The Georg deHevesy Nuclear Pioneer Award, Society of
Nuclear Medicine, 1997.
Dr. Eckelman has published over 200 research papers, books and book chapters. His most recent publications are listed below.
2000-01 PUBLICATIONS
KIESEWETTER DO, SASSAMAN MB, ROBBINS J, JAGODA EM, CARSON RE, NATHAN NM, SUTKOWSKI E, HERSCOVITCH P, BRAUN A, ECKELMAN WC. Synthesis and Evaluation of an F-18 Analogue of Forskolin for Imaging Adenylyl cyclase. J Fluorine Chem. 101(2), 297-304, 2000
MAGATA Y, LANG L, KIESEWETTER DO,. JAGODA EM, CHANNING MA AND ECKELMAN WC. Biologically Stable [F-18] Labeled Benzylfluoride Derivatives. Nucl Med Biol. 27: 163-168, 2000
CARACO C, ALOJ L, CHOU JY, ECKELMAN WC. Cellular [F-18]-2-fluoro-2-deoxyglucose release as a function of glucose-6-phosphatase activity. J Biol . Chem. 275: (24) 18489-18494, 2000 (10.1074/jbc.M908096199)
CARSON RE, LANG L, WATABE H, DER MG, ADAMS HR, JAGODA E, HERSCOVITCH P, ECKELMAN WC, PET evaluation of [18F]FCWAY, an analog of the 5 HT1a antagonist WAY 100635 , Nucl Med Biol, 27: (5) 493-497, 2000
LANG L, JAGODA E, SCHMALL B, SASSAMAN M, MA Y, ECKELMAN WC, Fluoro analogs of WAY 100635 with varying pharmacokinetic properties. Nucl Med Biol, 27: (5) 457-462, 2000
SHOAF SE, CARSON RE, HOMMER D, WILLIAMS WA, HIGLEY JD, SCHMALL B, HERSCOVITCH P, ECKELMAN W (1999) The suitability of [C-11]- -methyl-L-tryptophan as a tracer for serotonin synthesis: Studies with dual administration of [C-11] and [C-14] labeled tracer. J Cereb Blood Flow Metab 20: (2) 244-252, 2000
WATABE H, ENDRES CJ, BREIER A, SCHMALL B, ECKELMAN WC, CARSON RE (1999) Measurement of dopamine release with continuous infusion of [C-11]raclopride: Optimization and signal-to-noise considerations. J Nucl Med 41: (3) 522-530, 2000
WATABE H, CHANNING MA, DER MG, ADAMS HR, JAGODA E, HERSCOVITCH P, ECKELMAN WC, CARSON RE (1999) Kinetic analysis of the 5-HT2A ligand [C-11]MDL 100,907. J Cereb Blood Flow Metab 20:899-909, 2000
HSIN LW, WEBSTER EL, CHROUSOS GP, GOLD PW, ECKELMAN WC, CONTOREGGI C, RICE KC Synthesis and biological activity of fluoro-substituted pyrrolo[2,3-d]pyrimidines: The development of potential positron emission tomography imaging agents for the corticotropin-releasing hormone type 1 receptor. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 10: (8) 707-710, 2000
HSIN L-W, WEBSTER EL, CHROUSOS GP, GOLD P, ECKELMAN WC, CONTOREGGI C, RICE KC. Synthesis Of [3H](4-Fluorobutyl)propyl[2,5,6-Trimethyl-7-(2,4,6-Trimethylphenyl)Pyrrolo[2,3-D]Pyrimidin-4-yl]Amine: A Potent Radioligand For Corticotropin-Releasing Hormone Type 1 Receptor. J Labelled Cpd. Radiopharm. 43, 899-908, 2000
ECKELMAN WC, TATUM JL, KURDZIEL KA, CROFT BY. Quantitative analysis of tumor biochemistry using PET and SPECT. Nucl Med Biol.27, 633-635, 2000
BLANKENBERG FG, ECKELMAN WC, STRAUSS W, WELCH MJ, ALAVI A, ANDERSON C, BACHARACH S, BLASBERG RG, GRAHAM MM, WEBER W. Role of radionuclide imaging in trials of antiangiogenic therapy. ACADEMIC RADIOLOGY 7: (10) 851-867, 2000
M KLING, L. BORG, A ZAMETLIN, R. CARSON, J. MATOCHIK, R. MASLANSKY, E. KHURI, A. WELLS, S. LAMPERT, L. LEFTER, J. KREUTER, P. HERSCOVITCH, W. ECKELMAN, K. RICE, A. HO, AND M.J. KREEK. Opioid receptor binding in long-term methadone maintained former heroin addicts by PET [imaging] using [18F]cyclofoxy. J Pharmacol Exp Ther. 1;295(3):1070-1076, 2000
GREEN MV, SEIDEL J, VAQUERO JJ, JAGODA E, LEE I, ECKELMAN WC. High Resolution PET, SPECT, and Projection Imaging in Small Animals. Computerized Medical Imaging And Graphics to be published in a special conference issue devoted to "FRONTIERS IN NUCLEAR MEDICINE TECHNOLOGY", A Symposium Held In Mol, Belgium In May, 1999, Computed Medical Imaging and Graphics 25, 79-86, 2001
