The Bench-to-Bedside (B2B) Program funds research teams seeking to translate basic scientific findings into therapeutic interventions for patients and to increase understanding of important disease processes.
The B2B Program accomplishes this mission by addressing barriers, such as the traditional silos between basic and clinical researchers in biomedical research, which can hinder progress toward finding new therapeutics for patients in need. B2B teams involve basic and clinical researchers, often from different NIH Institutes and Centers. In 2006, the B2B program's charge was expanded to unite the efforts of intramural and extramural NIH researchers. Intramural science refers to research that takes place on an NIH campus under the auspices of federal employees, while extramural research is funded by NIH and conducted by investigators and institutions outside of NIH.
The B2B program exemplifies the benefits associated with intramural – extramural collaborations; the extramural community gains access to the Clinical Center's unique resources, and the intramural community can pursue innovative research with extramural investigators.
A B2B award provides up to $135,000 a year for two years. Projects, which are funded by various NIH offices and institutes*, have represented several research categories: AIDS, rare diseases, behavioral and social sciences, minority health and health disparities, women's health, rare diseases drug development, pharmacogenomics, and general.
Through the end of the 2013 program cycle, about 700 principal and associate investigators have collaborated on 219 funded projects with approximately $50M distributed in total bench-to-bedside funding. The introduction of extramural collaborations in 2006 has resulted in partnerships at 79 institutions, 30 of which are Clinical and Translational Science Award sites.
The B2B program will accept letters of intent for its next cycle of awards in spring 2014. Please check this website for the call for proposals in April 2014.
Text version of the slideshow
- Slide One: Bench-to-Bedside logo
- Slide Two: Dr. Frank Maldarelli discusses his project, "New Bioinformatic Approach to Determine HIV Incidence"
- Slide Three: Dr. Manfred Boehm discusses his project, "Aneurysm Formation in Patients with Mutation of STAT3"
- Slide Four: Dr. Jack Yanovski discusses his project, "FTO and Eating in the Absence of Hunger"
- Slide Five: Dr. Joan Hoan discusses her project, "WAGR Syndrome: Clinical Characterization and Correlation with Genotype"
- Slide Six: Dr. Michael Iadarola's discusses his project, "New Treatments for Intractable Pain"
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