T1 correction for physiological and scan parameter variations in gadolinium enhanced myocardium. Despite careful control of MRI parameters, comparison of T1 times between different patients may be problematic because of patient specific factors such as gadolinium dose, differing glomerular filtration rates and patient specific delay times. The correction is based on a model driven approach to account for variations between patients in order to allow for comparison of T1 data. Kinetic model parameter values were derived from healthy volunteer time-contrast curves. Correction values for the factors described above are used to normalize T1 values to a matched state.
For further information, contact Dr. Neville Gai, 301-402-5114,gaind@cc.nih.gov
