Zhigang Li is the Research Specialist.
Work Contact Information
Brigham and Women's Hospital
Thorn 530
75 Francis Street
Boston, MA 02115
Ph: 617-732-6627
Fax: 617-278-6921
Place of Birth
Shanghai, China
Education
Graduate of East China Institute of Chemical Technology
Employment
- 1982-86 Research Assistant, Shanghai Institute of Plant Physiology, Academica Sinica, Shanghai, China
- 1986-93 Research Associate, Boston Biomedical Research Institute, Boston, MA
- 1933-95 Research Fellow, Deaconess Hospital, Harvard Medical School, Boston, MA
- 1995-2000 Research Associate, Brigham and Women’s Hospital, Boston, MA
- 2000- Research Specialist, Brigham and Women’s Hospital, Boston, MA
Publications
- Zhang Y, Cao Q, Li Z, Cui D. Preparation of [B23-D-alanine]des-(B25-B30)-hexapeptide-insulin by a combination of enzymic and non-enzymic synthesis. Biochem J 1983; 215:697-699.
- Zhu J, Li Z, Wang L, Shen S. Temperature sensitivity of a nif A-like gene in Enterobacter cloacae. J Bacteriology 1986; 357-359.
- Jiang S, Yu G, Li Z, Hong J. Genetic evidence for modulation of the activator by two regulatory proteins involved in the exogenous induction of phosphoglycerate transport in salmonella typhimurium. J Bacteriology 1988; 4304-4308.
- Sacks DB, Lopez MM, Li Z, Kosk-Kosicka D. Analysis of phosphorylation and mutation of tyrosine residues of calmodulin on its activation of the erythrocyte Ca2+-transporting ATPase. Eur J Biochem 1996; 239:98-104.
- Ho YD, Joyal JL, Li Z, Sacks DB. IQGAP1 integrates Ca2+/calmodulin and Cdc42 signaling. J Biol Chem 1999; 274:464-470.
- Li Z, Kim SH, Higgins JM, Brenner MB, Sacks DB. IQGAP1 and calmodulin modulate E-cadherin function. J Biol Chem 1999; 274:37885-37892.
- Li Z, Joyal JL, Sacks DB. Binding of IRS proteins to calmodulin is enhanced in insulin resistance. Biochemistry 2000; 39:5089-5096.
- Kim SH, Li Z, Sacks DB. E-cadherin-mediated cell-cell attachment activates Cdc42. J Biol Chem 2000; 275:36999-37005.
- Li Z, Joyal JL, Sacks DB. Calmodulin enhances the stability of the estrogen receptor. J Biol Chem 2001; 276: 17354-17360.
- Sokol SY, Li Z, Sacks DB. The effect of IQGAP1 on Xenopus embryonic ectoderm requires Cdc42. J Biol Chem 2001; 276:48425-48430.
- Briggs MW, Li Z, Sacks DB. IQGAP1-mediated stimulation of transcriptional co-activation by b-catenin is modulated by calmodulin. J Biol Chem 2002; 277:7453-7465.
- Swart-Mataraza JM, Li Z, Sacks DB. IQGAP1 is a component of Cdc42 signalling to the cytoskeleton. J Biol Chem 2002; 277:24753-24763.
- Mataraza JM, Briggs MW, Li Z, Frank R, Sacks DB. Identification and characterization of the Cdc42-binding site of IQGAP1. Biochem Biophys Res Commun 2003; 305:315-321.
- Li L, Li Z, Sacks DB. Calmodulin regulates the transcriptional activity of estrogen receptors: selective inhibition of calmodulin function in subcellular compartments. J Biol Chem 2003; 278:1195-1200.
- Li Z, Sacks DB. Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1. J Biol Chem 2003; 278:4347-4352.
- Mataraza JM, Briggs MW, Li Z, Entwistle A, Ridley AJ, Sacks DB. IQGAP1 promotes cell motility and invasion. J Biol Chem 2003; 278:41237-45.
- Roy M, Li Z, Sacks DB. IQGAP1 binds ERK2 and modulates its activity. J Biol Chem 2004; 279:17329-37.
- Li Z, McNulty DE, Marler KJM, Lim L, Hall C, Annan RS, Sacks DB. IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner. J Biol Chem 2005; 280:13871-8.
- Li L, Li Z, Sacks DB. The transcriptional activity of estrogen receptor-alpha is dependent on Ca2+/calmodulin. J Biol Chem 2005; 280:13097-104.
- Ren JG, Li Z, Crimmins DL, Sacks DB. Self-association of IQGAP1: Characterization and functional sequelae. J Biol Chem 2005; 280:34548-34557.
- Roy M, Li Z, Sacks DB. IQGAP1 is a scaffold for mitogen-activated protein kinase signalling. Mol Cell Biol 2005; 25:7940-52.
- Li L, Li Z, Howley PM, Sacks DB. E6AP and calmodulin reciprocally regulate estrogen receptor stability. J Biol Chem 2006; 281:1978-85.
- Mataraza JM, Li Z, Jeong HW, Brown MD, Sacks DB. Multiple proteins mediate IQGAP1-stimulated cell migration. Cell Signal 2007; 19:1857-65.
- Ren JG, Li Z, Sacks DB. IQGAP1 modulates activation of B-Raf. Proc Natl Acad Sci USA 2007; 104:10465-9.
- Jeong HW, Li Z, Brown MD, Sacks DB. IQGAP1 binds Rap1 and modulates its activity. J Biol Chem 2007; 282:20752-62.
- Brown MD, Bry L, Li Z, Sacks DB. IQGAP1 regulates Salmonella invasion through interactions with actin, Rac1 and Cdc42. J Biol Chem 2007; 282:30265-72.
- Jadeski L, Mataraza JM, Jeong HW, Li Z, Sacks DB. IQGAP1 stimulates proliferation and enhances tumourigenesis of human breast epithelial cells. J Biol Chem 2008; 283:1008-17.
- Owen D, Campbell LJ, Littlefield K, Evetts KA, Li Z, Sacks DB, Lowe PN, Mott HR. The IQGAP1-Rac1 and IQGAP1-Cdc42 Interactions: INTERFACES DIFFER BETWEEN THE COMPLEXES. J Biol Chem 2008; 283:1692-704.
- Ren JG, Li Z, Sacks DB. IQGAP1 integrates Ca2+/calmodulin and B-RAF signaling. J Biol Chem 2008; 283:22972-82.
- Brown MD, Bry L, Li Z, Sacks DB. Actin pedestal formation by EPEC is regulated by IQGAP1, calcium and calmodulin. J Biol Chem 2008; 283:35212-22. PMCID: PMC2596374
- McLaughlin LM, Govoni G, Gerke C, Gopinath S, Peng K, Laidlaw G, Chien Y-H, Jeong H-W, Li Z, Brown MD, Sacks DB, Monack DT. The Salmonella effector SseI mediates long-term systemic systemic infection by modulating host cell migration. PLoS Pathog 2009; 5 (11):e1000671. PMCID: PMC2777311