MODULE 1: PHARMACOKINETICS | ||
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September 13 |
Clinical pharmacokinetics |
J. Lertora |
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September 20 |
Compartmental analysis of drug distribution |
J. Lertora |
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September 27 |
Drug absorption and bioavailability |
J. Lertora |
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October 4 |
Effects of renal disease on pharmacokinetics Supplemental Reading: |
J. Lertora |
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October 11 |
SPECIAL LECTURE: Pharmacokinetics in patients requiring renal replacement therapy - Dr. Atkinson's slides |
A. Atkinson |
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October 18 |
Use of positron emission tomograpthy (PET) in pharmacokinetics |
R. Innis |
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October 25 |
Effects of liver disease on pharmacokinetics Supplemental Reading: |
J. Lertora |
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November 1 |
Pathways of drug metabolism |
S. Markey |
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November 8 |
Noncompartmental vs. compartmental approaches to PK analysis |
D. Foster |
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November 15 |
Population pharmacokinetics |
R. Miller |
MODULE 2: DRUG METABOLISM AND TRANSPORT | ||
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November 29 |
Drug interactions |
S. Penzak |
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December 6 |
Chemical assay of drugs and drug metabolites |
S. Markey |
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December 13 |
Pharmacogenetics |
D. Flockhart |
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December 20 |
Biochemical mechanisms of drug toxicity |
L. Pohl |
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January 10 |
Equilibrative and concentrative transport |
P. Preusch |
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January 17 |
SPECIAL LECTURE: P-glycoprotein and drug transport Dr. Innis' Slides for 1/17/08 lecture |
M. Gottesman |
MODULE 3: ASSESSMENT OF DRUG EFFECTS: | ||
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January 24 |
Dose response and concentration response analysis |
F. Balis |
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January 31 |
Physiological and laboratory markers of drug effect Slides for 1/31/08 lecture (with space for notes) |
J. Woodcock |
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February 7 |
Disease progression models and clinical trial simulation Slides for 2/7/08 lecture (with space for notes) |
D. Mould |
MODULE 4: Optimizing and Evaluating Patient Therapy | ||
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February 14 |
Drug therapy in pregnant and nursing women Slides for 2/14/08 lecture (with space for notes) |
M. Frederiksen |
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February 21 |
Developmental and pediatric pharmacology Slides for 2/21/08 lecture (with space for notes) |
F. Balis |
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February 28 |
Drug therapy in the elderly Slides for 2/28/08 lecture (with space for notes) |
D. Abernethy |
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March 6 |
Clinical analysis of adverse drug reactions |
K. Calis |
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March 13 |
Quality assessment of drug therapy |
C. Daniels |
MODULE 5: DRUG DISCOVERY AND DEVELOPMENT | ||
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March 20 |
Drug discovery |
E. Sausville |
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March 27 |
Pre-clinical drug development | |
