Clinical Data Repository (CDR)

Protocol Specifications
National Institutes of Health
Warren G. Magnuson Clinical Center
Information Systems Department
Revised on June 11, 1999
Version 1.4


Protocol Information is provided on a daily basis from the Protocol Coordination Service Center, Medical Record Department and uploaded into the repository. Requests of this information must be approved from the Director, Medical Record Department.

Table: cc_protocol_info


Description: cc_protocol_info contains the main information related to a protocol.

Relationships:

1. cc_protocol_info has 0-multiple cc_protocol_inv_drugs.
2. cc_protocol_info has 0-multiple cc_protocol_inv_devices.
3. cc_protocol_info has 0-multiple cc_protocol_exclusions.
4. cc_protocol_info has 0-multiple cc_protocol_consents.
5. cc_protocol_info has 0-multiple cc_protocol_keywords.
6. cc_protocol_info has 0-multiple cc_protocol_pi_keywords.
7. cc_protocol_info has a principal investigator and an information contact whose biographical data are contained in cc_researcher_info.
8. cc_protocol_info has 0-multiple cc_protocol_alias_info.

Base NameAttribute Definition Column DatatypeAttribute Type
nih_protocol_idThe protocol number assigned by the Protocol Services Section, MRD. Number is year-institute-sequence number. varchar(20)Owned Key
protocol_idProtocol ID is year and sequence number. IE, the protocol id for protocol 96-C-0023 is 960023. intOwned Non-key
titleProtocol Titletext Owned Non-key
abbrv_titleAbbreviated Title/Short Title for protocol. varchar(30)Owned Non-key
principal_inv_idPrincipal Investigator ID.numeric(9) Foreign Non-key
info_contact_idInformation Contact ID. This field is used by the web pages to determine who requests for info should go to. Requests are filtered through CC Communications. numeric(9)Foreign Non-key
research_type Research Type indicates clinical versus screening. varchar(30)Owned Non-key
research_phase Research Phase for Protocol. Entries are I, II, III, IV or N/A. char(4) Owned Non-key
protocol_type Protocol Type. I.E. Active, Inactive Terminated, Active Follow-Up. char(30) Owned Non-key
initial_approval_date Initial Approval Date of protocol provided by OD, CC. datetime Owned Non-key
termination_date Date protcol was terminated. datetime Owned Non-key
precis Precis/Study summary for protocol. text Owned Non-key
hstat_access Identifies whether protocol can be made available to public protocol web site. If No, then pi was given approval by MRD Director to leave off system. char(3) Owned Non-key
gender Gender inclusions for protocol. Can be Male, Female, Male & Female. varchar(13) Owned Non-key
median_sub_age Age range in which most people fall under for protocol. I.E. 0-4, 5-17, 18-32. Exact entries must be looked up. varchar(10) Owned Non-key
icd9_disease_code ICD( Disease Code in which Protocol falls under. char(80) Owned Non-key
new_drug_approval Indicates whether drugs exist for protocol or not. Not inclusive of all drugs only those reported on review. char(3) Owned Non-key
new_device_approval Indicates whether investigational devices exist. Not inclusive of all devices only those reported on review. char(3) Owned Non-key
pi_last_modified_date Date modified in system. This date identifies the last date the protocol information was verified and updated. datetime Owned Non-key
pi_inactive_date Protocols are made inactive when they change institute. datetime Owned Non-key
pi_status N indicates active, y indicates inactive. char(1) Owned Non-key
principal_branch Principal Branch, Used to sort protocols char(2) Owned Non-key
principal_inst Principal Institute, Used to sort protocols char(2) Owned Non-key
accrual_inst Accrual Institute char(2) Owned Non-key
accrual_branch Accrual Branch, Used to sort protocols char(2) Owned Non-key
referral_flag Referral Letter Required For Inclussion To Protocol char(2) Owned Non-key
Normal Control Flag Indicates Normal Control Protocol char(2) Owned Non-key
irb_ceiling Ceiling of number of subjects char(2) Owned Non-key
reported_subjects_to_date Number of Subjects Reported By PI char(2) Owned Non-key




Table: cc_protocol_synonym


Description: cc_protocol_alias_info contains synonyms or aliases for protocols providing the capability to refer to a protocol using multiple names or titles.

