Biosketch
Dr. Panyutin earned her Doctoral degree in Epidemiology from Moscow State Medical Academy in 1980 and worked as an Epidemiologist at a Disease Control Station in Moscow, Russia. After coming to USA she worked as a research scientist at Braton Biotech Inc., Rockville, Maryland from 1992 to 1996. Her work included Flow cytometry and immuno-histochemical analysis of HIV patients' samples, quality control and quality assurance procedures for clinical laboratory.
Since 1996 she has been at the NIH, Nuclear Medicine Department. Her main responsibilities include management of operations of the Nuclear Medicine research laboratory including quality control and quality assurance procedures for cell culture, biochemistry, flow cytometry, and fluorescent microscopy.
Dr. Panyutin's research interests include sequence-specific gene inactivation by triplex-directed radioactive isotopes; intracellular transport of radiopharmaceuticals; analysis of the mechanism of gamma-radiation induced micronuclei formation; study the effect of 60Co gamma-radiation and uptake of 5-[125I]iodo-2'-deoxyurinine (125IdU) on human embryonic stem cells survival, proliferation and differentiation.
Selected Publications
1. "Dynamics of the transcriptome response of cultured human embryonic stem cells to ionizing radiation exposure." Mutation research 2011;709-710():40-8. Mykyta V Sokolov; Irina V Panyutin; Igor G Panyutin; Ronald D Neumann.
2. "Expression of pluripotency-associated genes in the surviving fraction of cultured human embryonic stem cells is not significantly affected by ionizing radiation." Gene 455:8 (2010). Mykyta V Sokolov, Irina V Panyutin, Mykola I Onyshchenko, Igor G Panyutin and Ronald D Neumann.
3. "Intracellular traffic of oligonucleotides in and out of the nucleus:effect of exportins and DNA structure." Oligonucleotides 20(6):277-84 (2010). Stephen Forsha, Irina V Panyutin, Ronald D Neumann and Igor G Panyutin.
4. "Phosphorylation of histone H2AX in radiation-induced micronuclei." Radiat Res. 2007 Oct; 168 (4):493-8. Natalia G. Medvedeva, Irina Panyutin, Igor G. Panyutin and Ronald D. Neumann.
5. "Targeting linear duplex DNA with mixed-base peptide nucleic acid oligomers facilitaded by bisPNA openers." Anal Biochem. 2007 Mar 1:362(1) - 145-7. Panyutin IG, Panyutin IV, Demidov VV.
6. "DNA damage produced by 125I - triplex-forming oligonucleotides as a measure of their successful delivery into cell nuclei." Ann NY Acad Sci. 2005 Nov: 1058, 140-50. Panyutin IV, Sedelnikova OA, Bonner WM, Panyutin IG, Neumann RD.
7. "Assessment of DNA damage produced by 125I-triplex-forming oligonucleotides in cells." Int J Radiat Biol. 2004: 80 (11-12) 927-31. Sedelnikova OA, Panyutin IV, Neumann RD, Bonner WM, Panyutin IG.
8. "Repair of sequence -specific 125I -induced double strand breaks by non-homologous DNA end joining in mammalian cell-free extracts." J Biol Chem. 2002 Apr 5: 277 (14) 11756-64. Odersky A, Panyutin IV, Luu AN, Panyutin IG, Schunck C, Feldmann E, Goedecke W, Neumann RD, Obe G, Pfeiffer P.
9. "Strand breaks in whole plasmid DNA produced by decay of 125I in a triplex-forming oligonucleotides." Radiat Res. 2001 Aug; 1 156 (2): 158-66.Panyutin IV, Luu AN, Panyutin IG, Neumann RD.