TIAN X., HSIN L-W, WEBSTER EL, CONTOREGGI C, CHROUSOS GP, GOLD P, HABIB K, AYALA A, ECKELMAN WC,JACOBSON AE, RICE KC. The Development of a Potential Single Positron Emission Computed Tomography (SPECT) Imaging Agent for the Corticotroopin-Releasing Hormone Receptor Type 1. Bioorganic & Medicinal Chem Letters 11:331-333, 2001
ZIMMERMAN BE, KUBICEK GJ, CESSNA JT, PLASCJAK PS, ECKELMAN WC. Radioassays and Experimental Evaluation of Dose Calibrator Settings for 18F. Appl Radiat Isot. 54, 113-122, 2001
CHANNING MA, HUANG BX, ECKELMAN WC. Analysis of residual solvents in 2-[F-18]FDG by GC. Nucl Med Biol. 28(4):469-71, 2001
MF SMITH, ME DAUBE-WITHERSPOON, PS PLASCJAK, LP SZAJEK, RE CARSON, JR EVERETT, SL GREEN, PR TERRITO, RS BALABAN, SL BACHARACH, WC ECKELMAN. Device-dependent activity estimation and decay correction of radionuclide mixtures with application to Tc-94m PET studies. Medical Physics 28, 36-45, 2001
MA Y, LANG L, KIESEWETTER D, JAGODA E, SASSAMAN M, DER M, ECKELMAN WC (1999). Liquid Chromatography - tandem mass spectrometry indentification of metabolites of two 5-HT1A antagonists, N-{2-[4-(2-methoxyphenyl)piperazino]ethyl}-N-(2-pyridyl) trans-and cis-4-fluorocyclohexanecarboximide, produced by human and rat hepatocytes. J of Chromatography B, 755, 47-56, 2001
ECKELMAN WC. Radiolabeled Muscarinic Radioligands for In Vivo Studies. Nucl Med Biol 28: 485-492, 2001
VERA D, ECKELMAN WC. Receptor 1980 and Receptor 2000: Twenty years of progress in Receptor-Binding Radiotracers. Nucl Med Biol.28:475-476, 2001
KIESEWETTER DO, ECKELMAN WC. Radiochemical synthesis of [18F]Fluoropaclitaxel ([18F]FPAC). J labelled Cpd Radiopharm 44:S903-S905, 2001
LEE Y-H C, KIESEWETTER DO, LANG L, JAGODA EM, SHIRANI J, DILSIZIAN V, ECKELMAN WC. Synthesis of 4-[18F]Fluorobenzoyllisinopril: a radioligand for angiotensin converting enzyme (ACE) imaging with positron emission tomography. J labelled Cpd Radiopharm 44:S268-S270, 2001
LANG L, JAGODA EM, ECKELMAN WC. The Development of Additional Radioligands of Varying Pharmacokinetics for the 5-HT1A Receptor. J labelled Cpd Radiopharm. 44:S21-S23, 2001
WAKI A, SASSAMAN MB, KAO CK, JAGODA EM, MA Y, SZAJEK LP, ECKELMAN WC. Synthesis of [76Br] 1-(2-fluoro-2-deoxy-3,5-O-Dibenzoyl-?-D-Arabinofuranosyl)-5-Bromouracil ([76Br]FBAU 3',5' Dibenzoate) and Its Evaluation as a Tracer for Imaging Brain Cell Proliferation. J labelled Cpd Radiopharm. 44:S102-103, 2001
MA Y, LANG L, KIESEWETTER DO, SASSAMAN MB , ECKELMAN WC. Metabolites of Three Phenylcarboxcyl Derivatives of the 5-HT1A Antagonists, WAY 100635, Produced by Human and Rat Hepatocytes. J labelled Cpd Radiopharm 44:S459-S461, 2001.
SZAJEK LP, DER M, PLASSCJAK P, ECKELMAN WC. Production and Radioassay of Tc-94m for PET Studies. J labelled Cpd Radiopharm 44: S764-S766, 2001
PANICO M, LANG L, SASSAMAN MB, ECKELMAN WC. Radiolabeling of Unprotected Octretide with F-18. J labelled Cpd Radiopharm 44: S922-S924, 2001
ZARET, B. L., LEPPO, J. A., BENDER, J. R., CARRIO, I., ECKELMAN, W. C., GAMBHIR, S., GREEN, A. M., NARULA, J. Molecular Imaging. Journal of Nuclear Cardiology, 8;2;256-266, 2001
ECKELMAN WC. Mechanism of Target Specific Uptake. Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J Welch & Carol Redvanly. John Wiley & Sons, Ltd, West Sussex, England. In press; 2001
JAGODA EM, KIESEWETTER DO, SHIMOJI K, GOMEZA J, WESS J, AND ECKELMAN WC. Regional Brain Uptake Of The Muscarinic Ligand, [18F]FP-TZTP, Is Decreased In M2 Knockout But Not In M4 Knockout Mice. Life Sciences LIFE SCI 68: 2634-2634, 2001
FINN R, BALATONI J, KOTHARE P, PENTLOW K, SHEH Y, LOM C, DAHL J, ECKELMAN W, PLASCJAK P, ADAMS HR, LARSON SM. Cyclotron Production and Potential Clinical application of iodine-124 Labeled Radiotracers. Applications of Accelerators in Research and Industry-sixteenth Internaltional Conference (edited by JL Duggan and IL Morgan), 849-852, 2001
For more information, email eckelman@nmdhst.cc.nih.gov