Relationships:

1. cc_protocol_info has 0-multiple cc_protocol_alias_info.

Base NameAttribute Definition Column DatatypeAttribute Type
protocol_idProtocol ID is year and sequence number. IE, the protocol id for protocol 96-C-0023 is 960023. intOwned Key
protocol_aliasAlias or synonym for protocol. varchar(30)Owned Key
organizationOrganization that defined the alias. varchar(30)Owned Non-key
pai_last_modified_dateLast date this entry was updated in the system. datetimeOwned Non-key
date_addedDate Alias was added to system. datetimeOwned Non-key
who_addedWho Added Alias. varchar(10)Owned Non-key
who_modifiedWho Modified alias. varchar(10)Owned Non-key




Table: cc_protocol_consents


Description: cc_protocol_consents contains information relating to the consents for a given protocol. Used by the protocol consents on the web.

Relationships:

1. cc_protocol_info has 0-multiple cc_protocol_consents.
Base NameAttribute Definition Column DatatypeAttribute Type
nih_protocol_idThe protocol number assigned by the Protocol Services Section, MRD. Number is year-institute-sequence number. varchar(20)Foreign Key
arm_idID of consent used to search and find a given consent. varchar(15)Owned Key
arm_titleTitle of consent provided by MRD. varchar(80)Owned Non-key
original_filenameOriginal filename for arm provided by MRD. varchar(80)Owned Non-key
pdf_filenamePDF Filename for protocol consent. varchar(30)Owned Non-key
pc_last_modified_dateLast date this entry was updated in the system. datetimeOwned Non-key
pc_statusStatus of consent is used to determine if one or more consents of a protocol are inactive. char(1)Owned Non-key
consent_modifiedConsent Modified flag to indicate MRD changed consent and pdf of consent should have been upload. Field used for auditing for protocol consents on the web system. char(3)Owned Non-key




Table: cc_protocol_exclusions


Description: cc_protocol_exclusions contains information relating to the exclusions for a given protocol. Exclusions are currently related to ethnicity and gender.

Relationships:

1. cc_protocol_info has 0-multiple cc_protocol_exclusions.
Base NameAttribute Definition Column DatatypeAttribute Type
nih_protocol_idThe protocol number assigned by the Protocol Services Section, MRD. Number is year-institute-sequence number. varchar(20)Foreign Key
exclusion_typeExclusion indicate criteria in which are used to exclude those to participate in a protocol by either race or gender. Examples of exclusion are: Males, Females, Whites (not of hispanic origin). varchar(30)Owned Key
pe_last_modified_dateDate modified in system. This date identifies the last date the protocol information was verified and updated. datetimeOwned Non-key




Table: cc_protocol_inv_devices


Description: cc_protocol_inv_devices contains information relating to devices indicated on an protocol review. These devices relate only to those identified on a protocol review.

Relationships:

1. cc_protocol_info has 0-multiple cc_protocol_inv_devices.
Base NameAttribute Definition Column DatatypeAttribute Type
nih_protocol_idThe protocol number assigned by the Protocol Services Section, MRD. Number is year-institute-sequence number. varchar(20)Foreign Key
dev_standard_nameStandard name provided by MRD. All devices are given standard names to increase the efficiency for searching. varchar(80)Owned Key
pidev_last_modified_dateDate modified in system. This date identifies the last date the protocol information was verified and updated. datetimeOwned Non-key




Table: cc_protocol_inv_drugs


Description: cc_protocol_inv_drugs contains information relating to drugs indicated on an protocol review. These drugs relate only to those identified on a protocol review.

