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Colin D. White, PhD Curriculum Vitae

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Work Contact Information

Phone: 617-735-2508
Fax: 617-735-2480
Email: cdwhite@bidmc.harvard.edu

Place of Birth

Belfast, United Kingdom

Education

2005	BSc (Hons)	Physiology	University of Aberdeen, Aberdeen, United Kingdom
2009	PhD	Molecular Oncology	University of Edinburgh, Edinburgh, United Kingdom

Postdoctoral Training

2008-2010	Postdoctoral Fellow	Pathology (David Sacks)	Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
2011-	Postdoctoral Fellow	Pathology (David Sacks/Alex Toker)	Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts

Postdoctoral Training

2005-2008	Member, Institute of Biology
2005-2008	Member, Biochemical Society
2005-2008	Member, Endocrine Society
2009-	Member, American Society of Investigative Pathology
2010-	Member, American Association for Cancer Research
2011-	Member, Faculty of 1000

Editorial Activities

Ad hoc Reviewer

Biochemical Journal
Cell and Tissue Research
International Journal of Cancer
Journal of the Royal Society Interface
Neuroendocrinology

Report of Funded Projects

Current:

2009-2012: PI - Department of Defense, Breast Cancer Research Program - $241,893
The Role of IQGAP1 in Breast Carcinoma
The major goal of this project is to identify and characterize the molecular mechanism(s) by which IQGAP1 stimulates breast tumorigenesis and metastasis.

Report of Local Teaching and Training

Laboratory and Other Research Supervisory and Training Responsibilities

2010: Hina Emmanuel - Supervisor - 240 hours/year
2010: Hina Zulfqar - Supervisor - 240 hours/year

Local Invited Presentations

2009: IQGAPs in Tumorigenesis - Invited Speaker
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts - Sponsor: None

Report of Regional, National and International Invited Teaching and Presentations

Regional Invited Presentations and Courses

2006: ERK Activation by the Gonadotropin-Releasing Hormone Receptor is Mediated via the Gαq Signaling Pathway - Invited Speaker
Bioscience 2006, Glasgow, United Kingdom - Sponsor: None

2010: IQGAPs: Oncogenes and Tumor Suppressors? - Invited Speaker
Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts - Sponsor: None

National Invited Presentations and Courses

2010: IQGAP1 is a Novel HER2 Binding Partner and Regulates HER2-Mediated Cell Proliferation - Invited Speaker
Experimental Biology 2010, Anaheim, California - Sponsor: None

Report of Scholarship

Peer Reviewed Publications in print or other media

Research Investigations

1. Lu ZL, Coetsee M, White CD, Millar RP. Structural determinants for ligand-receptor conformational selection in a peptide G protein-coupled receptor. J Biol Chem 2007; 282:17921-17929.
2. White CD, Coetsee M, Morgan K, Flanagan CA, Millar RP, Lu ZL. A crucial role for Gα_q/11, but not Gα_i/o or Gα_s in gonadotropin-releasing hormone receptor-mediated cell growth inhibition. Mol Endocrinol 2008; 22:2520-2530.
3. White CD, Khurana H, Gnatenko DV, Li Z, Odze RD, Sacks DB, Schmidt VA. IQGAP1 and IQGAP2 are reciprocally altered in hepatocellular carcinoma. BMC Gastroenterol 2010; 10:125.
4. White CD, Li Z, Sacks DB. Calmodulin binds HER2 and modulates HER2 signaling. Biochim Biophys Acta 2010; in press.
5. McNulty DE, Li Z, White CD, Sacks DB, Annan RS. MAP kinase scaffold IQGAP1 binds the EGF receptor and modulates its activation. J Biol Chem 2011; in press.

Non-peer reviewed scientific or medical publications/materials in print or other media

Reviews, chapters, monographs and editorials

1. White CD, Stewart AJ, Lu ZL, Millar RP, Morgan K. Antiproliferative effects of GnRH agonists: Prospects and problems for cancer therapy [Review]. Neuroendocrinology 2008; 88: 67-79.
2. White CD, Brown MD, Sacks DB. IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis [Review]. FEBS Lett 2009; 583:1817-1824.
3. White CD, Sacks DB. Regulation of MAP kinase signaling by calcium. Methods Mol Biol 2010; 66:151-165.
4. Kim H, White CD, Sacks DB. IQGAP1 in microbial pathogenesis: targeting the actin cytoskeleton [Review]. FEBS Lett 2011; 585:723-729.
   

Abstracts, Poster Presentations and Exhibits Presented at Professional Meetings

Abstracts

1. White CD, McArdle K, Hawksworth GM. Hepatotoxicity of canabinoids in vitro. Toxicology 2006; 219:241.
2. White CD, Gallagher R, Morgan K, Millar RP, Lu ZL. ERK activation by the gonadotropin-releasing hormone receptor is mediated via the Gαq-signaling pathway. Bioscience 2006, Glasgow, United Kingdom. 2006.
3. White CD, Morgan K, Millar RP, Lu ZL. Activation of the MAPK cascades by GnRH: A crucial role for the mammalian GnRH receptor coupling to Gq/11. Life Sciences 2007, Glasgow, United Kingdom. 2007.
4. Lu ZL, Stewart A, White CD, Millar RP. Molecular Mechanisms of the GnRH receptor activation. Endo 2007, Toronto, Canada. 2007.
5. White CD, Morgan K, Millar RP, Lu ZL. MAPK activation by the gonadotropin-releasing hormone receptor is mediated via the Gαq-signaling pathway. Endo 2007, Toronto, Canada. 2007.
6. Khurana H, White CD, Sacks DB, Schmidt VA, Odze RD. IQ motif-containing GTPase-activating proteins (IQGAPs) are an extremely sensitive and specific biomarker of hepatocellular carcinoma. Mod Pathol 2010; 23:151A.
7. White CD, Li Z, Niepel M, Sacks DB. IQGAP1 is a novel HER2 binding partner and regulates HER2-mediated cell proliferation. FASEB J 2010; 24: 421.10.
8. White CD, Gnatenko DV, LaComb JF, Sacks DB, Schmidt VA. GTPase-activating protein IQGAP2 is a novel tumor suppressor in hepatocellular carcinoma. American Association for Cancer Research 101st Annual Meeting, Washington, District of Colombia. 2010.