David S. Goldstein, MD, PhD
Entry Id: TP-9

Overview
The Autonomic Disorders Section carries out mainly patient-oriented clinical research on the diagnosis, mechanisms and treatment of neurocardiologic disorders. We study catecholamine systems, focusing on biomarkers and mechanisms of Parkinson’s disease and related disorders. Measurement techniques include cardiovascular reflexes, neuropharmacologic manipulations, neurochemical assays, and positron emission tomographic imaging. The section runs a world-renowned Clinical Neurochemistry Laboratory.

Structure of the Clinical Training Program
The Autonomic Disorders Section, under the direction of Dr. David S. Goldstein, offers a clinical fellowship position in autonomic disorders. Dr. Goldstein has substantial experience in training and mentoring post-doctoral investigators in patient-oriented research about neurocardiologic disorders involving catecholamine systems. He is a recipient of the NIH Distinguished Clinical Teacher Award. The fellowship prepares participants to become independent clinicians and researchers in the areas of heart-brain medicine, clinical evaluation of disorders of catecholamine systems, and dysautonomias.

Examples of Papers Authored by Program Faculty

• Goldstein DS. Adrenaline and the Inner World: An Introduction to Scientific Integrative Medicine. Baltimore: Johns Hopkins University Press, 2006
• Goldstein DS. Catecholamines 101. Clin Auton Res 2010;20:331-352.
• Goldstein DS, Holmes C, Kopin IJ, Sharabi Y. Decreased vesicular uptake of neuronal catecholamines in patients with Lewy body diseases. J Clin Invest (in press).

Qualified candidates for a Clinical Fellowship position (with privileges in the NIH Clinical Center) should be licensed to practice medicine in the United States and have a serious interest in patient-oriented clinical research on one of the above scientific topics.

Qualified candidates for a Pre-Clinical Fellowship position should have an advanced degree in biochemistry, neurochemistry, physiology, or similar subject matter or have demonstrable skills in bench laboratory techniques relevant to the research of the Clinical Neurocardiology Section; and should have a serious interest in one of the above scientific topics.

The NIH is dedicated to building a diverse community in its training and employment programs.

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