Relationships:

1. cc_protocol_info has 0-multiple cc_protocol_inv_drugs.
Base NameAttribute Definition Column DatatypeAttribute Type
nih_protocol_idThe protocol number assigned by the Protocol Services Section, MRD. Number is year-institute-sequence number. varchar(20)Foreign Key
drg_standard_nameStandard name provided by MRD. All drugs are given standard names to increase the efficiency for searching. varchar(80)Owned Key
pidrg_last_modified_dateDate modified in system. This date identifies the last date the protocol information was verified and updated. datetimeOwned Non-key




Table: cc_protocol_keywords


Description: cc_protocol_keywords contains the keywords of a protocol. These keywords are created through a perl program that parses out keywords from the title, precis, pi_keywords, drugs, and devices.

Relationships:

1. cc_protocol_info has 0-multiple cc_protocol_keywords.
Base NameAttribute Definition Column DatatypeAttribute Type
nih_protocol_idThe protocol number assigned by the Protocol Services Section, MRD. Number is year-institute-sequence number. varchar(20)Foreign Key
keywordKeyword extracted from precis, title, drugs, devices based on using space as a dilimiter. varchar(255)Owned Non-key
frequencyFrequency of a keyword for a given protocol. smallintOwned Non-key



Table: cc_protocol_pi_keywords


Description: cc_protocol_pi_keywords contains information relating to the keywords of a protocol. These keywords are identified by the principal investigator of a protocol. Five keywords can be entered per review with MRD keeping only the first 10 per protocol.

Relationships:

1. cc_protocol_info has 0-multiple cc_protocol_pi_keywords.
Base NameAttribute Definition Column DatatypeAttribute Type
nih_protocol_idThe protocol number assigned by the Protocol Services Section, MRD. Number is year-institute-sequence number. varchar(20)Foreign Key
keywordKeyword provided by PI. Limited to 5 per review, ten total in MRD's database. varchar(80)Owned Key
ppk_last_modified_dateDate modified in system. This date identifies the last date the protocol information was verified and updated. datetimeOwned Non-key




Table: cc_researcher_info


Description: cc_researcher_info contains internal and external researchers which include referring physicians, attending physicians, clinical associates, principal investigators and information contacts for protocols.

Relationships:

1. cc_protocol_info has a principal investigator and an information contact whose biographical data are contained in cc_researcher_info. Note: Principal Investigators and Information Contacts are entered based on fullname, institute, and branch. The result is that multiple entries may be possible for the same investigator. This will be reviewed and corrected.
Base NameAttribute Definition Column DatatypeAttribute Type
Base NameAttribute Definition Column DatatypeAttribute Type
ri_sequence_idResearcher unique identification number. numeric(9)Owned Key
ri_last_nameResearcher Last Name. varchar(30)Owned Non-key
ri_first_nameResearcher First Name. varchar(30)Owned Non-key
ri_middle_initialResearcher Middle Initial char(1)Owned Non-key
ri_suffixResearcher suffix. varchar(9)Owned Non-key
ri_prof_designationResearcher Professional Designation. varchar(9)Owned Non-key
ri_instituteResearcher Institute affiliation. char(2)Owned Non-key
ri_branchResearcher branch affiliation. char(2)Owned Non-key
ri_office_addressResearcher NIH Address for internal researchers. Street Address1 for external researchers. varchar(30)Owned Non-key
ri_office_phoneResearcher Office Phone. varchar(14)Owned Non-key
ri_office_faxResearcher Office Fax. varchar(14)Owned Non-key
ri_email_addressResearcher email address. varchar(80)Owned Non-key
ri_full_nameResearcher Full Name. varchar(60)Owned Non-key
ri_last_date_modifiedLast date this entry was updated in the system. datetimeOwned Non-key
ri_office_address_additionStreet Address 2. varchar(30)Owned Non-key
ri_office_address_cityCity varchar(30)Owned Non-key
ri_office_address_stateState varchar(30)Owned Non-key
ri_office_address_zipZip varchar(10)Owned Non-key
ri_specialitySpeciality of Researcher varchar(30) Owned Non-key
rni_nih_idNIH Research ID char(18) Owned Non-key
ri_office_address_countryCountry Address char(18) Owned Non-key




Table: cc_researcher_info


Description: cc_researcher_nih_info contains address information for principal investigators and information contacts for protocols.

