Teams

Project

Investigators

NCI
NIAID
Ludwig Institute for Cancer Research
Weill Med College Cornell

"Targeting cancer-testis gene expression for lung cancer therapy"

PIs: D. Schrump, MD, NCI; V. Lobanenkov, PhD, NIAID; L. Old, MD, Ludwig Institute for Cancer Research and N. Altorki, MD, Weill Med College, Cornell
AIs: M. Rao, PhD, NCI; J. Hong, MS, NCI; D. Loukinov, PhD, NIAID

NINR
U of MD

"Molecular mechanisms of glial cell modulation of chemotherapy-induced painful peripheral neuropathy"

PIs: X. Wang, MD, PhD, NINR; S. Dorsey, RN, PhD, U of MD; C. Renn, RN, PhD, U of MD
AIs: A. Mannes, MD, CC; L. Saligan, RN, PhD, NINR

Teams

Project

Investigators

NCI
UCSD

"New strategies to decrease and eradicate HIV-1 reservoirs"

PIs: F. Maldarelli, MD, PhD, NCI: E. Reid, MD, UCSD
AIs: E. Freed, PhD, NCI; S. Palmer, PhD, NCI; V. Pathak, PhD, NCI

NICHD
Case

"HIV-1 suppression by Acyclovir in patients coinfected with human herpesviruses from basic mechanism to clinical application"

PIs: L. Margolis, PhD, NICHD; M. Lederman, MD, Case Western
AIs: E. Freed, PhD, NCI; S. Palmer, PhD, NCI; V. Pathak, PhD, NCI

NIAID
CNMC
NCI

"Non-invasive cardiac 3T MRI for evaluation of premature coronary artery disease and myocardial dysfunction in adolescents and young adults with HIV acquired in infancy and childhood"

PIs: C. Hadigan, MD, MPH, NIAID; A. Gharib, MD, NHLBI; R. Cross, MD, MS, CNMC; S. Clauss, MD, CNMC
AIs: R. Hazra, MD, NICHD; J. Purdy, MSN, CRNP, NCI

Teams

Project

Investigators

NIAID
JHU
Uganda (Makere Medical School, Mulago Hospital)

"Hepatitis B and HIV co-infection in Uganda"

PIs: T. Quinn, MD, NIAID, L. Stabinski, MD, MPH, NIAID and C. Thio, MD, JHU and G. Kirk, MD, MPH, PhD, JHU; AI from NIAID: S. Reynolds, MD;
AIs from JHU: R. Gray, MBBS, MSc and D. Thomas, MD, MPH; AIs from Uganda: P. Ocama, MD and D. Serwadda, MD, Msc, MPH

NCI
FDA
U of WA

"Development and evaluation of a nanoparticle-based HIV-1 p24 antigen assay for monitoring therapy in resource limited settings"

PIs: F. Maldarelli, MD, PhD, NCI: Dr. I. Hewlett, FDA; L. Frenkel, MD, U of WA

Teams

Project

Investigators

NIDDK
U of Michigan

"Towards molecular marker based management of diabetic nephropathy in Pima Indians"

PIs: R. Nelson, MD, PhD, NIDDK; M. Kretzler, MD, U MI
AIs: E. J. Weil, MD, NIDDK; W. Knowler, MD, DrPH, NIDDK' S. Pennathur, MBBS, UMI; P. Woolf, PhD, UMI

Teams

Project

Investigators

NHGRI
Univ of SC
Univ of TX-MD Anderson

"Predicting the response to treatment using gene mutation profiling in metastatic melanoma patients"

PIs: Y. Samuels, PhD, NHGRI; P. Buckhaults, PhD, U of SC; and P. Hwu, MD, U of TX MD Anderson

NHLBI

"Graft-Versus-Host Disease: novel cellular therapy using selective thawing of umbilical cord blood to obtain an aliquot for ex-vivo natural killer cell expansion and infusion following allogeneic hematopoietic stem cell transplantation"

PIs: R. Childs, MD, NHLBI; S. Vasu, MD, DTM CC
AIs: M. Berh; A. Lundqvist, NHLBI

CC/CCMD
NHLBI
INOVA Fairfax Hosp

"Evaluation of the platelet transcriptome expression profile in pulmonary arterial hypertension"

PIs: R.F. Machado, MD, NHLBI (Clinical /Translational); N. Raghavachari, PhD, NHLBI  (Basic Science); S. Nathan, MD, INOVA
AIs: M.J. Cuttica, MD, CC/CCMD, M.T. Gladwin, MD, NHLB

NHLBI
Harvard
Temple Univ
CC

"Characterization of Jak/Stat activation in patients with monosomy 7 and the development of targeted therapy for patients using a Jak2 inhibitor"

PI: A. Freeman, MD, S. Holland, MD, NIAID
PI: E. Mitre, MD, USUHS
AIs: from NCI, NHGRI, NIAID, CC, USUHS and UCSF

NHLBI
Imperial College, London

"Development of immunotherapeutic strategies to overcome tolerance in leukemia"

PIs: A. John Barrett, MD, NHLBI; K. Rezvani, MD, PhD, Imperial College School of Med
AIs: J. Apperley, MD, London; D. Altman, MD, London; A. Yong, MD, PhD, NHLBI; Q. Le, MD, PhD, NHLBI

NIAID
NCI

"Recombinant human IL-& (CYT107) as immunomodulatory therapy for idiopathic CD4 lymphopenia: a phase I/IIA open-label pilot study"

PIs: J. Brenchley, PhD, NIAID; I. Sereti, MD, MHS, NIAID
AIs: J. Estes, PhD, NCI; B. Porter, MD, NIAID; P. Mannon, MD, NIAID; J. Hodge, BS, NIAID

Teams

Project

Investigators

NHLBI
NCI

"Immunogenicity of quadrivalent human papilloma virus vaccine (HPV Types 6, 11, 16, 18) in recipients of reduced intensity hematologic stem cell transplantation (HSCT)"

PIs Bedside: A. Chenoy, MD, NHLBI and P. Stratton, MD, NICHD
PIs Bench:  L. Pinto, MD, NCI and L. Wood, MD, NCI

NICHD
NIDDK
Sackler School of Med, Tel Aviv, Israel

"Histaminergic pathways and energy intake in obese women"

PIs: J. Yanovski, MD, PhD, NICHD; L. Yanoff, MD, NICHD; C. Cropp, PharmD, NICHD
AIs: K. Chen, PhD, NIDDK; K. Calis, PharmD, CC; D. Savastano, PhD, NICHD; N. Barak, MD, Sackler School of Med, Tel Aviv