POSTDOCTORAL POSITIONS IN THE MOLECULAR IMAGING LABORATORY AT THE NATIONAL INSTITUTES OF HEALTH
Postdoctoral positions for Ph.D. organic or medicinal chemists are available in the Molecular Imaging Laboratory at the National Institutes of Health in Bethesda, MD. The positions will involve the synthesis and characterization of new small molecule targeting agents for endothelial receptors. The research is focused on the use of these molecules for the construction of multivalent materials for new image guided therapeutics. The new Molecular Imaging Laboratory has a fully functional synthetic organic chemistry laboratory with two Ph.D. staff scientists and a principal investigator along with modern instrumentation such as UV-Vis, FT-IR, HPLC, LC-MS, GC-MS, and NMR. Previous experience with the design and the synthesis of peptidomimetics is desirable. The candidate will also be exposed to integrating genomics, proteomics, imaging sciences, and preclinical animal work into their synthetic design and execution. Please send CV to: Dr. S. Narasimhan Danthi, (ndanthi@cc.nih.gov) Molecular Imaging Laboratory, National Institutes of Health, Building 10 Room 1C660, 10 Center Dr MSC 1074, Bethesda, MD 20892.
The Imaging Sciences Program in the NIH Clinical Center seeks highly qualified Postdoctoral Fellows, Staff Fellows and Staff Scientists in the following areas:Molecular Pathology Molecular Biology Synthetic Chemistry Protein Chemistry Radiochemistry Image Processing MRI Physics Ultrasound Physics The Imaging Sciences Program offers a unique opportunity for conducting multidisciplinary research in the exciting field of in vivo molecular imaging. NIH offers an extensive benefits package that you may be eligible for, depending on the appointment mechanisms: Health Benefits, Life Insurance, Retirement Benefits, Annual and Sick Leave, Formal Training Program, Recruitment Bonus, Retention Allowance, Relocation Allowance, Loan Repayment Program, and Travel Benefits.
Candidates interested in specific job opportunities at the Imaging Science Program (ISP) should send their inquiry and C.V. to Dr. King Li, Associate Director, Radiology and ISP, e-mail: kingli@nih.gov, phone: 301-435-5741, fax: 301-496-9933.
Molecular Pathology (Staff Scientist position):
The incumbent will collaborate with other members of the team to characterize tissues at the molecular level. The incumbent must have demonstrated expertise in gross and histologic evaluation of animal tissues, and familiarity with immunohistochemical procedures, laser capture microdissection and in-situ hybridization. Experience in mammalian molecular genetics and knowledge in gene array technology is highly desirable.Molecular Biology (Staff Scientist position):
The incumbent will focus on microarray evaluation of genome expression in tissues obtained from biopsies, excision or animal experiments. Experience with general molecular biology techniques is necessary. These techniques include DNA cloning, PCR, Western/Nothern blot, etc. Additional experience in antibody phage display library, expression and purification of antibody and its fragments and antibody biological assays is highly desirable.Synthetic Chemistry (Staff Scientist position):
The incumbent will collaborate with other members of the chemistry team to develop chemical probes that can be used for imaging molecular targets in vivo. The incumbent should have primary training in synthetic chemistry. Familiarity with NMR, mass spectroscopy, IR, UV-VIS for small molecular purifications is necessary as well as methods in material characterization. Working knowledge of various imaging techniques such as MRI, CT, PET, and Nuclear Scintigraphy and experience in imaging contrast development are highly desirable. Experience in building and screening chemical libraries a plus.Protein Chemistry (Staff Scientist position):
The incumbent will collaborate with other members of the team to identify protein targets in tissues obtained from biopsies, excision or animal experiments. The incumbent is expected to drive discovery efforts by performing biochemical experiments aimed at the enrichment, high sensitivity recovery, and identification of protein targets. Critical skills include bioseparations and handling of low abundance/endogenous levels of proteins. Microbore HPLC experience is particularly desirable. Experience with mass spectroscopic analysis of in-gel digests, (photo)chemical cross-linking, and protein database searching is a strong plus.Radiochemistry (Staff Scientist position):
The incumbent will collaborate with other members of the team to develop radiolabeling techniques to trace chemical probes used in PET, SPECT, MRI, and CT. The applicant should have a doctorate in radiochemistry or a doctorate in a closely related field with extensive experience in radiochemistry. Familiarity with the tracer principle and the instrumentation to assure high chemical and radiochemical purity is a necessity.Image Processing (Staff Scientist position):
The incumbent will collaborate with other members of the team to develop quantitative models of tracer transport in small animal models and in humans using PET, SPECT, MR or CT data as input. The incumbent will also collaborate with other NIH investigators to devise, validate and implement new statistical, resolution recovery image reconstruction algorithms and methods for multi-modality image registration in small animals and in humans. The incumbent will also explore methods for automated image analysis of large volumes of multi-modality human and small animal image data. The incumbent should have a doctorate in computer science, bioengineering, biophysics or equivalent specialty and several years experience in one or more of the research areas noted above.MRI Physics (Staff Scientist position):
The incumbent will collaborate with other members of the team to manage and implement both our clinical and animal MRI/MRS research protocols. The ideal candidate should have a Ph.D. in MR Physics and research experience in using and developing innovative MR imaging and spectroscopy techniques. Excellent communication skills and the ability to work within a multidisciplinary team are required.Ultrasound Physics (Postdoctoral position):
We are developing a novel ultrasound system for imaging and also deliver high intensity focused ultrasound (HIFU) for facilitation of drug delivery and tissue ablation. The ideal candidate should have a Ph.D. in ultrasound physics with research experience in HIFU. Excellent communication skills and the ability to work within a multidisciplinary team are required.For additional job opportunities, please see the Diagnostic Radiology web site.