Relationships:

1. cc_protocol_info has a principal investigator and an information contact whose biographical data are contained in cc_researcher_info. 1. cc_researcher_info has address information contained in cc_researcher_nih_info.
Base NameAttribute Definition Column DatatypeAttribute Type
rni_nih_idNIH Research ID char(18) Owned Non-key
rni_full_AddressNIH Full Address text Owned Non-key
rni_quick_addressNIH Research ID char(10) Owned Non-key



SCHEDULED ADDITITIONS




Table: cc_protocol_protocol_keywords_by_field


Description: cc_protocol_keywords_by_field contains information relating to the keywords of a protocol. These keywords are parsed by the perl script used to load data.

Relationships:

1. cc_protocol_info has 0-multiple cc_protocol_keywords_by_field.
Base NameAttribute Definition Column DatatypeAttribute Type
nih_protocol_idThe protocol number assigned by the Protocol Services Section, MRD. Number is year-institute-sequence number. varchar(20)Foreign Key
keywordSequence ID varchar(255)Owned Key
sequence_idKeyword numeric(9)Owned Key
field_noField Number smallintOwned Key
frequencyFrequency of word in field smallintOwned Key
last_modified_dateDate modified in system. This date identifies the last date the protocol information was verified and updated. datetimeOwned Non-key



Table: cc_protocol_fields


Description: cc_protocol_fields contains identifies the fields of a protocol in which keywords can be extracted.

Relationships:

1. cc_protocol_keywords_by_field has 1 cc_protocol_fields.
Base NameAttribute Definition Column DatatypeAttribute Type
pf_field_idField ID smallintPrimary Key
pf_descriptionName of field varchar(30)Owned Key



Table: cc_protocol_recruit_keywords


Description: cc_protocol_recruit_keywords contains information relating to the keywords of a protocol.

Relationships:

1. cc_protocol_info has 0-multiple cc_protocol_recruit_keywords.
Base NameAttribute Definition Column DatatypeAttribute Type
nih_protocol_idThe protocol number assigned by the Protocol Services Section, MRD. Number is year-institute-sequence number. varchar(20)Foreign Key
prk_keywordKeyword varchar(80)Owned Key
prk_last_modified_dateDate modified in system. This date identifies the last date the protocol information was verified and updated. datetimeOwned Non-key



Table: cc_protocol_citations


Description: cc_protocol_citations contains information relating to three citations selected by the PI.

Relationships:

1. cc_protocol_info has 0-multiple cc_protocol_citations.
Base NameAttribute Definition Column DatatypeAttribute Type
nih_protocol_idThe protocol number assigned by the Protocol Services Section, MRD. Number is year-institute-sequence number. varchar(20)Foreign Key
pcc_sequenc_idSequence ID numeric(15)Primary Key
pcc_journ_abb Journal Abbreviation varchar(80)Owned Non-key
pcc_author_last_nameAuthor Last Name varchar(80)Owned Non-key
pcc_published_yearYear Published varchar(10)Owned Non-key
pcc_article_titleArticle Title varchar(255)Owned Non-key
pcc_journal_volJournal Volume varchar(10)Owned Non-key
pcc_article_first_pageFirst Page varchar(10)Owned Non-key
pcc_last_modified_dateDate modified in system. This date identifies the last date the protocol information was verified and updated. datetimeOwned Non-key

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National Institutes of Health (NIH)
Warren Grant Magnuson Clinical Center (CC)
Information Systems Department (ISD)
Bethesda, Maryland 20892

Last modified 6/11/99