Biosketch
Dr. Panyutin earned his MS degree in molecular biophysics from the Moscow Institute of Physics and Technology and PhD degree from the Lomonosov Moscow State University (Russia), and continued his research on conformational transitions in DNA in the Engelhardt Institute of Molecular Biology and then in the Zelinsky Institute of Organic Chemistry (Moscow, Russia). Since 1991, he has been at the NIH, first at NIDDK and then, since 1993, at the NIH Clinical Center, where he has been developing DNA-based radiopharmaceuticals for gene-targeted radiotherapy.
Dr. Panyutin’s research interests include study of structural dynamics and sequence-specific targeting of DNA; gene targeting and gene expression regulation by sequence-specific molecules, such as triplex-forming oligonucleotides, peptide nucleic acids, and their analogs; delivery of DNA- and RNA-targeting probes into cell nuclei and their intracellular transport; utilization of Auger electron emitting radionuclides delivered by DNA sequence specific probes for gene inactivation; anti-gene radiotherapy; higher order DNA structures and DNA-protein interactions; structure, dynamics, and genetic functions of nucleic acids; gene regulation; DNA repair, molecular mechanisms of recombination and transcription; multistranded DNA complexes (triplexes, telomeric DNA structure, Holliday junctions); effects of physical energy deposition (ionizing radiation, UV-lasers) on DNA structure and function; radiobiology of Auger-electron emitting radioisotopes; gene/protein expression profiles, and bystander effects.
Selected Publications
I.G.Panyutin, V.I.Lyamichev, Yu.L.Lyubchenko. (1982). A sharp structural transition in pAO3 plasmid DNA caused by increased superhelix density. FEBS Lett. 148, 297-301.
I.G.Panyutin, O.I.Kovalsky, E.I.Budowsky, R.E.Dickerson, M.E.Rikhirev, A.A.Lipanov. (1990). G-DNA: A twice-folded DNA structure adopted by single-stranded oligo(dG) and its implication for telomeres. Proc. Natl. Acad. Sci. USA 87, 867-870.
I.G.Panyutin and P. Hsieh. (1994). The Kinetics of Spontaneous DNA Branch Migration. Proc. Natl. Acad. Sci. USA 91, 2021-2025.
I.G.Panyutin and R.D.Neumann. (1994) Sequence-specific DNA double strand breaks induced by triplex forming 125I labeled oligonucleotides. Nucleic Acids Res., 22, 4979-4982.
I.G.Panyutin, I. Biswas and P. Hsieh. (1995) A Pivotal Role for the Structure of the Holliday Junction in DNA Branch Migration. The EMBO Journal, 14, 1819-1826.
V.N. Karamychev, V. B. Zhurkin, S. Garges, R.D.Neumann and I.G.Panyutin, (1999) Detecting the DNA kinks in a DNA-CRP complex in solution with Iodine-125 radioprobing. Nature Srtuct. Biol. 6, 747-750
Mykyta V. Sokolov, Lubomir B. Smilenov, Eric J. Hall, Igor G. Panyutin, William M. Bonner, Olga A. Sedelnikova. Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts. Oncogene 24, 7257–7265 (2005)
Igor G. Panyutin and Ronald D. Neumann. The potential for gene-targeted radiation therapy of cancers. Trends in Biotechology, 23, 492-496 (2005)
M. V. Sokolov, N. A. Smirnova, R. D. Camerini-Otero, R. D. Neumann and I. G. Panyutin, Microarray analysis of differentially expressed genes after exposure of normal human fibroblasts to ionizing radiation from an external source and from DNA-incorporated iodine-125 radionuclide. Gene 382, 47-56 (2006).
Gaynutdinov TI, Neumann RD, Panyutin IG. Structural polymorphism of intramolecular quadruplex of human telomeric DNA: effect of cations, quadruplex-binding drugs and flanking sequences. Nucleic Acids Res. 36, 4079-87 (2008)
