Biosketch
Dr. Matthew Dreher is a Staff Scientist in charge of pre-clinical operations and laboratory activities for the Interventional Radiology Research Laboratory at NIH. He earned his undergraduate degree in Biomedical Engineering from Rensselaer Polytechnic Institute and then a Masters Degree and PhD in Biomedical Engineering from Duke University. He then went on to complete a postdoctoral fellowship in the Department of Radiation Oncology in the Duke University Medical Center.
In early 2007, he came to NIH to work with Dr. Bradford Wood in the Interventional Radiology Research Laboratory that focuses on minimally invasive image guided therapies. With Dr. Dreher’s background in drug delivery and tumor microenvironment, he now focuses on novel drug and device combinations to improve local-regional therapies. His background is well suited for emerging therapies in Interventional Oncology. His specific research interests include: 1) Temperature sensitive liposomes combined with radiofrequency ablation (RFA) or high intensity focused ultrasound (HIFU), 2) RFA combined with antiangiogenic or antivascular therapy, and 3) Development of image-able drug eluting beads (DEB) for transcatheter arterial chemoembolization (TACE). Dr. Dreher’s expertise in drug delivery lets him partner with Interventional Radiology and Interventional Oncology Clinical Investigators to facilitate development and translation of novel approaches to minimally invasive, image guided therapies at the Clinical Center.
Honors and Awards
|
2007 |
Center for Biomolecular and Tissue Engineering Post-doc Achievement Award, Duke University |
|
2005 |
Center for Biomolecular and Tissue Engineering Student Achievement Award, Duke University |
|
2004 |
Graduate Student Silver Award, Material Research Society Fall Meeting |
|
2004 |
Selected Poster Award, Gordon Research Conference: Drug Carriers in Medicine and Biology |
|
2004 |
Young Investigator Travel Award, International Congress of Hyperthermic Oncology |
|
2002 |
NIH Fellow, Center for Biomolecular and Tissue Engineering, Duke University |
|
1999 |
Founders Award of Excellence, Rensselaer Polytechnic Institute |
Selected Publications
JOURNAL ARTICLES
Dreher, M.R., Sharma, K.V., Woods, D.L., Reddy, G., Tang, Y., Pritchard, W.F., Chiesa, O.A, Karanian, J.W., Esparza, J., Donahue, D., Levy, E.B., Willis, S.L., Lewis, A.L., and Wood, B.J. Radiopaque drug-eluting beads for transcatheter embolotherapy: experimental study of drug penetration and coverage in swine In Press Journal of Vascular and Interventional Radiology.
Ranjan, A., Jacobs, G., Woods, D., Negussie, A.H., Partanen, A., Yarmolenko, P.S., Gacchina, C.E., Sharma, S., Frenkel, V., Wood, B.J., and Dreher, M.R. Image-guided drug delivery with magnetic resonance guided high intensity focused ultrasound and temperature sensitive liposomes in a rabbit Vx2 tumor model. In Press Journal of Controlled Release.
Negussie, A.H., Yarmolenko, P.S., Partanen, A., Ranjan, A., Jacobs, G., Woods, D., Bryant, H., Thomasson, D., Dewhirst, M.W. Wood, B.J., and Dreher, M.R. Formulation and characterization of MR imageable thermally sensitive liposomes for use with magnetic resonance-guided high intensity focused ultrasound. International Journal of Hyperthermia, 2011;27(2):140-155.
Sharma, K.V., Dreher, M.R., Tang, Y., Pritchard, W., Chiesa, O., Karanian, J., Peregoy, J., Orandi, B., Woods, D., Donahue, D., Esparza, J., Jones, G., Willis, S.L., Lewis, A.L., and Wood, B.J. Development of “imageable” beads for transcatheter embolotherapy. Journal of Vascular and Interventional Radiology, 2010;21(6):865-876.
Negussie, A.H., Miller, J.L., Reddy, G., Drake, S., Wood, B.J., and Dreher, M.R., Synthesis and in vitro evaluation of cyclic NGR peptide targeted thermally sensitive liposome. Journal of Controlled Release, 2010;143(2):265-273.
Dreher, M.R., Fischer, K., Smith, R.J., Schmidt, M., and Chilkoti, A. Temperature triggered self-assembly of polypeptides into multivalent spherical micelles. Journal of the American Chemical Society, 2008;130(2):687-694.
Dreher, M.R. and Chilkoti, A. Toward a systems engineering approach to cancer drug delivery. Journal of the National Cancer Institute, 2007;99(13):983-985. (Editorial)
Dreher, M.R., Liu, W., Michelich, C.R., Dewhirst, M.W., and Chilkoti, A. Thermal cycling enhances accumulation of a temperature sensitive biopolymer in solid tumors. Cancer Research, 2007;67(9):4418-4424.
Dreher, M.R., Liu, W., Michelich, C.R., Dewhirst, M.W., Yuan, F., and Chilkoti, A. Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. Journal of the National Cancer Institute, 2006;98(5):335-343.
Moeller, B.J., Dreher, M.R., Rabbani, Z.N., Schroeder, T., Cao, Y., and Dewhirst, M.W. Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Cancer Cell, 2005;8(2):99-110.
Dreher, M.R., Raucher, D., Balu, N., Colvin, O.M., Ludeman, S., and Chilkoti, A. Evaluation of an elastin-like polypeptide and doxorubicin conjugate for cancer therapy. Journal of Controlled Release, 2003;91(1-2):31-43.
