Joseph A. Frank, MD
Dr. Joseph A. Frank is chief of the Laboratory of Diagnostic Radiology Research (LDRR), Clinical Center, National Institutes of Health
(NIH), and the coordinator of the Imaging Sciences Training Program. Dr.
Frank earned his bachelor's and master's degrees in chemistry at the State
University of New York at Stony Brook. After completing an internal medicine
internship and residency at University Hospital, Boston, Massachusetts,
Dr. Frank joined NIH as a medical staff fellow with the National Cancer
Institute. In 1986, he became director of MRI research, Diagnostic Radiology
Department, Clinical Center, and in 1992 took his present position as chief
of LDRR. He is a diplomate of the National Board of Medical Examiners, and
is board-certified in internal medicine and medical oncology.
Dr. Frank is a member of the American College of Physicians;
International Society of Magnetic Resonance in Medicine; American Society
of Clinical Oncology; and the American Association for the Advancement of
Science. He serves on the editorial boards of Journal of Computer Assisted
Tomography; Society of Magnetic Resonance in Medicine; Journal
of Magnetic Resonance Imaging; Radiology; Annals of Neurology;
and Neurology.
Dr. Frank's research interests include the following:
- MRI/MRS of CNS disease: (Study of demyelination, remyelination,
neuronal/axonal damage)
- MR as an outcome measure in multiple sclerosis clinical
trials
- MR of experimental demyelination and remyelination: Imaging/pathologic
correlations
- MR microscopy
- In vivo monitoring of the natural history and effect
of new therapies in rodent disease models
- In vivo evaluation and tracking of the expansion of specifically
targeted molecular and cellular events
- Development of MR contrast agents for molecular and cellular
tags
- Real-time functional MRI
Dr. Frank has published over 160 research papers and book
chapters. A selected bibliography appears below.
SELECTED PUBLICATIONS
Frank, J.A., Ostuni, J., Yang, Y., Shiferaw, Y., Patel,
A., Qin, J., Cerebral Physiology: A Technical Solution for an Interactive
fMRI Evaluation: Application to a Physiological Interview Radiology In Press
Richert, N.D., Ostuni, J.L., Bash, C.N., Duyn, J.H., McFarland,
H.F., Frank, J.A., Serial Whole Brain Magnetization Transfer Imaging in
Relapsing-Remitting Multiple Sclerosis Patients: Natural History and the
Effect of Interferon-1b. AJNR 1998;19:1705-1713.
Xu, S., Jordan, E.K., Brocke, S., Bulte, J., Quigley, L.,
Tresser, N., Ostuni, J., Yang, Y., McFarland, H., Frank, J.A., Study of
Relapsing Remitting Experimental Allergic Encephalomyelitis SJL Mouse Model
Using MION-46L Enhanced in Vivo MRI: Early Histopathological Correlation.
Journal of Neuroscience Research 1998;52:549 558.
Xu, S. Jordan, E.K., Li, W., Yang, Y., Chesnick, S., de
Webster, H., Brocke, S., Quigley, L., McFarland, H, Frank, J.A., In Vivo
Three Dimensional MR Microscopy of Mice with Chronic Relapsing Experimental
Allergic Encephalomyelitis after treatment Insulin-like Growth Factor 1.
AJNR 1998;19:653-658
Yang, Y., Frank,, J.A., Hou, L., Ye, F., McLaughlin, A.,
Duyn, J.H., Multislice imaging of cerebral perfusion with pulsed arterial
spin-tagging, Mag. Res. Med. 1998;39:825 832.
Yang, Y, Glover, G.H., van Gelderen, P., Patel, A.C., Mattay,
V.S., Frank, J.A., Duyn, J.H. A comparison of Fast MR scan Techniques for
Cerebral Activation Studies at 1.5 Tesla. Mag Reson in Med 1998;39:61-67.
Petrella, J.R., DeCarli, C., Dagli, M., Duyn, J.H., Grandin,
C.B., Frank, J.A., Hoffman, E.A., Theodore, W.H., Age related vasodilatory
response to acetazolamide challenge in healthy adult humans: A dynamic contrast-enhanced
MR perfusion imaging study. AJNR 1998;19:39-44.
Miller, D.H., and Frank, J.A., MRI techniques to
monitor short term evolution of MS and preliminary trials. J Neurol Neurosurg,
Psychiatry 1998;64:S44-46.
Bulte,J.W.M., Brooks, R.A., Moskowitz, B.M., Bryant, L.H.,
Frank. J.A., T1 and T2 relaxometry of monocrystalline iron oxide nanoparticles
(MION-46L): theory and experiment. Acad. Radiology, 1998;5:S137-S140.
McLaughlin, A.C., Pekar, J.J., Santha, A.K.S., and Frank,
J.A., Effect of Magnetization Transfer on the Measurements of Cerebral Blood
Flow Using Arterial Spin Tagging approaches. Mag Reson Med 1997;37:501-510.
Bryant, L.H., Jr., Brechbiel, M.W., Wu, C., Bulte, J.W.M,
Herynek, V., Frank, J.A., Synthesis and Relaxometry of High Generation (G=5,
7, 9 and 10) PAMAM Dendrimer-DOTA-Gadolinium Chelates. JMRI in press.
Stone, L.A., Frank, J.A., Albert, P.S., Bash, C.N., Calabresi,
P.A., Maloni, H., and McFarland, H.F., Characterization of MRI Response
to Treatment with Interferon Beta 1b: Contrast Enhancing MRI Lesion Frequency
as a Primary Outcome Measure. Neurology 1997;49:862-869.
Frank J.A., Stone L.A., Smith, M.E., Albert, P.S., Maloni,
H., McFarland, H.F., Serial Contrast-enhanced Magnetic Resonance Imaging
in Patients with Early Relapsing Remitting Multiple Sclerosis: Implications
for Treatment Trials. Annals Of Neurology 1994;36:S86-S90.
For more information:
Email: jafrank@helix.nih.gov
Website: http://www.cc.nih.gov/ldrr
